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| 1 | Production of radioactive ~9C ion beam and its optimization显示文摘To explore the medical use of a radioactive 9C-ion beam in tumor treatment, which is a double radiation source coming from the external beam itself and the delayed particles emitted internally, some physical experiments are performed at the Secondary Beam Line (SBL) of Heavy Ion Medical Accelerator, Chiba (HIMAC) in Japan be- fore radiobiological research for exhibiting therapeutic value of the 9C beam. Intention of the experiments is for pro- ducing a radioactive 9C-ion beam with higher production rate and purity by means of optimizing the beam line pa- rameters. Finally, a produced 9C beam with the production rate of 9.07×10-6 and purity of 82.88% at full momentum acceptance has been obtained under the optimal conditions of 40 mm-thick beryllium target and 10 mm-thick alumi- num degrader. Both momentum distribution and contaminations for the produced 9C beam under the optimal condi- tions are measured. In order to execute further biological experiments of the 9C beam project, a uniform irradiation field is made with the wobbling magnets and its homogeneity is up to 93.8% inside central area of 20mm in diameter. | WEIZeng-Quan LIQiang A.KITAGAWA T.KANAI M.KANAZAWA E.URAKABE XIEHong-Mei ZHOUGuang-Ming | 2005 | Nuclear Science and Techniques2005，16，2： | 3 |
| 2 | 放射性离子束^(9)C的细胞生物学效应显示文摘首先介绍了重离子束治癌的特点及当前的技术进步, 着重讨论了放射性离子束(RIB)在肿瘤治疗上增添的优势, 详细叙述了在日本放射医学综合研究所(NIRS)重离子医用加速器(HIMAC)上旨在肿瘤治疗的放射性离子束 C 的实验研究, 包括束流产生、参数优化、深度物理剂量分布、细胞辐照后的存 9活效应以及 C 和 C 束的相对生物效率(RBE)比较. 最终结果: 在40 mm 厚铍靶、10 mm 厚铝降能器、 9 125%动量接收度时, 采用 430 MeV/u、1.8×109 粒子/s 的初试束 C, 得到的 C 束的产生率为 9.07×10?6, 12 9纯度为 82.88%, 采用点扫描技术时, 在直径为 10 mm 的中心面积内, 可获得均匀度为 89.6%的辐照场,这时在入口处的剂量率为0.5Gy/h. 在Bragg峰附近范围内的细胞存活实验中, C束的平均RBE为5.28, 9而 C 束的平均 RBE 为 2.93, C 束的 RBE 要比 C 束的高1.8 倍, 这显示 C 束在 Bragg 峰附近范围内, 12 9 12 9对细胞的杀伤力要比 C 强, 在肿瘤治疗上会更有效. | 卫增泉 李强 A.Kitagawa T.Kanai M.Kanazawa Y.Furusawa E.Urakabe 颉红梅 周光明 | 2005 | 科学通报2005，50，5： | 2 |
| 3 | Biological effects of radioactive ~9C-ion beams on cells显示文摘The distinguishing feature and current technique progress of tumor treatment with heavy-ion beams is introduced in the paper. Additional superiority to tumor treatment from a radioactive ion beam (RIB) is emphatically discussed. The experimental research of the radioactive 9C-ion beams aimed at tumor treatment at Heavy Ion Medical Accelerator in Chiba (HIMAC), National Institute of Radiological Sciences (NIRS), Japan is described in detail, La-eluding production of the beams, optimization of parameters, distribution of depth dose, survival effect of cell and comparison of RBE between 9C- and 12C-beams. Results show that under 40 mm thick Beryllium target and 10 mm thick aluminum degrader at full (5%) momentum acceptance, the production rate and purity of the produced 9C-beams are 9.07×10-6 and 82.88% respectively with the primary 12C-beams of 430 MeV/u and 1.8×109 pps. A uniform irradiation field with homogeneity up to 89.6% inside central area 10 mm in diameter is obtained by using spot scanning. In this case, the dose rate at the entrance is 0.5 Gy/h. In survival experiment of cells, the average relative biological effectiveness (RBE) of 9C-beams is 5.28 and 2.93 for 12C-beams in the region around Bragg peak. The RBE of 9C-beams is 1.8 times higher than that of 12C-beams. It indicates that cell-killing efficiency of 9C-beams is stronger than that of 12C-beams. 9C-beams are more efficacious for tumor treatment than 12C-beams. | WEIZengquan LIQiang A.Kitagawa T.Kanai M.Kanazawa Y.Furusawa E.Urakabe XIEHongmei ZHOUGuangming | 2005 | Chinese Science Bulletin2005，50，11： | 2 |
| 4 | 低剂量率下高线性能量转移碳离子束辐照人类唾液腺细胞的存活效应显示文摘利用日本千叶重离子医用加速器HIMAC提供的碳离子束,对人类唾液腺细胞(HSG)在剂量率为0.5Gy/h的低剂量率条件下进行了辐照,运用标准的克隆形成法得到了3种不同剂量平均线性能量转移(LET)碳离子束辐照HSG细胞的剂量存活效应.与先前HSG细胞在治癌剂量率(1￣5Gy/min)下对相近剂量平均LET碳离子束辐照的剂量存活效应数据相比,HSG细胞对高LET碳离子束辐射表现出明显的剂量率效应.为在相同条件下得到碳离子束对HSG细胞的相对生物学效应(RBE),利用60Co-#射线在剂量率为0.5Gy/h的条件下辐照了HSG细胞,得到该细胞系对低LET射线响应的剂量存活效应.与先前在治癌剂量率下得到的RBE值相比,低剂量率条件下得到的RBE值总体减小.由实验发现的剂量率效应及低剂量率条件下RBE值的减小,表明由高LET碳离子束造成的辐射损伤在低剂量率条件下也存在着显著的修复效应.据此,对辐射造成细胞致死的原因进行了探讨. | 李强 Y.FURUSAWA M.KANAZAWA M.AOKI E.URAKABE S.SATO | 2005 | 生物化学与生物物理进展2005，32，9： | 0 |
| 5 | 放射性^9C束流不同贯穿深度上的线能谱测量显示文摘为阐述放射性9C束流应用于治癌的物理基础,运用一个球形生物组织等效正比计数器测量了9C束流不同贯穿深度上的线能谱,得到了沿束流贯穿深度上的剂量平均线能分布.将实验测量得到的线能谱转换成为不同传能线密度在吸收剂量中所占份额的分布,得到了该9C束流在不同贯穿深度上的剂量平均传能线密度分布.将生物组织等效正比计数器测量得到的与先前通过平行板正比计数器测量得到的该9C束流的剂量平均传能线密度分布进行比较,发现:在束流入射通道上,两者测量数据符合很好,而在束流Bragg峰附近9C离子的沉积区域,由组织等效正比计数器测量得到的剂量平均传能线密度值大于由平行板正比计数器测量得到的值. | 李强 N.Matsufuji E.Urakabe M.Kanazawa S.Sato | 2005 | 高能物理与核物理2005，29，11： | 0 |
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