|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evaluation of the hepatoprotective and antioxidant effects of Tegillarca granosa flesh body extract against potassium bromide toxicity via targeting the histomorphometry,chromosomal and expressions of TGF-β1,VEGF and COX-2 genes in rats显示文摘The hepatotoxic effect of potassium bromide(KBr)on rat liver tissues were determined,as well as the potential protective effect of Tegillaraca granosa(T.granosa)flesh body extract.Twenty adult male albino rats were equally distributed into four groups;Group(I)treated with physiological saline(control group),Group(II)was orally gavaged by 200 mg/kg of T.granosa body extract day after day,Group(III)was intoxicated by KBr(150 mg/kg bwt day after day orally)and finally,Group(IV)was given a combination of T.granosa flesh body extract plus KBr with similar doses in the second and third groups.At the end of one month,blood,liver tissue and bone marrow samples were collected to be used for the required laboratory examinations.In response to KBr toxicity,there was a significant increase in serum antioxidant biomarkers,which was accompanied by a significant change in hepatocyte ultrastructure and a significant change in carbohydrate and protein levels within the liver organ.In addition,KBr intoxication resulted in a substantial increase in the incidence of chromosomal aberrations such as holes,splits,deletions,fragments,ploidy,and ring chromosomes,as well as significant upregulation of TGF-1,VEGF,and COX-2 gene expression.The hepatotoxic effect of KBr was counteracted by treatment with T.granosa flesh body extract.T.granosa flesh body extract has a curative antioxidant and numerous protective effects against KBr hepatotoxicity. | ALI H.ABU ALMAATY BASMA M.HENDAM FAYEZ ALTHOBAITI EMAN FAYAD YASMIN M.ABD EL-AZIZ | 2022 | BIOCELL2022，46，1： | 1 |
| 2 | Investigation of the antioxidant defensive role of both AD-MSCs and BM-MSCs in modulating the alteration in the oxidative stress status in various STZ-diabetic rats’tissues显示文摘Diabetes mellitus(DM)could negatively affect patients’health via inducing a lot of serious functional hazards in many tissues’cells at molecular levels.Recently,many scientists had proposed stem cell therapy being an appropriate alternative treatment protocol for numerous health threatening issues including diabetes.Therefore,the current study was designed to investigate the antioxidant potentiality of two MSCs types in alleviating tissues’oxidative stress dramatic elevation resulting as a consequence of Type 1 DM induction.In our 4 weeks study,animals were divided into four groups:control group,STZ-diabetic group(D),D+AD-MSCs group and D+BM-MSCs group.Data reported that diabetic rats treated with either AD-MSCs or BM-MSCs exhibited a marvelous body tissues(Pancreas,Liver and Kidney)enhancing capabilities in attenuating the oxidative stress status;as evidenced by XO,ROS,and MDA levels down-regulation;with a general concomitant elevation in the antioxidants’content;evidenced by many enzymatic and non-enzymatic antioxidants up-regulation;relative to the diabetic untreated group.Interestingly,comparing both treatments with each other and to control group,most of the measured parameters were reverted back to near normal levels after AD-MSCs injection;which clearly point out their stunning health benefits and superiority as anti-diabetic agent in overcoming different tissues’complications;owing to their marked cytoprotective and regenerative potentialities. | SHADY G.EL-SAWAH FAYEZ ALTHOBAITI ADIL ALDHAHRANI EMAN FAYAD MARWA A.ABDEL-DAYEM REHAB M.AMEN EL SHAIMAA SHABANA EHAB I.EL-HALLOUS HANAN M.RASHWAN | 2021 | BIOCELL2021，45，6： | 0 |
| 3 | Anti-inflammatory and antioxidant potential capacities of AD-MSCs and BM-MSCs in suppressing pancreaticβ-cells auto-immunity and apoptosis in rats with T1DM induced model显示文摘Since Type 1 diabetes(T1DM)occurs whenβ-cells mass is reduced to less than 20%of the normal level due to autoimmune destruction of cells resulting in the inability to secrete insulin,preservation or replenishment of the functionalβ-cells mass has become a major therapeutic focus for this diabetic type treatment.Thus,this 4-week work plan was designed to determine which mesenchymal stem cells(MSCs)type is more appropriate to alleviate pancreatic hazards resulting from diabetes induction;via tracking a comparative study between MSCs derived from adipose tissue(AD-MSCs)and from bone marrow(BM-MSCs)in management of T1DM considering their immunomodulatory,anti-apoptotic and antioxidative roles.Rats were divided randomly into 4 groups;control,STZdiabetic(D),D+AD-MSCs,and D+BM-MSCs groups.Both stem cells types in this study were allogenic.Herein,both oxidative stress and antioxidant markers were evaluated using colorimetric analysis,while inflammatory,immune and apoptotic markers were assessed through flow cytometric analysis.Results showed that diabetic rats treated with either AD-MSCs or BM-MSCs exhibited marked pancreatic antioxidant and anti-inflammatory activities that were able to initiate pancreatic immunomodulation and reducingβ-cells apoptotic death,thus,help to restore their normal insulin secretion and hypoglycemic abilities.However,AD-MSCs injection was shown to be superior as a pancreatic regenerative tool in overcoming diabetes;owing to their marked antioxidant,anti-inflammatory,immunomodulatory,and anti-apoptotic characteristics over BM-MSCs treatment. | SHADY G.EL-SAWAH FAYEZ ALTHOBAITI HANAN M.RASHWAN ADIL ALDHAHRANI MARWA A.ABDEL-DAYEM EMAN FAYAD REHAB M.AMEN EL SHAIMAA SHABANA EHAB I.EL-HALLOUS | 2022 | BIOCELL2022，46，3： | 0 |
