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| 1 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 2 | Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells显示文摘 | Saiyong Zhu Raiesh Ambasudhan Woong Sun Hyun Jung Kim Maria Talantova Xiaojing Wang Mingliang Zhang Yu Zhang Timothy Laurent James Parker Han-Seop Kim Jeffrey D Zaremba Sofiyan Saleem Sara Sanz-Blasco Eliezer Masliah Scott R McKercher Yee Sook Cho Stuart A Lipton Janghwan Kim Sheng Ding | 2014 | Cell Research2014，24，1： | 6 |
| 3 | 以色列高科技和风险投资的发展情况显示文摘20世纪90年代以来,以色列的高科技产业经历了一个规模从小到大的迅猛发展的阶段,所取得的成就令世人瞩目,这与以色列政府的大力支持和以色列风险投资的成功运作息息相关。本文具体介绍了以色列政府促进高科技产业发展的各项支持计划,以及为发展高科技产业而设立的私人风险投资基金(YOZMA基金)和公募风险投资基金(INBAL基金),并阐述了以色列风险投资业发展过程及其成果,以供借鉴。 | Eliezer Manor | 2004 | 科技管理研究2004，24，2： | 5 |
| 4 | The role of the magnesium industry in protecting the environment显示文摘 | Aghion E Bronfin B Eliezer D | 2001 | J Mater Processing Technol2001，117，： | 3 |
| 5 | Non-thermal laser driven plasma-blocks for proton boron avalanche fusion as direct drive option显示文摘Fusion energy from protons reacting with ^(11) B,HB11,is extremely difficult or impossible when using thermal ignition by laser irradiation.This changes radically when using picosecond laser pulses with powers above petawatts dominated by nonlinear force driven ultrahigh ac-celeration of plasma blocks for a non-thermal initiation of igniting solid density HB11 fuel.For a cylindrical trapping of the reaction,laser produced ultrahigh magnetic fields above kiloTesla,have to be combined.The experimentally confirmed highly increased HB11 fusion gains due to avalanche reaction may lead to a scheme of an environmentally clean and economic power reactor. | Heinrich Hora Shalom Eliezer Noaz Nissim Paraskevas Lalousis | 2017 | Matter and Radiation at Extremes2017，2，4： | 2 |
| 6 | 稀土Y对低膨胀高温合金显微组织和界面的影响(英文)显示文摘运用分析电子显微术、高分辨电子显微术、化学相分析和 X-射线衍射等方法分析研究了Fe-Ni-Co-Nb-Ti-Si低膨胀高温合金的相组成和相结构 ,以及稀土对合金的组织和性能的影响规律。结果显示 ,微量的稀土主要存在于合金的片状相中 ,并使其晶体结构发生变化。加入适量的稀土 Y后 ,合金片状相变得更加细密、均匀。和不含稀土的低膨胀高温合金相比 ,含 Y的低膨胀高温合金中片状相与基体的晶格错配由 0 .7%下降到 0 .0 7% 。 | Wang, R.-M. Han, Y.-F. Eliezer, D. | 2001 | Chinese Journal of Aeronautics2001，14，3： | 2 |
| 7 | Design,synthesis,characterization,cytotoxic and structure activity relationships of novel Ru(Ⅱ) complexes显示文摘Platinum containing compounds have shown antineoplastic potential, but their clinical applications have been limited by high toxicity. Ruthenium containing complexes have long been known to be well suited for biological applications, and have long been utilized as replacements to popular platinum based-drugs. Here, we report a novel series of ruthenium(II) arene compounds bearing thiosemicarbazone and isonicotinylhydrazone ligands with potent anticancer activity their structure activity relationships and apoptosis was studied. The cytotoxic activity of the new ruthenium(II) arene compounds has been evaluated in several cell lines(Molt 4/C8, L1210, CEM, HL60 and BEL7402). Among them, ten complexes were found to be excellent in vitro growth inhibitory activity against various cell lines with IC50 in the sub-micromolar range. | Sreekanth Thota Srujana Vallala Rajeshwar Yerra Eliezer J.Barreiro | 2015 | Chinese Chemical Letters2015，26，6： | 2 |
| 8 | The role of the magnesium industry in protecting the environment显示文摘 | E Aghion B Bronfin D Eliezer | 2001 | Journal of Materials Processing Tech2001，，3： | 2 |
| 9 | Synthesis, properties and applications of titanium aluminides显示文摘 | F. H. Froes C. Suryanarayana D. Eliezer | 1992 | Journal of Materials Science1992，，19： | 2 |
| 10 | The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis显示文摘 | Mitchell M. Levy R. Phillip Dellinger Sean R. Townsend Walter T. Linde-Zwirble John C. Marshall Julian Bion Christa Schorr Antonio Artigas Graham Ramsay Richard Beale Margaret M. Parker Herwig Gerlach Konrad Reinhart Eliezer Silva Maurene Harvey Susan Reg | 2010 | Intensive Care Medicine2010，，2： | 2 |
| 11 | The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis显示文摘 | Mitchell M. Levy R Phillip Dellinger Sean R. Townsend Walter T. Linde-Zwirble John C. Marshall Julian Bion Christa Schorr Antonio Artigas Graham Ramsay Richard Beale Margaret M. Parker Herwig Gerlach Konrad Reinhart Eliezer Silva Maurene Harvey Susan Rega | 2010 | Critical Care Medicine2010，，2： | 2 |
| 12 | Moderate to severe thrombocytopenia during pregnancy显示文摘 | Michal Parnas Eyal Sheiner Ilana Shoham-Vardi Eliezer Burstein Tikva Yermiahu Itai Levi Gershon Holcberg Ronit Yerushalmi | 2006 | European Journal of Obstetrics and Gynecology2006，，1： | 2 |
| 13 | The comeback of shock waves in inertial fusion energy显示文摘 | Shalom Eliezer Jose Maria Martinez Val | 2011 | Laser and Particle Beams2011，，2： | 2 |
| 14 | NAP protects memory,increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model显示文摘 | Natalia Shiryaev Yan Jouroukhin Eliezer Giladi | 2009 | Neurobiology of Disease2009，34，2： | 1 |
| 15 | Psychiatric disorders and behavioral problems in children with velocardiofacial syndrome: usefulness as phenotypic indicators of schizophrenia risk显示文摘 | Feinstein C Eliez S Blasey C | 2002 | Biol Psychiatry2002，51，4： | 1 |
| 16 | Magnesium science, technology and applications 显示文摘 | Eliezer D Aghion E Froes F H | 1998 | Advanced Performance Materials1998，，5： | 1 |
| 17 | Splenic littoral cell haemangioendothelioma:a new low grade vaniant of malignant littoral cell tumor显示文摘 | Ben I zhak O Bejar J Ben Eliezer S | | 0，，05： | 1 |
| 18 | The science technology and applications of magnesium显示文摘 | FROES F H AGHION E ELIEZER D | 1998 | Advanced Performance Materials1998，5，3： | 1 |
| 19 | Microstructures and dislocations in the stressed AZ91D magnesium alloys 显示文摘 | Wang R M Eliezer A Gutman E | 2002 | Materials Science and Engineering A2002，344，8： | 1 |
| 20 | Corrosion of fatigue of die cast and extruded magnesium alloys显示文摘 | ELIEZER A CUTMAN E M ABRAMOV E | 2001 | J Light Metals2001，1，3： | 1 |
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