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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Characterazation of plastein reaction products formed by pepsin, α-chymotrypsin, and papain treat- ment of egg albumin hydrolysates显示文摘 | Edwards J H Shipe W F | 1978 | Food Science1978，43，4： | 1 |
| 3 | Phylogenetic analysis: models and estimation prodedures 显示文摘 | CAVALLI-SFORZA L L EDWARDS A W F | 1967 | AmerJ HumGenet1967，19，： | 1 |
| 4 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 5 | A biomarker panel for peripheral arterial disease显示文摘 | Fung E T Wilson A M Zhang F Harris N Edwards K A Olin J W | 2008 | Vasc Med2008，13，： | 1 |
| 6 | Characterization of plastein reaction products formed by pepsin, α -chymotrypsin, and papain treatment of egg albumin hydrolysates显示文摘 | J H Edwards W F Shipe | 1978 | Journal of Food Science1978，43，： | 1 |
| 7 | Effect of dietary fat and cholesterol on the in vitro incorporation of acetate-14C into hen liver and ovarian lipids 显示文摘 | JOSEPH F W EDWARD C N RALPH M J | 1967 | The Journal of Nutrition1967，93，： | 1 |
| 8 | Community genomics among stratified microbial assemblages in the ocean's interior显示文摘 | DeLong E F Preston C M Mincer T Rich V Hallam S J Frigaard N U Martinez A Sullivan M B Edwards R Brito B R Chisholm S W Karl D M | | 0，，5760： | 1 |
| 9 | Small-Angle Neutron Scattering From a Polystyrene-b-Poly (methyl methacrylate) Diblock Copolymer in a Selective Solvent显示文摘 | Edwards C J C Richards R W Stepto R F T | 1986 | Polymer1986，27，5： | 1 |
| 10 | Isotope Dilution Mass Spectrometry and the National Reference System显示文摘 | George B John F Edward W | | 0，，12： | 1 |
| 11 | General motor's H13 material and heat treat specification 显示文摘 | Edward W F | 2000 | Die Casting Engineer2000，，56： | 1 |
| 12 | Treatment of carcinoma of the penis the case for primary lymphadenectomy显示文摘 | Mc Dougal W Kirschner F J EDwards R | 1986 | J Urol1986，136，： | 1 |
| 13 | Chloroplast and cytosolic glutamine synthetase are encoded by homologous nuclear genes which are differentially expressed in vivo 显示文摘 | TINGEY S V TSAI F Y EDWARDS J W | 1988 | Biol Chem1988，263，20： | 1 |
| 14 | The history of likelihood 显示文摘 | Edwards A W F | 1974 | International Statistical Review1974，42，1： | 1 |
| 15 | Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial显示文摘 | Edward J Gane Stuart K Roberts Catherine AM Stedman Peter W Angus Brett Ritchie Rob Elston David Ipe Peter N Morcos Linda Baher Isabel Najera Tom Chu Uri Lopatin M Michelle Berrey William Bradford Mark Laughlin Nancy S Shulman Patrick F Smith | 2010 | The Lancet2010，，9751： | 1 |
| 16 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia显示文摘 | Jeremy W Fox Edward D Lamperti Yaman Z Ek?io?lu Susan E Hong Yuanyi Feng Donna A Graham Ingrid E Scheffer William B Dobyns Betsy A Hirsch Rodney A Radtke Samuel F Berkovic Peter R Huttenlocher Christopher A Walsh | 1998 | Neuron1998，，6： | 1 |
| 17 | MALDI - TOF mass spectrometry: Obtaining reliable mass spectra for insoluble carbonaceous pitches显示文摘 | EDWARDS W F JIN L THIES M C | 2003 | Carbon2003，41，： | 1 |
| 18 | Spiders of Florida (USA) citrus groves显示文摘 | Mansour F Ross J W Edwards G B | 1982 | Florida Entomolo- gist1982，65，4： | 1 |
| 19 | Comparison of belowground biomass in natural deciduous forests and loblolly pine plantation 显示文摘 | Harris W F Kinerson R S Edwards N T | 1977 | Pedobiologia1977，17，： | 1 |
| 20 | Rapid sea-level fall and deep-ocean temperature change since the last interglacial period 显示文摘 | Cutler K B Edwards R L Yatlor F W | 2003 | Earth Planet Sei Lett2003，206，： | 1 |
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