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| 1 | Incidence and characteristics of HBV reactivation in hematological malignant patients in south Egypt显示文摘AIM:To investigate characteristics of hepatitis B virus(HBV)implicated in HBV reactivation in patients with hematological malignancies receiving immunosuppressive therapy.METHODS:Serum samples were collected from 53 patients with hematological malignancies negative for hepatitis B surface antigen(HBsAg)before the start of and throughout the chemotherapy course.HBV reactivation was diagnosed when the HBsAg status changed from negative to positive after the initiation of chemotherapy and/or when HBV DNA was detected by realtime detection polymerase chain reaction(RTD-PCR).For detecting the serological markers of HBV infection,HBsAg as well as antibodies to the core antigen(antiHBc)and to the surface antigen were measured in the sera by CEIA.Nucleic acids were extracted from sera,and HBV DNA sequences spanning the S gene were amplified by RTD-PCR.The extracted DNA was further subjected to PCR to amplify the complete genome as well as the specific genomic sequences bearing the enhancerⅡ/core promoter/pre-core/core regions(nt1628-2364).Amplicons were sequenced directly.RESULTS:Thirty-five(66%)of the 53 HBsAg-negative patients were found to be negative serologically for antiHBc,and the remaining 18(34%)patients were positive for anti-HBc.Five of the 53(9.4%)patients with hematologic malignancies experienced HBV reactivation.Genotype D1 was detected in all five patients.Four types of mutant strains were detected in the S gene product of HBV strains and were isolated from 3 patients with HBV reactivation:T/S120,L143,and I126.HBV DNA was detected in the pretreatment HBsAg-negative samples in one of the five patients with HBV reactivation.In this patient,sequences encompassing the HBV full genome obtained from sera before the start of chemotherapy and at the time of de novo HBV hepatitis were detected and it showed 100%homology.Furthermore,in the phylogenetic tree,the sequences were clustered together,thereby indicating that this patient developed reactivation from an occult HBV infection.CONCLUSION:Past infection with HBV is a risk factor for HBV reactivation in Egypt.Mandatory anti-HBc screening prior to chemotherapy in patients with hematological malignancies is recommended. | Abeer Elkady Sahar Aboulfotuh Elsayed Mostafa Ali Douaa Sayed Nashwa M Abdel-Aziz Amany M Ali Shuko Murakami Sayuki Iijima Yasuhito Tanaka | 2013 | World Journal of Gastroenterology2013，19，37： | 7 |
| 2 | Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt显示文摘AIM To investigate the prevalence and virological characteristics of occult hepatitis B virus(HBV) infections in patients with hematological malignancies in South Egypt.METHODS Serum samples were collected from 165 patients with hematological malignancies to monitor titers of HBV DNA, hepatitis B surface antigen(HBs Ag), and antibodies to HBV core(anti-HBc) and surface antigens. Serum samples negative for HBs Ag and positive for anti-HBc were subjected to nucleic acid extraction and HBV DNA detection by real-time polymerase chain reaction. DNA sequences spanning the S region were analyzed in cases with occult HBV infection. In vitro comparative study of constructed 1.24-fold wild type and S protein mutant HBV genotype D clones was further performed. RESULTS HBV DNA was detected in 23(42.6%) of 54 patients with hematological malignancies who were HBsA g negative, but anti-HBc positive, suggesting the presence of occult HBV infection. The complete HBV genome was retrieved from 6 occult HBV patients, and P120 T and S143 L were detected in 3 and 2 cases, respectively. Site directed mutagenesis was done to produce 1.24-fold genotype D clones with amino acid mutations T120 and L143. The in vitro analyses revealed that a lower level of extracellular HBsA g was detected by chemiluminescence enzyme immunoassay(CLEIA) with the clone containing T120 mutation, compared with the wild type or the clone with S143 L mutation despite the similar levels of extracellular and intracellular HBs Ag detected by Western blot. Southern blot experiments showed that the levels of intracellular HBV DNA were not different between these clones. CONCLUSION Occult HBV infection is common in patients with hematological malignancies and associated with P120 T and S143 L mutations. 120 T mutation impairs the detection of HBsA g by CLEIA. | Abeer Elkady Sayuki Iijima Sahar Aboulfotuh Elsayed Mostafa Ali Douaa Sayed Nashwa M Abdel-Aziz Amany M Ali Shuko Murakami Masanori Isogawa Yasuhito Tanaka | 2017 | World Journal of Hepatology2017，9，9： | 2 |
