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| 1 | The neuro-glial coagulonome: the thrombin receptor and coagulation pathways as major players in neurological diseases显示文摘The neuro-glial interface extends far beyond mechanical support alone and includes interactions through coagulation cascade proteins. Here, we systematically review the evidence indicating that synaptic and node of Ranvier glia cell components modulate synaptic transmission and axonal conduction by a coagulation cascade protein system, leading us to propose the concept of the neuro-glial coagulonome. In the peripheral nervous system, the main thrombin receptor protease activated receptor 1 (PAR1) is located on the Schwann microvilli at the node of Ranvier and at the neuromuscular junction. PAR1 activation effects can be both neuroprotective or harmful, depending on thrombin activity levels. Low physiological levels of thrombin induce neuroprotective effects in the Schwann cells which are mediated by the endothelial protein C receptor. High levels of thrombin induce conduction deficits, as found in experimental autoimmune neuritis, the animal model for Guillaine-Barre syndrome. In the central nervous system, PAR1 is located on the peri-synaptic astrocyte end-feet. Its activation by high thrombin levels is involved in the pathology of primary inflammatory brain diseases such as multiple sclerosis, as well as in other central nervous system insults, including trauma, neoplasms, epilepsy and vascular injury. Following activation of PAR1 by high thrombin levels the seizure threshold is lowered. On the other hand, PAR1 activation by lower levels of thrombin in the central nervous system protects against a future ischemic insult. This review presents the known structure and function of the neuro-glial coagulonome, focusing on coagulation, thrombin and PAR1 in a pathway which may be either physiological (neuroprotective) or detrimental in peripheral nervous system and central nervous system diseases. Understanding the neuro-glial coagulonome may open opportunities for novel pharmacological interventions in neurological diseases. | Shany G.Gofrit Efrat Shavit-Stein | 2019 | Neural Regeneration Research2019，14，12： | 6 |
| 2 | Atorvastatin and rosuvastatin do not prevent thioacetamide induced liver cirrhosis in rats显示文摘AIM:To examine whether the administration of atorvastatin and rosuvastatin would prevent experimentallyinduced hepatic cirrhosis in rats.METHODS:Liver cirrhosis was induced by injections of thioacetamide(TAA).Rats were treated concurrently with TAA alone or TAA and either atorvastatin(1,10 and 20 mg/kg) or rosuvastatin(1,2.5,5,10 and 20 mg/kg) given daily by nasogastric gavage.RESULTS:Liver fibrosis and hepatic hydroxyproline content,in the TAA-treated group was significantly higher than those of the controls [11.5 ± 3.2 vs 2.6 ± 0.6 mg/g protein(P = 0.02)].There were no differences in serum aminotransferase levels in the TAA controls compared to all the groups treated concomitantly by statins.Both statins used in our study did not prevent liver fibrosis or reduce portal hypertension,and had no effect on hepatic oxidative stress.Accordingly,the hepatic level of malondialdehyde was not lower in those groups treated by TAA + statins compared to TAA only.In vitro studies,using the BrdU method have shown that atorvastatin had no effect of hepatic stellate cells proliferation.Nevertheless,statin treatment was not associated with worsening of liver damage,portal hypertension or survival rate.CONCLUSION:Atorvastatin or rosuvastatin did not inhibit TAA-induced liver cirrhosis or oxidative stress in rats.Whether statins may have therapeutic applications in hepatic fibrosis due to other etiologies deserve further investigation. | Haim Shirin Efrat Sharvit Hussein Aeed Dov Gavish Rafael Bruck | 2013 | World Journal of Gastroenterology2013，19，2： | 2 |
