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| 1 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 2 | Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic E. coli显示文摘Background: There is growing evidence to support the beneficial effects of supplementing direct-fed microbials(DFM) on performance, health status, and immune responses of weaned pigs. Therefore, the objective of this study was to investigate dietary supplementation of Bacillus subtilis(DSM 25841) on growth performance, diarrhea, gut permeability and immunity of weaned pigs experimentally infected with a pathogenic F-18 Escherichia coli(E. coli).Results: The F18 E. coli infection reduced(P < 0.05) growth performance and intestinal villi height, whereas increased(P < 0.05) diarrhea and transcellular and paracellular permeability in the jejunum compared with non-challenged control. Supplementation of Bacillus subtilis linearly enhanced average daily gain of E. coli infected pigs from d 0 to 5 post-inoculation(PI)(P < 0.05) and d 0 to 11 PI(P = 0.058). Supplementation of high dose of Bacillus subtilis reduced(P < 0.05) both transcellular and paracellular permeability on d 5 and d11 PI compared with the E. coli infected pigs fed with control diet. E. coli infection up-regulated(P < 0.05)the m RNA expression of SLC5 A10(soluble carrier family 5 member 10) and MUC2(mucin 2) on d 5 PI, but down-regulated(P < 0.05) expression of SLC5 A10, MUC2, and CLDN1 on d 11 PI in jejunal mucosa when pigs were fed with the control diet. Supplementation of Bacillus subtilis linearly up-regulated(P < 0.05) the m RNA expression of CFTR and ZO1 on d 5 PI and SLC5 A10 and MUC2 on d 11 PI in jejunal mucosa of E. coli infected pigs. In addition, E. coli infection increased(P < 0.05) the m RNA expression of several immune genes(IL1 A, IL1 B, and IL7 on d 5 PI, and IL1 B, IL6, IL7, and TNF on d 11 PI) in the ileal mucosa of weaned pigs. Inclusion of Bacillus subtilis to control diet linearly down-regulated gene expression of IL1 A on d 5 PI(P = 0.07) and IL6 on d 11 PI(P < 0.05) in ileal mucosa of E. coli infected pigs.Conclusions: Supplementation of Bacillus subtilis(DSM 25841) enhanced growth rate and improved gut barrier function of weaned pigs experimentally infected with a pathogenic E. coli. | Kwangwook Kim Yijie He Xia Xiong Amy Ehrlich Xunde Li Helen Raybould Edward R.Atwill Elizabeth A.Maga Jens JΦrgensen Yanhong Liu | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 3 |
| 3 | Serotonin receptors expressed by myelinating Schwann cells in rat sciatic nerve 显示文摘 | Elizabeth JY Hadassah T Mark HE | 1997 | Brain Research1997，753，2： | 1 |
| 4 | Transient isolated lesion of the splenium associated with clinically mild influenza encephalitis显示文摘 | Ganapathy S Elizabeth HE Wolfson BJ | 2008 | Pediatr Radiol2008，38，11： | 1 |
| 5 | Conversion of effector CD4^(+)T cells to a CD8^(+)MHC Ⅱ-recognizing lineage显示文摘CD4^(+)and CD8^(+)T cells are dichotomous lineages in adaptive immunity.While conventionally viewed as distinct fates that are fixed after thymic development,accumulating evidence indicates that these two populations can exhibit significant lineage plasticity,particularly upon TCR-mediated activation.We define a novel CD4^(-)CD8αβ^(+)MHC Ⅱ-recognizing population generated by lineage conversion from effector CD4^(+)T cells.CD4-CD8αβ^(+)effector T cells downregulated the expression of T helper cell-associated costimulatory molecules and inaeased the expression of cytotoxic T lymphocyte-associated cytotoxic molecules.This shift in functional potential corresponded with a CD8^(+)-lineage skewed transcriptional profile.TCRβ repertoire sequencing and in vivo genetic lineage tracing in acutely infected wild-type mice demonstrated that CD4^(-)CD8αβ^(+)effector T cells arise from fundamental lineage reprogramming of bona fide effector CD4^(+)T cells.Impairing autophagy via functional deletion of the initiating kinase Vps34 or the downstream enzyme Atg7 enhanced the generation of this cell population.These findings suggest that effector CD4^(+)T cells can exhibit a previously unreported degree of skewing towards the CD8^(+)T cell lineage,which may point towards a novel direction for HIV vaccine design. | Elizabeth Robins Ming Zheng Qingshan Ni Siqi Liu Chen Liang Baojun Zhang Jian Guo Yuan Zhuang You-Wen He Ping Zhu Ying Wan Qi-Jing Li | 2021 | Cellular & Molecular Immunology2021，18，1： | 1 |
| 6 | Antimicrobial activity of polysiloxane coatings containing quaternary ammonium-functionalized polyhedral oligomeric silsesquioxane显示文摘 | Partha Majumdar Jie He Elizabeth Lee Alekhya Kallam Nathan Gubbins Shane J. Stafslien Justin Daniels Bret J. Chisholm | 2010 | Journal of Coatings Technology and Research2010，，4： | 1 |
| 7 | The outcome of group parent training for families of children with attention-deficit hyperactivity disorder and defiant/aggressive behavior 显示文摘 | Danforth JS Elizabeth HE Ulaszek WR | 2006 | J Behav Ther & Exp Psyehiat2006，37，： | 1 |
