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| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 2 | Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms显示文摘Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling(SAC)and flow diverters.Glycoprotein IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy(DAPT)are required to prevent thromboembolic complications afterwards.We sought to determine the safety of tirofiban and DAPT in these cases.Methods We conducted a retrospective analysis of our database for patients with intracranial aneurysms who underwent SAC or flow diversion.The tirofiban-DAPT protocol used is described.Data regarding duration of infusion,placement of external ventricular devices(EVDs),complications,haemoglobin levels and platelet count before and 24 hours after antiplatelet therapy were collected and analysed.results One-hundred and forty-one patients with 148 aneurysms/procedures were included.110 aneurysms were treated acutely and 38 electively.Minor and major haemorrhagic events were recognised in 20%(30/148)aneurysms.Only 5(3.4%)intracerebral haemorrhages were symptomatic:3 cortical/SAH and 2 EVD-related.The average blood volume in symptomatic haemorrhages was 24.8 cc versus 5.42 cc in asymptomatic haemorrhages(p=0.002).The rate of EVD-related haemorrhages was 15.7%(19/121)and only 2(1.7%)were symptomatic.Most haemorrhagic events occurred in ruptured aneurysms(90.1%,p=0.01).No significant change in platelet count or haemoglobin levels before and 24 hours after administration of tirofiban and DAPT was documented.Concomitant administration of heparin did not increase haemorrhagic events.Conclusion The use of the GP IIb/IIIa inhibitors tirofiban and DAPT in this series was safe.Tirofiban and DAPT did not affect platelet count or haemoglobin levels and did not increase rate of symptomatic haemorrhages or thromboembolic complications. | Edgar A Samaniego Emilee Gibson Daichi Nakagawa Santiago Ortega-Gutierrez Mario Zanaty Jorge A Roa Pascal Jabbour David M Hasan | 2019 | Stroke & Vascular Neurology2019，4，1： | 17 |
| 3 | Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis显示文摘background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain unknown.Methods We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral arteries.Stroke mechanism,collateral circulation,and degree and length of stenosis were analysed.The primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or death.Other outcome variables included modified Rankin Scale(mRS)score on discharge and last follow-up.results Of 6369 patients with AIS/TIA,91(1.43%)had ISBAS.Seventy-three(80.2%)patients presented with AIS and 18(19.8%)with TIA.Twenty-nine(31.9%)were women and the median age was 66.8±13.6 years.The mean follow-up time was 2.7 years.The most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-Meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral circulation.Approximately 13% of patients with ISBAS presented with complete BA occlusion.Conclusion ISBAS is an uncommon(1.43%)cause of TIA and AIS.Men in their 60s are mostly affected,and artery-to artery embolism is the most common stroke mechanism.Mid-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis. | Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa David M Hasan Colin Derdeyn Biyue Dai Harold Adams Enrique Leira | 2019 | Stroke & Vascular Neurology2019，4，4： | 10 |
| 4 | Progress in structural materials for aerospace systems 1 1 The Golden Jubilee Issue—Selected topics in Materials Science and Engineering: Past, Present and Future, edited by S. Suresh.显示文摘 | James C Williams Edgar A Starke | 2003 | Acta Materialia2003，，19： | 7 |
| 5 | Liver dysfunction and SARS-CoV-2 infection显示文摘Severe acute respiratory syndrome coronavirus 2 infection is the cause of coronavirus disease 2019(COVID-19),which predominantly affects the respiratory system;it also causes systemic and multi-organic disease.Liver damage is among the main extrapulmonary manifestations.COVID-19-associated liver injury is defined as any liver damage occurring during the disease course and treatment of COVID-19 in patients with or without pre-existing liver disease,and occurs in approximately one in five patients.Abnormal liver test results have been associated with a more severe course of COVID-19 and other complications,including death.Mechanisms linking COVID-19 to liver injury are diverse.Particular