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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges 显示文摘 | Mine 0 1 Erdal C Ahmet A | 2006 | Int J Pharmaceut2006，318，： | 1 |
| 3 | The competition between PAOs ( phosphorus accumulating organisms) and GAOs (glycogen accumulating organisms) in EBPR (enhanced biological phosphorus removal) systems at different temperatures and the effects on system performance 显示文摘 | ERDAL U G ERDAL Z K RANDALL C W | 2003 | Water Sci Technol2003，47，11： | 1 |
| 4 | Preparation and characterization of Al203-TiO2 powders by chemical synthesis for plasma spraycoatings显示文摘 | Erdal C | 2002 | Journal of Materials Processing Technology2002，128，： | 1 |
| 5 | Wireless sensor networks:a survey显示文摘 | IF A WEILIAN S YOGESH S ERDAL C | 2002 | Computer Networks2002，38，4： | 1 |
| 6 | Serotonin transporter gene olymorphism in irritable bowel syndrome显示文摘 | PATA C ERDAL M E DERICI E | 2002 | Am J Gastroenterol2002，97，： | 1 |
| 7 | The competition betwecn PAOs (phosphorus accumulating organisms) and GAOs(glycogen accumulating organisms) in EBPR (enhanced biological phosphorus removal) systems at different temperatures and the effects on system performance显示文摘 | Erdal U G Erdal Z K Randall C W | 2003 | Water Sci Technol2003，47，： | 1 |
| 8 | diltiazem provides higher internal mammary artery flow than nitroglycerin during coronary artery bypass grafting 显示文摘 | Tabel Y Erdal C | 2004 | European Journal of Cardiothoracic Surgery2004，25，： | 1 |
| 9 | Serotonin transporter gene polymorphism in irritable bowel syndrome显示文摘 | PATA C ERDAL M E DERICI E | 2002 | Am J Gastroenterology2002，97，： | 1 |
| 10 | Association of the - 1438G/A and 102T/C polymorphism of the 5-Ht2A receptor gene with irritable bowel syndrome 5-Ht2A gene polymorphism in irri- table bowel syndrome 显示文摘 | Pata C Erdal E Yazc K | 2004 | J Clin Gastroenterol2004，38，7： | 1 |
| 11 | The competition between PAOs (phosphorus accumulating organisms) and GAOs (glycogen accumulating organisms) in EBPR (enhanced biological phosphorus removal) systems at different temperatures and the effects on system performance显示文摘 | Erdal U G Erdal Z K Randall C W | 2003 | Wat Sci & Tech2003，47，11： | 1 |
| 12 | Biochemistry of enhanced biological phosphorus removal and anaerobic COD stabilization显示文摘 | Erdal Z K Erdal U G Randall C W | 2005 | Water Sci & Tech2005，52，1011： | 1 |
| 13 | Association of the-1438 G/A and 102 T/C polymorphism of the 5-Ht2A receptor gene with irritable bowel syndrome 5-Ht2A gene polymorphism in irritable bowel syndrome 显示文摘 | Pata C Erdal E Yazc K | 2004 | J Clin Gastroenterol2004，38，7： | 1 |
| 14 | Serotonin transporter gene polymorphism in irritable bowel syndrome 显示文摘 | Pata C Erdal ME Deriei E | 2002 | Am J Gastroenterol2002，97，7： | 1 |
| 15 | The competition between PAOs (phosphorus accumulating organisms) and GAOs (glycogen accu- mulating organisms) in EBPR (enhanced biological phosphorus removal) systems at different temperatures and the effects on system performance显示文摘 | Erdal U G Erdal Z K Randal C W | 2003 | International Water Association2003，47，11： | 1 |
| 16 | Asuivey on Routing Protocols for Wireless Sensor Networks显示文摘 | Ian F Akyildiz Weilian S Yogesh S Erdal C | 2004 | IEEE Communications Magazine2004，40，8： | 1 |
| 17 | Effect on residual stresses in plasmasprayed A1-Si/B4C composite coatings subjected to thermal shock 显示文摘 | Ozkan S Erdal C Cem O | 2005 | Surface and Coatings Technology2005，200，7： | 1 |
| 18 | Serotonin transporter gene polymorphism in irritable bowel syndrome 显示文摘 | Pata C Erdal ME Derici E | 2002 | Am J Gastroenterol2002，97，7： | 1 |
| 19 | Comparison of different dose regimens of enoxaparin in deep vein thrombosis therapy in pregnancy显示文摘 | Cüneyt Narin Hasan Reyhanoglu Baykal Tülek Rasit Onoglu Erdal Ege Ali Sarigül Mehmet Yeniterzi Isa Durmaz | 2008 | Advances in Therapy2008，，6： | 1 |
| 20 | Serum leptin, atherogenic lipids and glucose levels in patients with skin tags显示文摘 | Gorpelioglu C Erdal E Ardicoglu Y | 2009 | Indian J Dermatol2009，54，1： | 1 |
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