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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 3 | Laser capture microdisaection for analysis of macrophage gene expression from athernsclerotic lesions 显示文摘 | Trogan E Fisher EA | 2005 | Methods Mol Biol2005，293，： | 1 |
| 4 | Dietary fiber and distal colorectal adenoma in men 显示文摘 | Platz EA Giovannucci E Rimm EB | 1997 | Cancer Epidemiol Biomarkers Prey1997，6，9： | 1 |
| 5 | Characterization of the new immunosuppressive drug undecylprodigiosin in human lymphocytes显示文摘 | Mortellaro A Taverna S Fornasiero C Scheiber EA Erba E Colotta F | 1997 | J Immunol1997，158，8： | 1 |
| 6 | New guidelines to evaluate the response to treatment insolid tumors显示文摘 | Therasse P A rbu ck SG E isenhauer EA | 2000 | J Natl Cancer Inst2000，92，3： | 1 |
| 7 | The Canadian study of the sirolimus-eluting stent in the treatment of patients with long de novo lesions in small native coronary arteries (C-SIRIUS)显示文摘 | Schampaert E Cohen EA Schluter M | 2004 | J Am Coil Cardiol2004，43，： | 1 |
| 8 | Role of nitric oxide in experimental obliterative bronchiolitis( chronic rejection) in the rat显示文摘 | Kallio EA Koskinen PK Aanik E | 1997 | Jclin inveat1997，100，12： | 1 |
| 9 | Mitochondrial DNA mutations and pathogenesis 显示文摘 | Schon EA Bonilla E DiMauro S | 1997 | J Bioenerg Biomembr1997，29，： | 1 |
| 10 | Effects of different retraction medicaments on gingival tissue显示文摘 | Akca EA Yildirim E Dalkiz M | 2006 | Quintessence lnt2006，37，1： | 1 |
| 11 | Upregula-tion of PD-1 expression on HIV-specific CD8 T cells leads to reversible immune dysfunction 显示文摘 | Trautmann L Janbazian L Chomont N Said EA Gimmig S Bessette B Boulassel MR Delwart E Sepulveda H Balderas RS Routy JP Haddad EK Sekaly RP | 2006 | Nat Med2006，12，10： | 1 |
| 12 | The role of acute and early HIV infection in the spread of HIV and implications for transmission prevention strategies in Lilongwe, Malawi: a modelling study显示文摘 | Kimberly A Powers Azra C Ghani William C Miller Irving F Hoffman Audrey E Pettifor Gift Kamanga Francis EA Martinson Myron S Cohen | 2011 | The Lancet . 2011 (9787)2011，，： | 1 |
| 13 | Early detection of anastomotic leakage after elective low anterior resection 显示文摘 | Fouda E Nakeeb EA Magdy A | 2011 | J Gastrointest Surg2011，15，1： | 1 |
| 14 | Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints显示文摘 | Levesque AA Kohn EA Bresnick E | 2005 | Oncogene2005，24，23： | 1 |
| 15 | Clinicopathologic speetnun of massive and submassive hepatic necrosis in infants and children显示文摘 | Kitsch R Yap J Roberts EA Cutz E | 2009 | Human Pathol2009，40，4： | 1 |
| 16 | Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyrurvate diox- ygenase 显示文摘 | Lindstedt S Holme E Lock EA | 1992 | Lancet1992，340，8823： | 1 |
| 17 | Tumor entrained neutrophils inhibit seeding in the premetastatic lung显示文摘 | GRANOT Z HENKE E COMEN EA | 2011 | Cancer Cell2011，20，3： | 1 |
| 18 | Leptin-replacement therapy for lipodystrophy显示文摘 | Oral EA Simha V Ruiz E | 2002 | N Engl J Med2002，346，8： | 1 |
| 19 | The epigenome view:an effort towards non-invasive prenatal diagnosis 显示文摘 | Papageorgiou EA Koumbaris G Kypri E | 2014 | Genes (Basel)2014，5，2： | 1 |
| 20 | BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1显示文摘 | Majumdar MK Wang E Morris EA | 2001 | J Cell Physiol2001，189，3： | 1 |
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