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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 3 | A randomized controlled trial of exercise to improve outcomes of acute hospitalization in older adults显示文摘 | Siebens H Aronow H Edwards D | 2000 | J Am Geriatr Soc2000，48，12： | 1 |
| 4 | Physical performance in relation to external temperature显示文摘 | Dill D B Edwards H T Bauer P S | 1931 | Aebeitsphysiol1931，4，： | 1 |
| 5 | Timing, duration, and transitions of the last interglacial asian monsoon 显示文摘 | Yuan D X Cheng H Edwards R L | 2004 | Science2004，304，： | 1 |
| 6 | The application of a piezoelectric bar gauge to shock tube studies显示文摘 | Edwards D H Davies L Lawrence T R | 1964 | J Sci Instrum1964，64，： | 1 |
| 7 | The dener school-based adolescend hepatitis B vaccine program;A cost analysis with fist simulation显示文摘 | Robert R D Edward J H Rebecca S | 1997 | Am J Public Health1997，17，： | 1 |
| 8 | Timing,duration,and transitions of the last interglacial Asian monsoon显示文摘 | Yuan D X Cheng H Edwards R L | 2004 | Science2004，304，5670： | 1 |
| 9 | The diffraction of a planar detonation wave at an abrupt area change 显示文摘 | Edwards D H Thomas G O Nettleton M A | 1979 | Journal of Fluid Mechanics1979，95，： | 1 |
| 10 | Instabilities in Detonation Waves Near the Limits of Propagation 显示文摘 | Edwards D H Morgan J M | 1977 | Journal of Physics D: Applied Physics1977，10，17： | 1 |
| 11 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 12 | Shock Diffraction in Channels with 90° Bends 显示文摘 | Edwards D H Fearnley P Nettleton M A | 1983 | Fluid Mech1983，132，： | 1 |
| 13 | Formation of thermal decomposition cavities in physical vapor transport of silicon carbide 显示文摘 | EDWARD K S THOMAS K VOLKER D H | 2000 | Journal of Electronic Materials2000，29，3： | 1 |
| 14 | Timing duration and transitions of the last interglacial Asian monsoon显示文摘 | Cheng H Edwards R L | 2004 | Science2004，304，： | 1 |
| 15 | High performanceliquid chromatographic analysis of lactose-hydrolysed milk显示文摘 | INDYK H E EDWARDS M J WOOLLARDB D C | 1996 | FoodChemistry1996，57，4： | 1 |
| 16 | The Diffraction of Detonation Waves in Channels with 90° Bends 显示文摘 | Edwards D H Thomas G O | 1983 | Combustionis1983，3，1： | 1 |
| 17 | Cloning and characterisation of an oleosin gene from Brassica napus 显示文摘 | W Edwards C H Shaw D J Murphy | 1992 | Plant Molecular Biology1992，19，3： | 1 |
| 18 | Quantitative controls on submarine slope failure morphology显示文摘 | Lee H J Schwab W J and Edwards B D | 1991 | Marine Geotechnology1991，10，： | 1 |
| 19 | Two cytosolic glutamine synthetase isoforms of maize are specifically involved in the control of grain production 显示文摘 | Martin A Lee J Kichey T Gerentes D Zivy M Tatout C Dubois F Balliau T Valot B Davanture M Laforgue T T Quillere I Coque M Gallais A Moro M B G Bethencourt L Habash D Z Lea P J Charcosset A Perez P Murigneux A Sakakibara H Edwards K J Hirel B | 2006 | The Plant Cell2006，18，11： | 1 |
| 20 | Quality retention in strawberry and carrot purees dried with Refractance Window^TM System显示文摘 | ABONYI B l FENG H TANG J EDWARDS C G CHEW B P MATTINSON D S FELLMAN J K | 2001 | Jour- nal of Food Science2001，67，： | 1 |
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