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| 1 | Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease:An observation on non-absorbable antibiotics显示文摘AIM: To estimate the prevalence of small intestine bacterial overgrowth (SIBO) among patients with an earlier diagnosis of irritable bowel disease (IBS) in our geographical area, and to collect information on the use of locally acting non-absorbable antibiotics in the management of SIBO. METHODS: A non-interventional study was conducted in 73 consecutive patients with a symptom-based diagnosis.. RESULTS: When the patients underwent a 'breath test', 33 (45.2%) showed the presence of a SIBO. After treatment with rifaximin 1200 mg/d for seven days in 32 patients, 19 (59.4%) showed a negative 'breath test' one week later as well as a significant reduction of symptoms, thus confirming the relationship between SIBO and many of the symptoms claimed by patients. In the other 13 patients, 'breath test' remained positive, and a further cycle of treatment with ciprofloxacin 500 mg/d was given for 7 additional days, resulting in a negative 'breath test' in one patient only. CONCLUSION: (1) about half of the patients with a symptomatic diagnosis of IBS have actually SIBO, which is responsible for most of the symptoms attributed to IBS; (2) only a 'breath test' with lactulose (or with glucose in subjects with an intolerance to lactose) can provide a differential diagnosis between IBS and SIBO, with almost identical symptoms; and (3) the use of non-absorbable antibiotics may be useful to reduce the degree of SIBO and related symptoms; it must be accompanied, however, by the correction of the wrong alimentary habits underlying SIBO. | I Esposito A de Leone G Di Gregorio S Giaquinto L de Magistris A Ferrieri G Riegler | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | Pathology of pancreatic ductal adenocarcinoma:Facts,challenges and future developments显示文摘Despite major improvements concerning its diagnosis and treatment,pancreatic ductal adenocarcinoma(PDAC) remains an aggressive disease with an extremely poor prognosis. Pathology,as interface discipline between basic and clinical medicine,has substantially contributed to the recent developments and has laid the basis for further progress. The definition and classification of precursor lesions of PDAC and their molecular characterization is a fundamental step for the potential identification of biomarkers and the development of imaging methods for early detection. In addition,by integrating findings in humans with the knowledge acquired through the investigation of transgenic mouse models for PDAC,a new model for pancreatic carcinogenesis has been proposed and partially validated in individuals with genetic predisposition for PDAC. The introduction and validation of a standardized system for pathology reporting based on the axial slicing technique has shown that most pancreatic cancer resections are R1 resections and that this is due to inherent anatomical and biological properties of PDAC.This standardized assessment of prognostic relevant parameters represents the basis for the successful conduction of multicentric studies and for the interpretation of their results.Finally,recent studies have shown that distinct molecular subtypes of PDAC exist and are associated with different prognosis and therapy response.The prospective validation of these results and the integration of molecular analyses in a comprehensive pathology report in the context of individualised cancer therapy represent a major challenge for the future. | Irene Esposito Bj?rn Konukiewitz Anna Melissa Schlitter Günter Kl?ppel | 2014 | World Journal of Gastroenterology2014，20，38： | 5 |
