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| 1 | Aspartate transaminase to platelet ratio index in hepatitis C virus and Schistosomiasis coinfection显示文摘AIM: To assess the diagnostic accuracy,of aminotransferase-to-platelet ratio index(APRI) alone and with antischistosomal antibody(Ab) in patients with hepatitis C virus(HCV) and schistosomiasis coinfection. METHODS: This retrospective study included medical records of three hundred and eighty three Egyptianmen patients who had undergone percutaneous liver biopsy between January 2006 to April 2014 in tertiary care hospital in Qatar for diagnosis or monitoring purpose were selected. Data of patients > 18 years of age were included in the study. The values of HCV RNA titer and antischistosomal antibody titer were also taken into consideration. Patients were excluded from the study if they had any other concomitant chronic liver disease,including; history of previous antiviral or interferon therapy,immunosuppressive,therapy,chronic hepatitis B infection,human immunodeficiency virus co-infection,autoimmune hepatitis,decompensated liver disease,hepatocellular carcinoma,prior liver transplantation,and if no data about the liver biopsy present. RESULTS: Median age of patients was 46 years. About 7.1% had no fibrosis,whereas 30.4%,37.5%,20.4%,and 4.6% had fibrosis of stage Ⅰ,Ⅱ,Ⅲ,and Ⅳ respectively. In bivariate analysis,APRI score,levels of AST,platelet count and age of patient showed statistically significant association with liver fibrosis(P < 0.0001); whereas antischistosomal antibody titer(P = 0.52) and HCV RNA titer(P = 0.79) failed to show a significant association. The respective AUC values for no fibrosis,significant fibrosis,severe fibrosis and cirrhosis of APRI score were 63%,73.2%,81.1% and 88.9% respectively. This showed good sensitivity and specificity of APRI alone for grading of liver fibrosis. But the inclusion of anti-Schistosoma antibody did not improve the prediction of fibrosis stage. CONCLUSION: The study results suggest that noninvasive biochemical markers like APRI are sensitive and specific in diagnosing the degree of fibrosis and cirrhosis in patients with coinfection of HCV and schistosomiasis as compared to biopsy. The addition of antischistosomal Ab to APRI did not improve sensitivity for predicting the degree of cirrhosis. | Moutaz Derbala Mohammed Elshiekh Elbadri Aliaa Mohamed Amer Saad Al Kaabi Khaleel Hassan Sultan Yasser Medhat Kamel Eman Hassan Satti Elsayed Tony Yervant Avades Prem Chandra Fatma M Shebl | 2015 | World Journal of Gastroenterology2015，21，46： | 2 |
| 2 | Low-density lipoprotein receptor genetic polymorphism in chronic hepatitis C virus Egyptian patients affects treatment response显示文摘AIM: To correlate a genetic polymorphism of the low-density lipoprotein(LDL) receptor with antiviral responses in Egyptian chronic hepatitis C virus(HCV) patients.METHODS: Our study included 657 HCV-infected patients with genotype 4 who received interferonbased combination therapy. Patients were divided into two groups based on their response to therapy: 356 were responders, and 301 were non-responders. Patients were compared to 160 healthy controls. All patients and controls underwent a thorough physical examination, measurement of body mass index(BMI) and the following laboratory tests: serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, albumin, total bilirubin, direct bilirubin, prothrombin time, prothrombin concentration, INR, complete blood count, serum creatinine, fasting blood sugar, HCV antibody, and hepatitis B surface antigen. All HCV patients were further subjected to the following laboratory tests: HCV-RNA using quantitative polymerase chain reaction(PCR), antinuclear antibodies, thyroid-stimulating hormone, an LDL receptor(LDLR) genotype study of LDLR exon8 c.1171G>A and exon-10 c.1413G>A using real-time PCR-based assays, abdominal ultrasonography, ultrasonographic-guided liver biopsy, and histopathological examination of liver biopsies. Correlations of LDL receptor polymorphisms with HAI, METAVIR score, presence of steatosis, and BMI were performed in all cases.RESULTS: There were no statistically significant differences in response rates between the different types of interferon used or LDLR exon10 c.1413G>A. However, there was a significant difference in the frequency of the LDL receptor exon8 c.1171G>A genotype between cases(AA: 25.9%, GA: 22.2%, GG: 51.9%) and controls(AA: 3.8%, GA: 53.1% and GG: 43.1%)(P < 0.001). There was a statistically significant difference in the frequency of the LDLR exon 8C:1171 G>A polymorphism