| 3 | Hepatic and gastrointestinal disturbances in Egyptian patients infected with coronavirus disease 2019: A multicentre cohort study显示文摘BACKGROUND Various liver and gastrointestinal involvements occur in patients with coronavirus disease 2019(COVID-19)at variable prevalence.Most studies report mild liver function disturbances correlated with COVID-19 severity,though liver failure is unusual.AIM To study liver and gastrointestinal dysfunctions in Egyptian patients with COVID-19 and their relation to disease outcomes METHODS This multicentre cohort study was conducted on 547 Egyptian patients from April 15,2020 to July 29,2020.Consecutive polymerase chain reaction-confirmed COVID-19 cases were included from four quarantine hospitals affiliated to the Egyptian ministry of health.Demographic information,laboratory characteristics,treatments,fibrosis-4(FIB-4)index,COVID-19 severity,and outcomes were recorded and compared according to the degree of liver enzyme elevation and the presence of gastrointestinal symptoms.Follow-ups were conducted until discharge or death.Regression analyses were performed to determine the independent factors affecting mortality.RESULTS This study included 547 patients,of whom 53(9.68%)died during hospitalization and 1 was discharged upon his request.Patients’mean age was 45.04±17.61 years,and 21.98%had severe or critical COVID-19.Alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were available for 430 and 428 patients,respectively.In total,26%and 32%of patients had elevated ALT and AST,respectively.Significant liver injury with ALT or AST elevation exceeding 3-fold was recorded in 21(4.91%)and 16(3.73%)patients,respectively.Male gender,smoking,hypertension,chronic hepatitis C,and lung involvement were associated with elevated AST or ALT.AST was elevated in 50%of patients over 60-years-old.FIB-4 was significantly higher in patients admitted to the intensive care unit(ICU),those with more severe COVID-19,and non-survivors.The independent variables affecting outcome were supplementary vitamin C intake(1 g daily capsules)[odds ratio(OR):0.05,95%confidence interval(CI):0.008–0.337];lung consolidation(OR:4.540,95%CI:1.155–17.840);ICU admission(OR:25.032,95%CI:7.110–88.128);and FIB-4 score>3.25(OR:10.393,95%CI:2.459-43.925).Among 60(13.98%)patients with gastrointestinal symptoms,52(86.67%)had diarrhoea.Patients with gastrointestinal symptoms were predominantly females with higher body mass index,and 50(83.40%)patients had non-severe COVID-19.CONCLUSION Few Egyptian patients with COVID-19 developed a significant liver injury.The independent variables affecting mortality were supplementary vitamin C intake,lung consolidation,ICU admission,and FIB-4 score. | Hend Ibrahim Shousha Shimaa Afify Rabab Maher Noha Asem Eman Fouad Ehab F Mostafa Mohammed A Medhat Amr Abdalazeem Hazem Elmorsy Miriam M Aziz Rateba S Mohammed Mohamed Ibrahem Hassan Elgarem Dalia Omran Mohamed Hassany Bassem Elsayed Ahmed Y Abdelaziz Mohamed El Kassas | 2021 | World Journal of Gastroenterology2021，27，40： | 1 |
| 4 | Development of Social Media Analytics System for Emergency Event Detection and Crisis Management显示文摘Social media platforms have proven to be effective for information gathering during emergency events caused by natural or human-made disasters.Emergency response authorities,law enforcement agencies,and the public can use this information to gain situational awareness and improve disaster response.In case of emergencies,rapid responses are needed to address victims’requests for help.The research community has developed many social media platforms and used them effectively for emergency response and coordination in the past.However,most of the present deployments of platforms in crisis management are not automated,and their operational success largely depends on experts who analyze the information manually and coordinate with relevant humanitarian agencies or law enforcement authorities to initiate emergency response operations.The seamless integration of automatically identifying types of urgent needs from millions of posts and delivery of relevant information to the appropriate agency for timely response has become essential.This research project aims to develop a generalized Information Technology(IT)solution for emergency response and disaster management by integrating social media data as its core component.In this paper,we focused on text analysis techniques which can help the emergency response authorities to filter through the sheer amount of information gathered automatically for supporting their relief efforts.More specifically,we applied state-of-the-art Natural Language Processing(NLP),Machine Learning(ML),and Deep Learning(DL)techniques ranging from unsupervised to supervised learning for an in-depth analysis of social media data for the purpose of extracting real-time information on a critical event to facilitate emergency response in a crisis.As a proof of concept,a case study on the COVID-19 pandemic on the data collected from Twitter is presented,providing evidence that the scientific and operational goals have been achieved. | Shaheen Khatoon Majed AAlshamari Amna Asif Md Maruf Hasan Sherif Abdou Khaled Mostafa Elsayed Mohsen Rashwan | 2021 | Computers, Materials & Continua2021，，9： | 0 |