| 4 | The potency of N,N′-diphenyl-1,4-phenylenediamine and adiposederived stem cell co-administration in alleviating hepatorenal dysfunction complications associated with type 1 diabetes mellitus in rats显示文摘Background:The increasing occurrence of diabetes mellitus(DM)noted worldwide has considerably elicited concern in the recent past.DM is associated with elevated vascular complications,morbidity,mortality,and poor quality of life.In this context,mesenchymal stem cells(MSCs)have shown significant therapeutic potentialities in managing and curing type 1 DM owing to their self-renewable,immunosuppressive,and differentiation capacities.We investigated the potential action of N,N′-diphenyl-1,4-phenylenediamine(DPPD),a well-known synthetic antioxidant to enhance the therapeutic ability of the adipose-derived stem cells(AD-MSCs)in alleviating kidney and liver complications in diabetic rats.Methods:Over the four weeks of experiments,albino male rats(n=36)were split into six test groups:control,DPPD(250 mg/kg,i.p.),STZ-diabetic(D),D+DPPD,D+AD-MSCs(1×10^(6)cell/rat,i.v.),and D+AD-MSCs+DPPD treated groups.Results:Significant declines in the renal and hepatic oxidative stress markers(MDA,ROS,and AGEs)were observed coupled with a significant elevation in many antioxidant marker levels(GSH,SOD,CAT,GPx,HO-1,and TAC)in the diabetic rats treated with either DPPD or AD-MSCs or their co-administered injection compared to the diabetic untreated rats.This was suggested to be the leading cause of amelioration of the kidney functions(as measured by urea,uric acid,and creatine levels)and liver functions(as evidenced by the levels of AST,ALT,ALP,bilirubin,total proteins,albumin,and globulins).Conclusion:DPPD and AD-MSCs co-administration showed superior results in terms of the enhancement of the relative hepato-renal function,indicating the beneficial role of DPPD supplementation in increasing the therapeutic potential of AD-MSCs. | HANY M.ABD EL-LATEEF SAFA H.QAHL EMAN FAYAD SARAH A.ALTALHI IBRAHIM JAFRI EL SHAIMAA SHABANA MARWA K.DARWISH REHAB MAHER SAAD SHAABAN SHADY G.EL-SAWAH | 2023 | BIOCELL2023，47，8： | 0 |
| 5 | Vital Parameters Assessments of Starvation Tolerance of in vitro Populus alba Culture显示文摘Populus alba is a large woody deciduous plant.The plant has been introduced to shooting,then multiplication of rooting on Murashige and Skoog(MS)medium.This work was designed to estimate the effect of two factors(low levels of 1-Naphthaleneacetic acid NAA and sucrose)on P.alba response resulting in 6 treatments compared to the control,with twelve measured responses.There was a significant difference in some measurements in morphology,like plantlets fresh-weight,shoot-,root-length,and leaf number.In the physiological measurements,there were significant differences in all the measured parameters.The low concentrations of sucrose and media composition/power(MS grams/L)led to starvation in plants;however,these conditions led to enhancement in some morphological and physiological parameters to overcome the starvation effect,compared to the control.The RAPD-PCR molecular marker(four decamers)was used to evaluate the new individuals’genetic variation(instability),resulting in a total polymorphism percentage of 50.83%.It was formerly known that the plantlets were identical to each other and to the mother plant.In this study,however,the use of distinct media power,hormonal and sucrose levels resulted in molecular variation reflected in P.alba’s morphological and physiological responses. | Mohamed Fathy Ahmed Eman Zakaria Ahmed Salman Aloufi Mohammed Alqurashi Amal Alyamani Eman Fayad Eman Tawfik Hussien | 2022 | Phyton-International Journal of Experimental Botany2022，91，4： | 0 |
| 6 | Ameliorative effects of melatonin and zinc oxide nanoparticles treatment against adverse effects of busulfan induced infertility in male albino mice显示文摘Testicular damage is one of the most hazardous effects as it’s associated with azoospermia.Busulfan(Bu)is a highly toxic chemotherapeutic drug that affects testis.Thirty male Swiss albino mice divided into six groups of 5 animals each.Control(oral 0.9%saline daily for 75 days);Mel(20 mg/kg/day orally for 30 days);ZnO NPs(5 mg/kg/day i.p.for 30 days);BU(single i.p.injection of 40 mg/kg and then left for 45 days);BU+Mel(single 40 mg/kg dose of BU and left for 45 days followed by 20 mg/kg/day Mel for 30 days);BU+ZnO NPs(single dose of 40 mg/kg of BU and left for 45 days,then 5 mg/kg/day ZnO NPs for 30 days).Preparation and Characterization of ZnO NPs.Specimens from testis prepared for ultrastructural investigations using TEM after Masson’s trichrome and toluidine blue staining.BU induced histological and ultrastructural damage of the testis.Moreover,the present results could be concluded that Mel or ZnO NPs can protect the testicular tissue against ultrastructural alterations induced by BU by its antioxidant and anti-apoptotic effects. | AMOURA M.ABOU-EL-NAGA SHAKER A.MOUSA FAYEZ ALTHOBAITI EMAN FAYAD ENGY S.FAHIM | 2022 | BIOCELL2022，46，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员