between responders(AA: 3.6%, GA: 15.2%, GG: 81.2%) and nonresponders(AA: 52.2%, GA: 30.6%, GG: 17.2%)(P < 0.001). The G allele of LDL receptor exon8 c.1171G>A predominated in cases and controls over the A allele, and a statistically significant association with response to interferon was observed. The frequency of the LDLR exon8 c.1171G>A allele in non-responders was: A: 67.4% and G: 32.6 vs A: 11.2% and G: 88.8% in responders(P < 0.001). Therefore, carriers of the A allele exhibited a 16.4 times greater risk for nonresponse. There was a significant association between LDL receptors exon8 c.1171G>A and HAI(P < 0.011). There was a significant association between LDL receptors exon8 c.1171G>A and BMI. The mean BMI level was highest in patients carrying the AA genotype(28.7 ± 4.7 kg/m2) followed by the GA genotype(28.1 ± 4.8 kg/m2). The lowest BMI was the GG genotype(26.6 ± 4.3 kg/m2)(P < 0.001). The only significant associations were found between LDL receptors exon8 c.1171G>A and METAVIR score or steatosis(P < 0.001).CONCLUSION: LDL receptor gene polymorphisms play a role in the treatment response of HCV and the modulation of disease progression in Egyptiansinfected with chronic HCV. | Mazen Naga Mona Amin Dina Algendy Ahmed Elbadry May Fawzi Ayman Foda Serag Esmat Dina Sabry Laila Rashed Samia Gabal Manal Kamal | 2015 | World Journal of Gastroenterology2015，21，39： | 2 |
| 3 | Friction and wear of copper-graphite composites made with Cu-coated and uncoated graphite powders 显示文摘 | MOUSTAFA S F ELBADRY S A SANAD A M | 2002 | Wear2002，253，78： | 1 |
| 4 | Extracorporeal shock wave lithotripsy as first line treatment for urinary tract stones in children: outcome of 500 cases显示文摘 | Abdelbasset Badawy Mohamed Saleem Ahmad Abolyosr Mohamed Aldahshoury Mohamed Elbadry Medhat Abdalla Abdelmoneim Abuzeid | 2012 | International Urology and Nephrology2012，，： | 1 |
| 5 | Temperature Variations in Concrete Bridges 显示文摘 | ELBADRY M M GHALI A | 1983 | Journal of Structual Engineeing ASCE1983，109，10： | 1 |
| 6 | Temperature variations in concrete bridges 显示文摘 | Elbadry M Ghali A | 1993 | Journal of Structural Engineering ASCE1993，109，10： | 1 |
| 7 | Manage- ment of the facial nerve in lateral skull base surgery ana lytic retrospective study显示文摘 | E1 Shazly MA Mokbel MA Elbadry AA | 2011 | Clin Med Insights Ear Nose Throat2011，4，2： | 1 |
| 8 | Temperature variations in concrete bridges显示文摘 | Elbadry M M Ghail A | | 0，，10： | 1 |
| 9 | Mo1016 Prospective Randomized Controlled Study of Radiofrequency Ablation and Partial Splenic Embolization in the Treatment of Hypersplenism in Patients With Post-Hepatitis C Cirrhosis显示文摘 | Wasfy E S A Elbadry A Abdel Baset M H | 2014 | Gastroenterology2014，5，146： | 1 |
| 10 | Temperature variations in concrete bridges显示文摘 | Elbadry M M Ghali A | 1983 | Journal of Structural Engineering1983，109，10： | 1 |
| 11 | Intraspecific variation in isolates assessed with restriction fragment length polymorphism and DNA sequencing of the internal transcribed spacer region of the ribosomal RNA cistron 显示文摘 | ELBADRI G A A PENT D E WAEYENBERGE L | 2002 | International Journal for Parasitology2002，32，： | 1 |
| 12 | Morphological differ- ences among Radopholus similis (Cobb, 1893) Thorne, 1949 populations显示文摘 | Elbadri G A A Geraert E Moens M | 1999 | Russian Journal of Nematode1999，7，2： | 1 |
| 13 | Temperature variations in Concretebridges 显示文摘 | MM Elbadry A Ghali | 1983 | Journal of Structural Engineering ASCE1983，109，10： | 1 |
| 14 | Temperature variations in concrete bridges显示文摘 | ELBADRY M M GHAIL A | 1983 | Journal of the Structural Engineering ASCE1983，109，10： | 1 |
| 15 | Temperature variations in con- crete bridges 显示文摘 | Elbadry M M Ghall A | 1983 | Journal of Structural Engineering ASCE1983，109，10： | 1 |
| 16 | Control of Thermal Cracking of Concrete Structures显示文摘 | Elbadry M Ghali A | 1995 | AC1 Journal1995，，7： | 1 |
| 17 | Temperature Variation in Concrete Bridges显示文摘 | Elbadry M Ghalli A | 1983 | Journal of Structural Engineering ASCE1983，109，10： | 1 |
| 18 | The distribution of neuropeptides in the ocular tissues of several mammals: a comparative study显示文摘 | Elbadri AA Shaw C Johnston CF | 1991 | Comp Biochem Physiol C1991，100，3： | 1 |
| 19 | Temperature variations in concrete bridges 显示文摘 | Elbadry M Ghali A | 1983 | Journal of Structural Engineering ASCE1983，109，10： | 1 |
| 20 | Control of cracking due to temperature in structure concrete reinforced with CFRP bars 显示文摘 | Mamdouh Elbadry & Omer Elzaroug | 2003 | Composite Structures2003，，64： | 1 |
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