| 5 | A Multi-Factor Authentication-Based Framework for Identity Management in Cloud Applications显示文摘User’s data is considered as a vital asset of several organizations.Migrating data to the cloud computing is not an easy decision for any organization due to the privacy and security concerns.Service providers must ensure that both data and applications that will be stored on the cloud should be protected in a secure environment.The data stored on the public cloud will be vulnerable to outside and inside attacks.This paper provides interactive multi-layer authentication frameworks for securing user identities on the cloud.Different access control policies are applied for verifying users on the cloud.A security mechanism is applied to the cloud application that includes user registration,granting user privileges,and generating user authentication factor.An intrusion detection system is embedded to the security mechanism to detect malicious users.The multi factor authentication,intrusion detection,and access control techniques can be used for ensuring the identity of the user.Finally,encryption techniques are used for protecting the data from being disclosed.Experimental results are carried out to verify the accuracy and efficiency of the proposed frameworks and mechanism.The results recorded high detection rate with low false positive alarms. | Wael Said Elsayed Mostafa M.M.Hassan Ayman Mohamed Mostafa | 2022 | Computers, Materials & Continua2022，，5： | 0 |
| 6 | Physical properties of three short period close binaries:KIC 2715417,KIC 6050116 and KIC 6287172显示文摘We present the physical parameters of three short period close binaries using data observed from the Kepler Space Telescope. All of these observations were taken in a single bandpass(which approximates the Johnson V-band). Our three systems are KIC 2715417, KIC 6050116 and KIC 6287172. The first system, KIC 2715417, is considered a semi-detached system with the secondary component filling its Roche lobe. The second system, KIC 6050116, is an overcontact system, while the third system, KIC 6287172, belongs to ellipsoidal variables as deduced from the Roche lobe geometry. For photometric analysis, we used the PHOEBE software package, which is based on the Wilson-Devinney code. Due to lack of spectroscopic data, the photometric mass ratios are determined from the analyses of light curves using the q-search method. The absolute parameters are determined using three different methods(Harmanec, Maceroni &Van'tVeer and Gazeas & Niarchos). | Mahmoud AbdelFattah NegmEldin Ahmed Essam Elsayed Shahinaz Mostafa Yousef | 2019 | Research in Astronomy and Astrophysics2019，19，2： | 0 |
| 7 | Model Order Reduction of Complex Airframes Using Component Mode Synthesis for Dynamic Aeroelasticity Load Analysis显示文摘 | Paul V. Thomas Mostafa S. A. Elsayed Denis Walch | 2018 | Journal of Mechanics Engineering and Automation2018，8，4： | 0 |
| 8 | Biliary fistula and late recurrence of liver hydatid cyst:Role of cystobiliary communication:A prospective multicenter study显示文摘BACKGROUND Hydatid cyst disease(HCD)is common in certain locations.Surgery is associated with postoperative biliary fistula(POBF)and recurrence.The primary aim of this study was to identify whether occult cysto-biliary communication(CBC)can predict recurrent HCD.The secondary aim was to assess the role of cystic fluid bilirubin and alkaline phosphatase(ALP)levels in predicting POBF and recurrent HCD.AIM To identify whether occult CBC can predict recurrent HCD.The secondary aim was to assess the role of cystic fluid bilirubin and ALP levels in predicting POBF and recurrent HCD.METHODS From September 2010 to September 2016,a prospective multicenter study was undertaken involving 244 patients with solitary primary superficial stage cystic echinococcosis 2 and cystic echinococcosis 3b HCD who underwent laparoscopic partial cystectomy with omentoplasty.Univariable logistic regression analysis assessed independent factors determining biliary complications and recurrence.RESULTS There was a highly statistically significant association(P≤0.001)between cystic fluid biochemical indices and the development of biliary complications(of 16 patients with POBF,15 patients had high cyst fluid bilirubin and ALP levels),where patients with high bilirubin-ALP levels were 3405 times more likely to have biliary complications.There was a highly statistically significant association(P≤0.001)between biliary complications,biochemical indices,and the occurrence of recurrent HCD(of 30 patients with recurrent HCD,15 patients had high cyst fluid bilirubin and ALP;all 16 patients who had POBF later developed recurrent HCD),where patients who developed biliary complications and high bilirubin-ALP were 244.6 and 214 times more likely to have recurrent hydatid cysts,respectively.CONCLUSION Occult