| 8 | Utilizing bimetallic catalysts to mitigate coke formation in dry reforming of methane显示文摘Dry reforming of methane(DRM) involves the conversion of carbon dioxide(CO_(2)) and methane(CH_(4)) into syngas(a mixture of hydrogen, H_(2), and carbon monoxide, CO), which can then be used to produce a wide range of products by means of Fischer–Tropsch synthesis. DRM has gained much attention as a means of mitigating damage from anthropogenic greenhouse gas(GHGs) emissions to the environment and instead utilizing these gases as precursors for value-added chemicals or to synthesize sustainable fuels and chemicals. Carbon deposition or coke formation, a primary cause of catalyst deactivation, has proven to be a major challenge in the development of DRM catalysts. The use of nickel-and cobalt-based catalysts has been extensively explored for DRM for their high activity and low cost but suffer from poor stability due to coke formation that has hindered their commercialization. Numerous articles have reviewed the various aspects of catalyst deactivation and strategies for mitigation, but few has focused on the benefit of bimetallic catalysts for mitigating coke formation. Bimetallic catalysts, often improve the catalytic stability over their monometallic counterparts due to synergistic effects resulting from two metal-tometal interactions. This review will cover DRM literature for various bimetallic catalyst systems, including the effect of supports and promoters, on the mitigation of carbonaceous deactivation. | Jaylin Sasson Bitters Tina He Elizabeth Nestler Sanjaya D.Senanayake Jingguang G.Chen Cheng Zhang | 2022 | Journal of Energy Chemistry2022，31，5： | 1 |
| 9 | Comparative analysis of clinicopathologic features, treatment, and survival of Asian women with a breast cancer diagnosis residing in the United States显示文摘 | Min Yi Peijun Liu Xu Li Elizabeth A. Mittendorf Jianjun He Yu Ren Khazi Nayeemuddin Kelly K. Hunt | 2012 | Cancer2012，，17： | 1 |
| 10 | Oxidized CaMKII causes cardiac sinus node dysfunction in mice显示文摘 | Swaminathan Paari Dominic Purohit Anil Soni Siddarth Voigt Niels Singh Madhu V Glukhov Alexey V Gao Zhan He B Julie Luczak Elizabeth D Joiner Mei-ling A Kutschke William Yang Jinying Donahue J Kevin Weiss Robert M Grumbach Isabella M Ogawa | 2011 | Journal of Clinical Investigation2011，，8： | 1 |
| 11 | Exome Sequencing Followed by Large-Scale Genotyping Suggests a Limited Role for Moderately Rare Risk Factors of Strong Effect in Schizophrenia显示文摘 | Anna C. Need Joseph P. McEvoy Massimo Gennarelli Erin L. Heinzen Dongliang Ge Jessica M. Maia Kevin V. Shianna Min He Elizabeth T. Cirulli Curtis E. Gumbs Qian Zhao C. Ryan Campbell Linda Hong Peter Rosenquist Anu Putkonen Tero Hallikainen Eila Repo-Tiiho | 2012 | The American Journal of Human Genetics2012，，2： | 1 |
| 12 | Enhanced and tunable fluorescent quantum dots within a single crystal of protein显示文摘bio-nano 混血儿材料的设计和合成不能仅仅向新材料提供新奇性质,而且推进我们在 biomolecules 和他们的不能生活的对应物之间的相互作用的基本理解。这里,我们向由在溶解酵素蛋白质的单个晶体以内种 CdS 量点(QD ) 达到如此的一个目标汇报一条新途径。这个 bio-nano 混血儿比它没有水晶的对应物,和如此的荧光性质能是 Ag (I) 或 Hg (II ) 的增加分别地提高或压制的任何一个的射出许多更强壮的红荧光。在溶解酵素晶体以内的 CdS QD 的三维的加入被与电子断层摄影术扫描传播电子显微镜学揭示。更重要地,自从我们的途径没破坏溶解酵素晶体的水晶的性质,金属和蛋白质相互作用能被 X 光检查晶体学学习,因此在 CdS QD 形成提供卓见进 Cd (II ) 的角色。 | Hui Wei Stephen House Jiangjiexing Wu Jiong Zhang Zidong Wang Ying He Elizabeth J. Gao Yigui Gao Howard Robinson Wei Li Jianmin Zuo lan M. Robertson Yi Lu | 2013 | Nano Research2013，6，9： | 0 |
| 13 | Hepatic transcriptome profiling reveals early signatures associated with disease transition from non-alcoholic steatosis to steatohepatitis显示文摘Background and aim:Non-alcoholic fatty liver disease(NAFLD)is becoming a leading cause of chronic liver disease worldwide.The molecular events that influence disease progression from non-alcoholic fatty liver(NAFL)to aggressive non-alcoholic steatohepatitis(NASH)remain incompletely understood,leading to lack of mechanism-based targeted treatment options for NASH.This study aims to identify early signatures associated with disease progression from NAFL to NASH in mice and humans.Materials and methods:Male C57BL/6J mice were fed a high-fat,-cholesterol,and-fructose(HFCF)diet for up to 9 months.The extent of steatosis,inflammation,and fibrosis was evaluated in liver tissues.Total RNA sequencing(RNA-seq)was conducted to determine liver transcriptomic changes.Results:After being fed the HFCF diet,mice sequentially developed steatosis,early steatohepatitis,steatohepatitis with fibrosis,and eventually spontaneous liver tumor.Hepatic RNA-seq revealed that the key signatures during steatosis progression to early steatohepatitis were pathways related to extracel-lular matrix organization and immune responses such as T cell migration,arginine biosynthesis,C-type lectin receptor signaling,and cytokine-cytokine receptor interaction.Genes regulated by transcription factors forkhead box M1(FOXM1)and negative elongation factor complex member E(NELFE)were significantly altered during disease progression.This phenomenon was also observed in patients with NASH. | Nancy Magee Forkan Ahamed Natalie Eppler Elizabeth Jones Priyanka Ghosh Lily He Yuxia Zhang | 2022 | Liver Research2022，6，4： | 0 |
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