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| 1 | Neurohumoral,cardiac and inflammatory markers in the evaluation of heart failure severity and progression显示文摘Heart failure is common in adult population,accounting for substantial morbidity and mortality worldwide.The main risk factors for heart failure are coronary artery disease,hypertension,obesity,diabetes mellitus,chronic pulmonary diseases,family history of cardiovascular diseases,cardiotoxic therapy.The main factor associated with poor outcome of these patients is constant progression of heart failure.In the current review we present evidence on the role of established and candidate neurohumoral biomarkers for heart failure progression management and diagnostics.A growing number of biomarkers have been proposed as potentially useful in heart failure patients,but not one of them still resembles the characteristics of the'ideal biomarker.'A single marker will hardly perform well for screening,diagnostic,prognostic,and therapeutic management purposes.Moreover,the pathophysiological and clinical significance of biomarkers may depend on the presentation,stage,and severity of the disease.The authors cover main classification of heart failure phenotypes,based on the measurement of left ventricular ejection fraction,including heart failure with preserved ejection fraction,heart failure with reduced ejection fraction,and the recently proposed category heart failure with mid-range ejection fraction.One could envisage specific sets of biomarker with different performances in heart failure progression with different left ventricular ejection fraction especially as concerns prediction of the future course of the disease and of left ventricular adverse/reverse remodeling.This article is intended to provide an overview of basic and additional mechanisms of heart failure progression will contribute to a more comprehensive knowledge of the disease pathogenesis. | Ekaterina A Polyakova Evgeny N Mikhaylov Dmitry L Sonin Yuri V Cheburkin Mikhail M Galagudza | 2021 | Journal of Geriatric Cardiology2021，18，1： | 4 |
| 2 | Serdinl/ Lrrcl0 is dispensable for mouse development 显示文摘 | NIKOLAY L MANUYLOV EKATERINA M | 2008 | Genesis2008，46，： | 1 |
| 3 | Serdinl/LrrclO is dispensable for mouse development 显示文摘 | NIKOLAY L M EKATERINA M VALERIYA A | 2008 | Genesis2008，46，： | 1 |
| 4 | Magnetoencephalography in presurgical epilepsy evaluation显示文摘 | Ekaterina Pataraia Christoph Baumgartner Gerald Lindinger Lüder Deecke | 2002 | Neurosurgical Review2002，，3： | 1 |
| 5 | The effect ofelectrodialytic treatment and Na2 H2 EDTA addition onmethanogenic activity of copper-amended anaerobic granularsludge: treatment costs and energy consumption 显示文摘 | JURATE V EKATERINA R PIET L | 2011 | BioresourceTechnology2011，102，9： | 1 |
| 6 | Express detection of nonylphenol in water samples by fluorescence polarization immunoassay显示文摘 | Julia N Y Anna Y L Ekaterina A | 2004 | Anal Bioanal Chem2004，378，3： | 1 |
| 7 | Determination of overlappingpeaks heights by tangent method显示文摘 | EKATERINA L SERGE R | 2012 | Strategic Technolo-gy(IFOST)2012，，： | 1 |
| 8 | Disease modifying treatment of spinal cord injury with directly reprogrammed neural precursor cells in non-human primates显示文摘BACKGROUND The development of regenerative therapy for human spinal cord injury(SCI)is dramatically restricted by two main challenges:the need for a safe source of functionally active and reproducible neural stem cells and the need of adequate animal models for preclinical testing.Direct reprogramming of somatic cells into neuronal and glial precursors might be a promising solution to the first challenge.The use of non-human primates for preclinical studies exploring new treatment paradigms in SCI results in data with more translational relevance to human SCI.AIM To investigate the safety and efficacy of intraspinal transplantation of directly reprogrammed neural precursor cells(drNPCs).METHODS Seven non-human primates with verified complete thoracic SCI were divided into two groups:drNPC group(n=4)was subjected to intraspinal transplantation of 5 million drNPCs