CBC can predict recurrent HCD.Elevated cyst fluid bilirubin and ALP levels predicted POBF and recurrent HCD. | Tamer A A M Habeeb Mauro Podda Boris Tadic Vishal G Shelat Yaman Tokat Mohamed Ibrahim Abo Alsaad Abd-Elfattah Kalmoush Mohammed Shaaban Nassar Fawzy Metwally Mustafa Mahmoud Hassib Morsi Badawy Mohamed Sobhy Shaaban Tarek Zaghloul Mohamed Mohammed Ibrahim El Sayed Henish Hamdi Elbelkasi Mahmoud Abdou Yassin Abdelshafy Mostafa Amr Ibrahim Waleed A-Abdelhady TamerMohamed Elshahidy Mohamed Ibrahim Mansour Adel Mahmoud Moursi Mohamed Abdallah Zaitoun EhabShehata Abd-Allah Ashraf Abdelmonem Elsayed Rasha S Elsayed Ahmed M Yehia Amr Abdelghani Mohamed Negm Heba Alhussein Abo-Alella Mostafa M Elaidy | 2023 | World Journal of Methodology2023，13，4： | 0 |
| 9 | Evaluating the influence of a structured nursing protocol on targeted outcomes in rheumatoid arthritis patients显示文摘Objective:Rheumatoid arthritis(RA)requires comprehensive management.Structured nursing protocols may enhance outcomes,but evidence is limited.This study evaluated the effect of a structured nursing protocol on RA outcomes.Materials and Methods:In this one-group pre-post study,30 Egyptian RA patients completed assessments before and after a 12-week nursing protocol comprising education,psychosocial support,and self-management promotion.Assessments included clinical evaluation of joint counts,erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP)and patient-reported Arthritis Self-Efficacy Scale(ASES),Health Assessment Questionnaire(HAQ),Visual Analog Scale(VAS)for pain,and Hospital Anxiety and Depression Scale(HADS).Results:The study demonstrated significant improvements in both clinical-and patient-reported outcomes.Joint count decreased from 18.4±4.2 to 14.2±3.8(P<0.001),ESR from 30.1±6.8 mm/h to 25.5±6.8 mm/h(P<0.01),and CRP levels from 15.2±3.6 mg/L to 11.8±2.9 mg/L(P<0.01)postintervention.Patient-reported outcomes showed a marked increase in ASES score from 140±25 to 170±30(P<0.001)and reductions in HAQ from 1.6±0.4 to 1.3±0.3(P<0.01),VAS pain score from 7.8±1.7 to 6.2±1.2(P<0.001),and HADS anxiety and depression scores from 11±3 to 8±2(P<0.05)and 10±2 to 7±1(P<0.05),respectively.Conclusion:A structured nursing protocol significantly improved clinical disease activity,physical functioning,pain,self-efficacy,and emotional well-being in RA patients.A multifaceted nursing intervention appears beneficial for optimizing RA outcomes. | Mohammed Elsayed ZAKY Shimaa Magdi FARGHALY Osama Mohamed Elsayed RAMADAN Rehab M.ABDELKADER Mostafa SHABAN | 2024 | Journal of Integrative Nursing2024，6，1： | 0 |
| 10 | Multi-Task Learning Model with Data Augmentation for Arabic Aspect-Based Sentiment Analysis显示文摘Aspect-based sentiment analysis(ABSA)is a fine-grained process.Its fundamental subtasks are aspect termextraction(ATE)and aspect polarity classification(APC),and these subtasks are dependent and closely related.However,most existing works on Arabic ABSA content separately address them,assume that aspect terms are preidentified,or use a pipeline model.Pipeline solutions design different models for each task,and the output from the ATE model is used as the input to the APC model,which may result in error propagation among different steps because APC is affected by ATE error.These methods are impractical for real-world scenarios where the ATE task is the base task for APC,and its result impacts the accuracy of APC.Thus,in this study,we focused on a multi-task learning model for Arabic ATE and APC in which the model is jointly trained on two subtasks simultaneously in a singlemodel.This paper integrates themulti-task model,namely Local Cotext Foucse-Aspect Term Extraction and Polarity classification(LCF-ATEPC)and Arabic Bidirectional Encoder Representation from Transformers(AraBERT)as a shred layer for Arabic contextual text representation.The LCF-ATEPC model is based on a multi-head selfattention and local context focus mechanism(LCF)to capture the interactive information between an aspect and its context.Moreover,data augmentation techniques are proposed based on state-of-the-art augmentation techniques(word embedding substitution with constraints and contextual embedding(AraBERT))to increase the diversity of the training dataset.This paper examined the effect of data augmentation on the multi-task model for Arabic ABSA.Extensive experiments were conducted on the original and combined datasets(merging the original and augmented datasets).Experimental results demonstrate that the proposed Multi-task model outperformed existing APC techniques.Superior results were obtained by AraBERT and LCF-ATEPC with fusion layer(AR-LCF-ATEPC-Fusion)and the proposed data augmentation word embedding-based method(FastText)on the combined dataset. | Arwa Saif Fadel Osama Ahmed Abulnaja Mostafa Elsayed Saleh | 2023 | Computers, Materials & Continua2023，，5： | 0 |
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