| 3 | Top management teams within multinational corporations: Effects of cultural heterogeneity显示文摘 | Efrat Elron | 1997 | The Leadership Quarterly1997，，4： | 2 |
| 4 | Congenital toxoplasmosis—prenatal aspects of Toxoplasma gondii infection显示文摘 | Efrat Rorman Chen Stein Zamir Irena Rilkis Hilla Ben-David | 2005 | Reproductive Toxicology2005，，4： | 2 |
| 5 | 光学检测系统的优化和评估的新方法(英文)显示文摘PCB厂商使用自动光学检测仪的目的是为了检测到重要的缺陷,而对于一些特殊设计和装饰性设计则不需要检测。如果要达到这一效果,就必须适当调整系统的检测参数。提供一种衡量AOI侦测性能的新颖方法。此种方法可以尽可能的减少漏测或误报产生的几率,通过考量漏测与误报的各自的成本,客户可据此结果来决定特定的机器的配备。关于自动检测设备选型机制示意图和方法,相关的实用工具及生产领域的简易实施方法也作了说明。 | Udi Efrat | 2004 | 电子工业专用设备2004，33，1： | 2 |
| 6 | The laryngeal mask airway in pediatric anesthesia:experience with 320 patients undergoing elective groin surgery显示文摘 | Efrat R Kadari A Katz S | 1994 | J Pediatr Surg1994，29，： | 1 |
| 7 | Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes显示文摘 | Efrat S Fejer G Brownlee M | 1995 | Proc Natl Acad Sci U S A1995，92，15： | 1 |
| 8 | Differentiation of human liver derived,insulin-producing cells toward the beta-cell phenotype显示文摘 | Zalzman M Anker-Kitai L Efrat S | 2005 | Diabetes2005，54，9： | 1 |
| 9 | Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene oncogene显示文摘 | Shimon Efrat Susanne Linde Hans Kofod | 1988 | Cell Biology1988，12，85： | 1 |
| 10 | Bartonella koehlerae,a new catassociated agent of culture-negative human endocarditis显示文摘 | Avidor B Graidy M Efrat G | 2004 | Clin Microbiol2004，42，： | 1 |
| 11 | Matching planar maps 显示文摘 | ALT H EFRAT A ROTE G | 2003 | Journal of Algorithms2003，49，： | 1 |
| 12 | Distinct Lineage Specification Roles for NANOG, OCT4, and SOX2 in Human Embryonic Stem Cells显示文摘 | Zheng Wang Efrat Oron Brynna Nelson Spiro Razis Natalia Ivanova | 2012 | Cell Stem Cell2012，，4： | 1 |
| 13 | Differentiation of human liver-derived, insulin-producing cells toward the i3-cell phenotype显示文摘 | Zalzman M Anker- Kitai L Efrat S | 2005 | Diabetes2005，54，9： | 1 |
| 14 | Distinct Lineage Specification Roles for NANOG, OCT4, and SOX2 in Human Embryonic Stem Cells显示文摘 | Zheng Wang Efrat Oron Brynna Nelson Spiro Razis Natalia Ivanova | 2012 | Cell Stem Cell2012，，4： | 1 |
| 15 | Arabidopsis immunophilins ROF1 (AtFKBP62) and ROF2 (AtFKBP65) exhibit tissue specificity, are heat-stress induced, and bind HSP90显示文摘 | Keren Aviezer-Hagai Julia Skovorodnikova Mario Galigniana Odelia Farchi-Pisanty Erez Maayan Shmuel Bocovza Yael Efrat Pascal Koskull-D?ring Nir Ohad Adina Breiman | 2007 | Plant Molecular Biology2007，，2： | 1 |
| 16 | The direct and indirect impact of culture on innovation 显示文摘 | Kalanit Efrat | 2014 | Technovation2014，34，1： | 1 |
| 17 | The residual ovary syndrome:a 20-year experience显示文摘 | DEKEL A EFRAT Z ORVIETO R | 1996 | Eur J Obstet Gynecol Reprod Biol1996，68，12： | 1 |
| 18 | Time-sensitive reversal of hyper- plasia in transgenic mice expressing SV40 T antigen显示文摘 | Ewald D Li M Efrat S | 1996 | Science1996，273，5280： | 1 |
| 19 | Curve Matching,Time Warping,and Light Fields:New Algorithms for Computing Similarity between Curves显示文摘 | Efrat A Fan Q | 2007 | J Math Imaging2007，27，： | 1 |
| 20 | The residual ovary syndrome:a 20-year experience显示文摘 | Dekel A Efrat Z Orvieto R | 1996 | Eur J Obstet Gyneeol Reprod Biol1996，68，12： | 1 |
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