rostral and caudal to the lesion site 2 wk post injury,and lesion control(n=3)was injected identically with the equivalent volume of vehicle.RESULTS Follow-up for 12 wk revealed that animals in the drNPC group demonstrated a significant recovery of the paralyzed hindlimb as well as recovery of somatosensory evoked potential and motor evoked potential of injured pathways.Magnetic resonance diffusion tensor imaging data confirmed the intraspinal transplantation of drNPCs did not adversely affect the morphology of the central nervous system or cerebrospinal fluid circulation.Subsequent immunohistochemical analysis showed that drNPCs maintained SOX2 expression characteristic of multipotency in the transplanted spinal cord for at least 12 wk,migrating to areas of axon growth cones.CONCLUSION Our data demonstrated that drNPC transplantation was safe and contributed to improvement of spinal cord function after acute SCI,based on neurological status assessment and neurophysiological recovery within 12 wk after transplantation.The functional improvement described was not associated with neuronal differentiation of the allogeneic drNPCs.Instead,directed drNPCs migration to the areas of active growth cone formation may provide exosome and paracrine trophic support,thereby further supporting the regeneration processes. | Vladimir P Baklaushev Oleg V Durov Vladimir A Kalsin Eugene V Gulaev Sergey V Kim Ilya L Gubskiy Veronika A Revkova Ekaterina M Samoilova Pavel A Melnikov Dzhina D Karal-Ogly Sergey V Orlov Alexander V Troitskiy Vladimir P Chekhonin Alexander V Averyanov Jan-Eric Ahlfors | 2021 | World Journal of Stem Cells2021，13，5： | 1 |
| 9 | Synthesis of fluorescent coumarin triazoly] glycosides显示文摘 | ALEXANDER V N EKATERINA A S NINA A L | 2011 | Tet- rahedron Lett2011，52，： | 1 |
| 10 | Influence of the operating temperature on the ageing and interfaces of double layer polymer electrolyte solid state Li metal batteries显示文摘Solid-state lithium metal batteries(SSLMBs)are considered an auspicious technology to develop high energy density and safe energy storage devices.The double layer polymer electrolyte(DLPE)is a rational approach for engineering high-performance SSLMBs addressing electrolyte requirements with specifically designed polymers at the positive electrode and as separator.In this work,SSLMBs were assembled with poly(propylene carbonate)(PPC),offering stability toward oxidation at the positive electrode,and a gel polymer electrolyte with polyethyleneglycol dimethylether(PEGDME)as separator,offering high ionic conductivity at low temperature and sufficient interfacial stability with Li metal.The electrochemical properties and performance of cells with LiFePO_(4) and Li[Ni_(0.6)Mn_(0.2)Co_(0.2)]O_(2) positive electrodes are thoroughly investigated as function of the operating temperature by using a host of characterization techniques.High-voltage cells with an areal capacity of 0.7 mAh·cm^(−2)cycled at 40℃ exhibit a higher capacity retention than the cells cycled at 70℃.To understand such differences,a three-electrode setup is applied to discriminate anodic processes from cathodic as function of the temperature.We elucidate the ageing and interfacial evolution for DLPE cells with gel polymer electrolytes paving the way for building performance solid state batteries. | Mikel Arrese-Igor María Martinez-Ibañez Ander Orue Ekaterina Pavlenko Erwan Dumont Michel Armand Frédéric Aguesse Pedro López Aranguren | 2023 | Nano Research2023，16，6： | 0 |
| 11 | Anatomical structure of Aconitum napellus over ground part and subterranean organs显示文摘Aconite or monkshood is various and counts as many as 300 types.All types can be distinguished by color of flowers,flower galea heights,number of follicles and mostly,by their root system[1].Aconitum napellusL.belongs to napellus section[2-3]and has a root system,consisiting of 1-2 juicy tuberiform rhizomes with tiny side roots[4] | Tatiana L Kiseleva Ekaterina Y Ladyiguina Larisa N Frolova Nina N Melnikova Elena V Tsvetayeva Julia A Smirnova | 2010 | 中国中药杂志2010，35，5： | 0 |
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