| 3 | Update on surgical treatment of pancreatic neuroendocrine neoplasms显示文摘Pancreatic neuroendocrine neoplasms(PNENs) are rare and account for only 2%-4% of all pancreatic neoplasms. All PNENs are potential(neurendocrine tumors PNETs) or overt(neuroendocrine carcinomas PNECs) malignant,but a subset of PNETs is low-risk. Even in case of low-risk PNETs surgical resection is frequently required to treat hormone-related symptoms and to obtain an appropriate pathological diagnosis. Low-risk PNETs in the body and the tail are ideal for minimallyinvasive approaches which should be tailored to the individual patient. Generally,surgeons must aim for parenchyma sparing in these cases. In high-risk and malignant PNENs,indications for tumor resection are much wider than for pancreatic adenocarcinoma,in many cases due to the relatively benign tumor biology. Thus,patients with locally advanced and metastatic PNETs may benefit from extensive resection. In experienced hands,even multi-organ resections are accomplished with acceptable perioperative morbidity and mortality rates and are associated with excellent long term survival. However,poorly differentiated neoplasms with high proliferation rates are associated with a dismal prognosis and may frequently only be treated with chemotherapy. The evidence on surgical treatment of PNENs stems from reviews of mostly singlecenter series and some analyses of nation-wide tumor registries. No randomized trial has been performed to compare surgical and non-surgical therapies in potentially resectable PNEN. Though such a trial would principally be desirable,ethical considerations and the heterogeneity of PNENs preclude realization of such a study. In the current review,we summarize recent advances in the surgical treatment of PNENs. | Jan G D’Haese Chiara Tosolini Güralp O Ceyhan Bo Kong Irene Esposito Christoph W Michalski J?rg Kleeff | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 4 | Antioxidant activity and dietary fiber in durum wheat bran by-products显示文摘 | ESPOSITO F ARLOTTI G BONIFATI A M | 2005 | Food Research International2005，38，： | 1 |
| 5 | American Association for the Surgery of Trauma Organ Injury Scale I:Spleen,Liver, and Kidney,Validation Based on the Nation- al trauma Data Bank 显示文摘 | Tinkoff G Esposito TJ Reed J | 2008 | J Am Coil Surg2008，207，： | 1 |
| 6 | Bioconversion ofapple pomace into a nutritionally enriched substrate by Candida utilis andPleurotus ostreatus显示文摘 | VILLAS-BOAS S G ESPOSITO E MENDONCA M M | 2003 | World Journal of Microbiology&Biotechnology2003，19，： | 1 |
| 7 | Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency显示文摘 | VOS M ESPOSITO G EDIRISINGHE J N | 2012 | Science2012，336，6086： | 1 |
| 8 | Reaction between methanol and commercial seed oils under microwave irradiation 显示文摘 | Breccia A Esposito B Fratadocchi G B | 1999 | Journal of Microwave Power and Electromagnetic Energy1999，34，1： | 1 |
| 9 | Laparoscopic management of ovar- ian cysts in newborns 显示文摘 | Esposito C Garipoli V Di Matteo G | 1998 | Surg Endosc1998，12，9： | 1 |
| 10 | Antioxidant activity and dietary fiber in durum wheat br-an byproducts显示文摘 | Esposito F Arlottib G Bonifati A M | 2005 | Food Research International2005，38，： | 1 |
| 11 | On the positional and chain specificities of Candida cylindracea 显示文摘 | Benzonana G Esposito S | 1971 | Biochim Biophys Acta1971，231，： | 1 |
| 12 | A search for type 1 diabetes susceptibility genes in families from the united kingdom显示文摘 | MEIN C A ESPOSITO L DUNN M G | 1998 | Nat Genet1998，19，： | 1 |
| 13 | Genomie and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury显示文摘 | Esposito G hnitola J Lu J | 2008 | Hum Mol Genet2008，17，3： | 1 |
| 14 | Laparoscopic orchio- pexy without division of the spermatic vessels : can it be con- sidered the procedure of choice in cases of intraabdominal testis 显示文摘 | Esposito C Vallone G Settimi A | 2000 | Surg Endosc2000，，14： | 1 |
| 15 | Primary and secondary prevention of atherosclerosis:is there a role for antiox-idants显示文摘 | Paolisso G Esposito R D′Alessio MA Barbieri M | | 0，，04： | 1 |
| 16 | Cosci versus Summers tech- nique for crestal sinus lift:3-year results from a randomised con- trolled trial显示文摘 | Esposito M Cannizzaro G Barausse C | 2014 | Eur J Oral Implantol2014，7，2： | 1 |
| 17 | Role of melatonin supplementation in neurodegenerative disorders显示文摘 | POLIMENI G ESPOSITO E BEVELACQUA V | 2014 | Front Bio Sci ( Landmark Ed)2014，19，1： | 1 |
| 18 | Lipoprotein metabolism during normal pregnancy显示文摘 | Brizzi P Tonolo G Esposito F | 1999 | Am J Obstet Gynecol1999，181，2： | 1 |
| 19 | Heparin-binding hemaggluti-nin HBHA from Mycobacterium tuberculosis affects actin polymeris- ation显示文摘 | Esposito C Marasco D Delogu G | 2011 | Bioehem Biophys Res Commun2011，410，2： | 1 |
| 20 | C02 laser surgery in the treatment of glottic cancer显示文摘 | Mota G Esposito E Motta S | 2005 | Head Neck2005，27，7： | 1 |
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