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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Who blogs? Personality predictors of bIogging 显示文摘 | Guadagno R E Okdie B M Eno C A | 2008 | Computers in Human Behavior2008，，24： | 1 |
| 3 | Clinicopathological study of intrapelvie cancer spread to the ilica area in lower rectal adenocarcinoma by serial sectioning显示文摘 | Eno H Yamaauchi C Hase K | 1999 | Br J Surg1999，86，： | 1 |
| 4 | Activation of the proapoptotic Bcl -2 protein Bax by a small molecule induces tumor cell apopto- sis显示文摘 | ZHAO G ZHU Y ENO C O | 2014 | Mol Cell Biol2014，34，7： | 1 |
| 5 | Rosin and rosin derivatives显示文摘 | Enos H I Harris G C tledrick G W | 1968 | Encyclopedia of chemical technology1968，17，： | 1 |
| 6 | Drug Identification through analysis of maggots 显示文摘 | Beyer J C Enos W F Stajie M | 1980 | Journal of Forensic Sciences1980，25，2： | 1 |
| 7 | Computational study of conjugate heat transfer in T-junctions显示文摘 | KUHN S BRAILLARD O NI(C)ENO B | 2010 | Nuclear Engineering and Design2010，240，6： | 1 |
| 8 | Estimation of sensitivity and specificity of diagnostic tests and disease prevalence when the true disease state is unknown显示文摘 | ENOE C GEORGIADIS MP JOHNSON WO | 2000 | Prev Vet Med2000，45，12： | 1 |
| 9 | Postweaning multisystemic wasting syndrome in Danish pig herds:productivity,clinical signs and pathology显示文摘 | NIELSEN E O ENOE C JORSAL S E | 2008 | Vet Rec2008，162，31： | 1 |
| 10 | Estimating the sensitivity and specificity of diagnostic tests and disease prevalence when the true disease state is unknown 显示文摘 | Enoe C Georgiadis M P Johnson W O | 2000 | Prev Vet Med2000，，45： | 1 |
| 11 | Expression profiling of renal epithelial neoplasms:a method for tumor classification and discovery of diagnostic molecular markers显示文摘 | YOUNGAN AMINM B MOP ENO C S | 2001 | American Journal of Pathology2001，158，5： | 1 |
| 12 | Who blogs? Per- sonality predictors of blogging 显示文摘 | GUADAGNO R E OKDIE B M ENO C A | 2008 | Computers in Human Be- havior2008，24，5： | 1 |
| 13 | Caveolae biochemical analysis显示文摘 | Chatenay-Rivauday C Cakar ZP J eno P | 2004 | Mol boil Rep2004，31，： | 1 |
| 14 | Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis显示文摘 | Zhao G Zhu Y Eno C O | 2014 | Mol Cell Biol2014，34，7： | 1 |
| 15 | Who blogs? Personality predictors of blogging 显示文摘 | GUADAGNO R E OKDIE B M ENO C A | 2008 | Computers in Hu- man Behavior2008，24，： | 1 |
| 16 | Who blogs? Person- ality predictors ofblogging显示文摘 | Guadagno Ik E Okdie B M Eno C A | 2008 | Computers in Human Behav- ior2008，24，5： | 1 |
| 17 | The prevalence of pneumonia, pleuri- tis, pericarditis and liver spots in Danish slaughter pigs in 1998, including comparison with 1994 显示文摘 | Christensen G Enoe C | 1999 | Danish Vet J1999，82，： | 1 |
| 18 | Effect of temperature on the free radical scavenging capacity of extracts from red and white grape pomace peels 显示文摘 | LARRAURI J A SANCHEZ - MOR ENO C SAURA - CALIXTO F | 1998 | Agric Food Chem1998，46，7： | 1 |
| 19 | Infectious and rea- ring-system related risk factors for chronic pleuritis in slaugh- ter pigs显示文摘 | Enoe C Mousing J Schirmer A L | 2002 | Prey Vet Med2002，54，4： | 1 |
| 20 | Ambient levels of UV-B in Hawaii combined with nutrient deficiency decrease photosynthesis in near-isogenic maize lines varying in leaf flavonoids:Flavonoids deerease photoinhibition in plants exposed to UV-B显示文摘 | LAUT S L ENO G GOLDSTEIN G SMITH C CHRISTOPHER D A | 2006 | Photosynthetica2006，44，3： | 1 |
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