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| 1 | Retrospective cohort study Lower incidence of complications in endoscopic nasobiliary drainage for hilar cholangiocarcinoma显示文摘AIM:To identify the most effective endoscopic biliary drainage technique for patients with hilar cholangiocarcinoma.METHODS:In total,118 patients with hilar cholangiocarcinoma underwent endoscopic management[endoscopic nasobiliary drainage(ENBD)or endoscopic biliary stenting]as a temporary drainage in our institution between 2009 and 2014.We retrospectively evaluated all complications from initial endoscopic drainage to surgery or palliative treatment.The risk factors for biliary reintervention,post-endoscopic retrograde cholangiopancreatography(post-ERCP)pancreatitis,and percutaneous transhepatic biliary drainage(PTBD)were also analyzed using patient-and procedure-related characteristics.The risk factors for bilateral drainage were examined in a subgroup analysis of patients who underwent initial unilateral drainage.RESULTS:In total,137 complications were observed in92(78%)patients.Biliary reintervention was required in 83(70%)patients.ENBD was significantly associated with a low risk of biliary reintervention[odds ratio(OR)=0.26,95%CI:0.08-0.76,P=0.012].Post-ERCP pancreatitis was observed in 19(16%)patients.An absence of endoscopic sphincterotomy was significantly associated with post-ERCP pancreatitis(OR=3.46,95%CI:1.19-10.87,P=0.023).PTBD was required in 16(14%)patients,and Bismuth type III or IV cholangiocarcinoma was a significant risk factor(OR=7.88,95%CI:1.33-155.0,P=0.010).Of 102 patients with initial unilateral drainage,49(48%)required bilateral drainage.Endoscopic sphincterotomy(OR=3.24,95%CI:1.27-8.78,P=0.004)and Bismuth II,III,or IV cholangiocarcinoma(OR=34.69,95%CI:4.88-736.7,P<0.001)were significant risk factors for bilateral drainage.CONCLUSION:The endoscopic management of hilar cholangiocarcinoma is challenging.ENBD should be selected as a temporary drainage method because of its low risk of complications. | Kazumichi Kawakubo Hiroshi Kawakami Masaki Kuwatani Shin Haba Taiki Kudo Yoko A Taya Shuhei Kawahata Yoshimasa Kubota Kimitoshi Kubo Kazunori Eto Nobuyuki Ehira Hiroaki Yamato Manabu Onodera Naoya Sakamoto | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，9： | 26 |
| 2 | Three cases of retroperitoneal schwannoma diagnosed by EUS-FNA显示文摘Schwannomas are peripheral nerve tumors that are typically solitary and benign.Their diagnosis is largely based on surgically resected specimens.Recently,a number of case reports have indicated that retroperitoneal schwannomas could be diagnosed with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA).We report the diagnosis of three cases of schwannoma using EUS-FNA.Subjects were two males and one female,ages 22,40,and 46 years,respectively,all of whom were symptom-free.Imaging findings showed well-circumscribed round tumors.However,as the tumors could not be diagnosed using these findings alone,EUS-FNA was performed.Hematoxylin-eosin staining of the resulting tissue fragments revealed bland spindle cells with nuclear palisading.There was no disparity in nuclear sizes.Immunostaining revealed S-100 protein positivity and all cases were diagnosed as schwannomas.Ki-67 indexes were 3%-15%,2%-3%,and 3%,respectively.No case showed any signs of malignancy.As most schwannomas are benign tumors and seldom become malignant,we observed these patients without therapy.All tumors demonstrated no enlargement and no change in characteristics.Schwannomas are almost always benign and can be observed following diagnosis by EUS-FNA. | Taiki Kudo Hiroshi Kawakami Masaki Kuwatani Nobuyuki Ehira Hiroaki Yamato Kazunori Eto Kanako Kubota Masahiro Asaka | 2011 | World Journal of Gastroenterology2011，17，29： | 8 |