consideration should be made for patients with pre-existing liver disease,such as metabolic dysfunction-associated fatty liver disease,chronic liver disease due to viral or autoimmune disease,liver transplant carriers,or cirrhosis,given the risk for more severe outcomes.This manuscript summarizes the current lines of evidence on COVID-19-associated liver injury regarding pathophysiology,clinical significance,and management in both patients with or without preexisting liver disease,to facilitate clinicians’access to updated information and patient care.Finally,we mention the ideas and recommendations to be considered for future research. | Abraham Edgar Gracia-Ramos Joel Omar Jaquez-Quintana Raúl Contreras-Omaña Moises Auron | 2021 | World Journal of Gastroenterology2021，27，26： | 2 |
| 6 | Advances in cellulose ester performance and application显示文摘 | Kevin J Edgar Charles M Buchanan John S Debenham Paul A Rundquist Brian D Seiler Michael C Shelton Debra Tindall | 2001 | Progress in Polymer Science2001，，9： | 2 |
| 7 | Effect of Nd3+doping on structure,microstructure,lattice distortion and electronic properties of TiO_2 nanoparticles显示文摘Doped and undoped TiCh nanoparticles were prepared by Stober method and thermally treated at 600 ℃.The effect of Nd^(3+) ion on the structure and micro structure of anatase-phase TiCh nanocrystals was studied by Rietveld refinement method using X-ray powder diffraction data.Bond lengths,bond angles,and edges distances were analyzed.The phase formation was confirmed by high-resolution transmission electron microscopy.The adjustment of Ti-0 bond length induced by the addition of Nd^(3+) ions,reduced the octahedral distortion and altered the octahedral array in the anatase-phase TiCh nanocrystal.The changes of structure and microstructure were mainly observed for TiCh nanoparticles doped with 0.1 at.%of Nd^(3+) ions and attributed to the cationic substitution of Ti^(4+) ions which promoted changes in the density of states and gap band of TiCh.The dopant insertion resulted in a better structural stability of the nanocrystals that enhanced their charge transference and photocatalytic efficiency. | Balter Trujillo-Navarrete María del Pilar Haro-Vázquez Rosa María Félix-Navarro Francisco Paraguay-Delgado Henry Alvarez-Huerta Sergio Pérez-Sicairos Edgar Alonso Reynoso-Soto | 2017 | Journal of Rare Earths2017，35，3： | 2 |
| 8 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 9 | Progress in structural materials for aerospace systems 显示文摘 | James C W Edgar A S | 2003 | Acta Materialia2003，51，： | 1 |
| 10 | The catalysis of biodiesel synthesis显示文摘 | Lotero Edgar Goodwin James G Bruce David A | 2006 | Catalysis2006，19，： | 1 |
| 11 | Surface modification to improve dyeing of cotton fabric with a cationic dye显示文摘 | PISUNTORNSUG C YANUMET N EDGAR A O | 2002 | Coloration Technology2002，118，2： | 1 |
| 12 | Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: Impli?cations for treatment and surgical management显示文摘 | EmamaulleeJ A Edgar R Toso C | 2010 | Liver Transpl2010，16，2： | 1 |
| 13 | The cataysis of biodiesel synthesis显示文摘 | Lotero Edgar Goodwin James G Bruce David A | 2006 | Catalysis2006，19，： | 1 |
| 14 | The gene structure and expression of human ABHD1 :overlapping polyadenylation signal sequence with Sec12显示文摘 | Edgar A J | 2003 | BMC Genomics2003，，4： | 1 |
| 15 | Diatom Locomotion: A Consideration of Movement in Highly Viscous Situation显示文摘 | EDGAR L A | 1982 | British PhyoAlogioal Journal1982，17，3： | 1 |
| 16 | Temperature dependence of Faraday rotation and magnetic susceptibility for Ce 3+ and Pr 3+ ions in fluorozirconate glass显示文摘 | A Edgar D Giltrap D.R MacFarlane | 1998 | Journal of Non-Crystalline Solids1998，，3： | 1 |
| 17 | Implications of experimental petrology to the evolution of ultrapotassic rocks显示文摘 | Edgar A D and Vukadinovic D | 1992 | Lithos1992，28，： | 1 |
| 18 | Male seem organ chemicals of the vine moth, Phalaenoides glycinae Lew (Agaristidae) 显示文摘 | EDGAR J A COCKRUM P A CARRODUS B B | 1979 | Expefientia1979，35，： | 1 |
| 19 | Run-to-run control and performance monitoring of overlay in semiconductor manufacturing 显示文摘 | BODE C A KO B S EDGAR T F | 2004 | Control Engineering Practice2004，12，7： | 1 |
| 20 | Intestinal stem cells in the adult Drosophilamidgut显示文摘 | Jiang H Edgar B A | 2011 | Exp Cell Res2011，317，19： | 1 |
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