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| 1 | Probiotics in hepatology:An update显示文摘The gut-liver axis plays an important role in the pathogenesis of various liver diseases.Probiotics are living bacteria that may be used to correct disorders of this axis.Notable progress has been made in the study of probiotic drugs for the treatment of various liver diseases in the last decade.It has been proven that probiotics are useful for hepatic encephalopathy,but their effects on other symptoms and syndromes of cirrhosis are poorly studied.Their effectiveness in the treatment of metabolic associated fatty liver disease has been shown both in experimental models and in clinical trials,but their effect on the prognosis of this disease has not been described.The beneficial effects of probiotics in alcoholic liver disease have been shown in many experimental studies,but there are very few clinical trials to support these findings.The effects of probiotics on the course of other liver diseases are either poorly studied(such as primary sclerosing cholangitis,chronic hepatitis B and C,and autoimmune hepatitis)or not studied at all(such as primary biliary cholangitis,hepatitis A and E,Wilson's disease,hemochromatosis,storage diseases,and vascular liver diseases).Thus,despite the progress in the study of probiotics in hepatology over the past decade,there are many unexplored and unclear questions surrounding this topic. | Roman Maslennikov Vladimir Ivashkin Irina Efremova Elena Poluektova Elena Shirokova | 2021 | World Journal of Hepatology2021，13，9： | 2 |
| 2 | Gut dysbiosis and small intestinal bacterial overgrowth as independent forms of gut microbiota disorders in cirrhosis显示文摘BACKGROUND Gut dysbiosis and small intestinal bacterial overgrowth(SIBO)are commonly observed in patients with cirrhosis.Despite the substantial number of articles describing the relations between disorders of gut microbiota and various manifestations of cirrhosis,dysbiosis and SIBO were always studied separately.AIM To study the relationship of gut dysbiosis and SIBO in cirrhosis.METHODS This observational study included 47 in-patients with cirrhosis.Stool microbiome was assessed using 16 S r RNA gene sequencing.SIBO was assessed using the lactulose hydrogen breath test.RESULTS SIBO was found in 24/47(51.1%)patients.Patients with SIBO had a higher abundance of Firmicutes(P=0.017)and Fusobacteria(P=0.011),and a lower abundance of Bacteroidetes(P=0.013)than patients without SIBO.This increase in the abundance of Firmicutes occurred mainly due to an increase in the abundance of bacteria from the genus Blautia(P=0.020)of the Lachnospiraceae family(P=0.047),while the abundance of other major families of this phylum[Ruminococcaceae(P=0.856),Peptostreptococcaceae(P=0.066),Clostridiaceae(P=0.463),Eubacteriaceae(P=0.463),Lactobacillaceae(P=0.413),and Veillonellaceae(P=0.632)]did not differ significantly between the patients with and without SIBO.Reduced level of Bacteroidetes in samples from patients with SIBO was a result of the decrease in bacterial numbers from all the major families of this phylum[Bacteroidaceae(P=0.014),Porphyromonadaceae(P=0.002),and Rikenellaceae(P=0.047)],with the exception of Prevotellaceae(P=0.941).There were no significant differences in the abundance of taxa that were the main biomarkers of cirrhosis-associated gut dysbiosis[Proteobacteria(P=0.790),Bacilli(P=0.573),Enterobacteriaceae(P=0.632),Streptococcaceae(P=0.170),Staphylococcaceae(P=0.450),and Enterococcaceae(P=0.873)]between patients with and without SIBO.CONCLUSION Despite the differences observed in the gut microbiome between patients with and without SIBO,gut dysbiosis and SIBO are most likely independent disorders of gut microbiota in cirrhosis. | Roman Maslennikov Vladimir Ivashkin Irina Efremova Elena Poluektova Anna Kudryavtseva George Krasnov | 2022 | World Journal of Gastroenterology2022，28，10： | 2 |