| 3 | Influence of the safety and diagnostic accuracy of preoperative endoscopic ultrasound-guided fine-needle aspiration for resectable pancreatic cancer on clinical performance显示文摘AIM:To evaluate the safety and diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)in a cohort of pancreatic cancer patients.METHODS:Of 213 patients with pancreatic cancer evaluated between April 2007 and August 2011,82were thought to have resectable pancreatic cancer on the basis of cross-sectional imaging findings.Of these,54 underwent EUS-FNA before surgery(FNA+group)and 28 underwent surgery without preoperative EUSFNA(FNA-group).RESULTS:All 54 lesions were visible on EUS,and all54 attempts at FNA were technically successful.The diagnostic accuracy according to cytology and histology findings was 98.1%(53/54)and 77.8%(42/54),respectively,and the total accuracy was 98.1%(53/54).One patient developed mild pancreatitis after EUS-FNA but was successfully treated by conservative therapy.No severe complications occurred after EUS-FNA.In the FNA+and FNA-groups,the median relapse-free survival(RFS)was 742 and 265 d,respectively(P=0.0099),and the median overall survival(OS)was1042 and 557 d,respectively(P=0.0071).RFS and OS were therefore not inferior in the FNA+group.These data indicate that the use of EUS-FNA did not influence RFS or OS,nor did it increase the risk of peritoneal recurrence.CONCLUSION:In patients with resectable pancreatic cancer,preoperative EUS-FNA is a safe and accurate diagnostic method. | Taiki Kudo Hiroshi Kawakami Masaki Kuwatani Kazunori Eto Shuhei Kawahata Yoko Abe Manabu Onodera Nobuyuki Ehira Hiroaki Yamato Shin Haba Kazumichi Kawakubo Naoya Sakamoto | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 4 | Electronic conductivity measurement of Sm-and La-doped ceri;ceramics by Hebb-Wagner meathod显示文摘 | SHIMONOSONO T HIRATA Y EHIRA Y | 2004 | Solid State Ionics2004，174，14： | 1 |
| 5 | Impact Wear Characteristics of Engine Valve and Valve Seat Materials at High Temperature 显示文摘 | Ootani T Yahata N Fujiki A Ehira A | 1995 | Wear1995，，188： | 1 |
| 6 | Changes in the amount of cellular trehalose, the activity of mahooligosyl trehalose hydrolase, and the expression of its gene in response to salt stress in the cyanobacterium Spirulinaplatensis 显示文摘 | Ohmori K Ehira S Kimura S | 2009 | Microbes and Environments2009，24，1： | 1 |
| 7 | Mechanical proerties and microstructures of submicron cermets 显示文摘 | EHIRA M EGAMI A | 1995 | Int ofRM & HM1995，，13： | 1 |
| 8 | Mechanical properties and microstructures of Submicron cermets 显示文摘 | Ehira M Egami A | 1995 | International Journal of Refractory Metals&Hard Materials1995，13，： | 1 |
| 9 | Effects of graded compression and nucleus pulposus on nerve tissue:an experiment study in rabbits显示文摘 | Rydevik B Brown MD Ehira T | 1983 | Acta Orthop Scand1983，54，： | 1 |
| 10 | Changes in the Amount ofCellular Trehalose,the Activity of Maltooligosyl TrehaloseHydrolase, and the Expression of Its Gene in Response to SaltStress in the Cyanobacterium Spirulina platensis 显示文摘 | Ohmori K Ehira S Kimura S | 2009 | Microbesand Environments2009，24，1： | 1 |
| 11 | Electronic conduc-tivity measurement of Sm- and La-doped ceria ceramics by Hebb-Wagner method显示文摘 | Shimonosono T Hirata Y Ehira Y | | 0，，1： | 1 |
| 12 | Electronic conductivity measurement of Smand La-doped ceria ceramics by Hebb-Wagner method 显示文摘 | SHIMONOSONO T HIRATA Y EHIRA Y | 2004 | Solid State Ionics2004，174，14： | 1 |
| 13 | Mechanical properties and microstructure of submicron cermets显示文摘 | Ehira M Egami A | 1995 | International Journal of Refractory Metals and Hard Materials1995，13，5： | 1 |
| 14 | Mechanical properties and microstructures of submicron cermets显示文摘 | Ehira M Egami A | 1995 | International Journal of Refractory Metals and Hard Materials1995，13，5： | 1 |
| 15 | Freshness-lowering rate of cod and csea bream viewed from changes in bacterial count,total volatile base and trimethylamine-nitrogen,and ATP related compounds显示文摘 | Ehira S Uchiyama H | | 0，，05： | 1 |
| 16 | Mechanical properties and microstructures of submicron cermets显示文摘 | EGAMI A | 1995 | International Journal of Refractory Metals and Hard Materials1995，13，5： | 1 |
| 17 | Molecular phylogeny and evolution of the plastid and nuclear encoded cbbX genes in the unicellular red alga Cyanidioschyzon mero- lae 显示文摘 | Fujita K Ehira S Tanaka K | 2008 | Genes & Genetic Systems2008，83，2： | 1 |
| 18 | Changes in viable bacterial count of sardine during partially frozen storage显示文摘 | Ehira S Fujii T | 1980 | Bulletin of the Japanese Society of Scientific Fisheries1980，46，11： | 1 |
| 19 | Mechanical Properties and Microstructures of Submicron Cermets显示文摘 | Ehira M Egami A | 1995 | International Journal of Refractory Metals & Hard Materials1995，13，： | 1 |
| 20 | Mechanical properties and microstructure of submicron cermets显示文摘 | Ehira M Egami A | 1995 | International Journal of Refractory Metals and Hard Materials1995，13，5： | 1 |
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