| 3 | Gut-liver axis in cirrhosis:Are hemodynamic changes a missing link?显示文摘Recent evidence suggests that the condition of the gut and its microbiota greatly influence the course of liver disease,especially cirrhosis.This introduces the concept of the gut-liver axis,which can be imagined as a chain connected by several links.Gut dysbiosis,small intestinal bacterial overgrowth,and intestinal barrier alteration lead to bacterial translocation,resulting in systemic inflammation.Systemic inflammation further causes vasodilation,arterial hypotension,and hyperdynamic circulation,leading to the aggravation of portal hypertension,which contributes to the development of complications of cirrhosis,resulting in a poorer prognosis.The majority of the data underlying this model were obtained initially from animal experiments,and most of these correlations were further reproduced in studies including patients with cirrhosis.However,despite the published data on the relationship of the disorders of the gut microbiota with the complications of cirrhosis and the proposed pathogenetic role of hemodynamic disorders in their development,the direct relations between gut dysbiosis and hemodynamic changes in this disease are poorly studied.They remain a missing link in the gut-liver axis and a challenge for future research. | Roman Maslennikov Vladimir Ivashkin Irina Efremova Elena Poluektova Elena Shirokova | 2021 | World Journal of Clinical Cases2021，9，31： | 2 |
| 4 | Electrochemical formation and deposition of polyaniline on electrode surface - in-situ Raman spectroscopical study显示文摘 | Efremova A Regis A Arsov L | 1994 | Electrochim Acta1994，39，6： | 1 |
| 5 | 显示文摘 | EFREMOVA O A MIRONOV Y V KURATIEVA N V | 2010 | Inorg Chimica Acta2010，363，： | 1 |
| 6 | Heat shock protein HSP 70 expression and DNA damage in Baikalian sponges exposed to model pollutants and wastewater from Baikalsk Pulp and Paper Plant 显示文摘 | Efremova SM Margulis BA Guzhova IV | 2002 | AquatToxicol2002，57，： | 1 |
| 7 | 远东地区大豆栽培及育种研究进展(英文)显示文摘本文对俄罗斯远东研究所在大豆栽培及育种方面的研究进展进行了总结。一方面介绍了一些通过传统育种方法选育的俄罗斯远东地区的主栽大豆品种,这些品种具有高产、高抗病性、广适、优质及熟期适宜的特点;另一方面对大豆育种中的生物及分子技术方法和应用情况进行了综述,并探讨了其发展前景。 | Chaika A K Vashchenko A P Efremova O S Ilyushko M V | 2014 | 大豆科学2014，33，5： | 1 |
| 8 | Separation of chaotic signal sum into components in the presence of noise显示文摘 | Andreyev Y V Dmitriev A S Efremova E V | 2003 | IEEE Transactions on Circuits and Systems I: Fundamental Theory and Applications2003，50，5： | 1 |
| 9 | The influence of ecdysterone on the biosynthesis of proteins and nucleic acids in mouse organs显示文摘 | Khimiko I N Mitrokinyu I Efremova O I | 2000 | Khim Farm Zh2000，34，3： | 1 |
| 10 | On the center of continuous maps of dendrites 显示文摘 | Efremova L S Makhrova E N | 2003 | J Diff Equa Appl2003，9，： | 1 |
| 11 | Identification of a new Vrn-B1 allele using Iwo near-isogenic wheat lines with difference in heading time 显示文摘 | Shcherban A B Efremova T T Salina E A | 2012 | Molecular Breeding2012，29，3： | 1 |
| 12 | Measurements of interbilayer forces and protein adsorption on uncharged lipidbilayers displaying poly (ethylene glycol) chains显示文摘 | Efremova NV Bondurant B O'Brien DF | 2000 | Biochemistry2000，39，12： | 1 |
| 13 | Immunological param- eters in the assessment of the activity of specific process in Mycobac- terium tuberculosis-infected children and patients with intrathoracic lymphatic tuberculosis显示文摘 | Efremova S N Dovgaliuk I F Sakharova IIa | 2009 | Probl Tuberk Bolezn Legk2009，，1： | 1 |
| 14 | Devel- opment of alien substitution lines of wheat with rye chromo- some 5R显示文摘 | EFREMOVA T T MAYSTRENKO O I LAYKOVA L I | 1996 | Cereal Research Communications1996，24，： | 1 |
| 15 | The development of precise genetic stocks in two wheat cultivars and their use in genetic analysis显示文摘 | V. S. Arbuzova T. T. Efremova L. I. Laikova O. I. Maystrenko O. M. Popova T. A. Pshenichnikova | 1996 | Euphytica1996，，1： | 1 |
| 16 | Separation of chaotic signal sum into components in the presence of noise显示文摘 | Andreyev Y V Dmitriev A S Efremova E V | 2003 | IEEE Trans Circuits Syst- I2003，50，5： | 1 |
| 17 | Cliniconeurophysiological features of migraine with and without aura显示文摘 | Ven AM Efremova IN Filatova EG | | 0，，： | 1 |
| 18 | A survey of tools for variant analysis of next-generation genome sequen-cing data显示文摘 | Pabinger S Dander A Fischer M Snajder R Sperk M Efremova M Krabichler B Speicher MR Zschocke J Trajanoski Z | | 0，，： | 1 |
| 19 | Effective Distribution Coefficients of Cation Impurities in KDP Crystal 显示文摘 | Efremova E P Sukhanovskaya A I Kuznetsov V A | 2004 | Inorganic Materials2004，40，： | 1 |
| 20 | Phylogenetic relationships between Lubomirskiidae, Spongillidae, and some marine sponges according partial sequences of 18SrDNA 显示文摘 | Itskovich V B Belikov S I Efremova S M & Masuda Y | 1999 | Memoirs of the Queensland Museum1999，，44： | 1 |
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