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| 1 | SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity显示文摘Chondrocytes and osteoblasts differentiate from a common mesenchymal precursor, the osteochondroprogenitor(OCP), and help build the vertebrate skeleton. The signaling pathways that control lineage commitment for OCPs are incompletely understood. We asked whether the ubiquitously expressed protein-tyrosine phosphatase SHP2(encoded by Ptpn11) affects skeletal lineage commitment by conditionally deleting Ptpn11 in mouse limb and head mesenchyme using 'Cre-lox P'-mediated gene excision.SHP2-deficient mice have increased cartilage mass and deficient ossification, suggesting that SHP2-deficient OCPs become chondrocytes and not osteoblasts. Consistent with these observations, the expression of the master chondrogenic transcription factor SOX9 and its target genes Acan, Col2a1, and Col10a1 were increased in SHP2-deficient chondrocytes, as revealed by gene expression arrays, q RT-PCR, in situ hybridization, and immunostaining. Mechanistic studies demonstrate that SHP2 regulates OCP fate determination via the phosphorylation and SUMOylation of SOX9, mediated at least in part via the PKA signaling pathway. Our data indicate that SHP2 is critical for skeletal cell lineage differentiation and could thus be a pharmacologic target for bone and cartilage regeneration. | Chunlin Zuo Lijun Wang Raghavendra M.Kamalesh Margot E.Bowen Douglas C.Moore Mark S.Dooner Anthony M.Reginato Qian Wu Christoph Schorl Yueming Song Matthew L.Warman Benjamin G.Neel Michael G.Ehrlich Wentian Yang | 2018 | Bone Research2018，6，2： | 3 |
| 2 | THE ROLE OF SUPPLY MANAGEMENT CAPABILITIES IN GREEN SUPPLY显示文摘 | FRANCES E.BOWEN PAUL D.COUSINS RICHARD C.LAMMING ADAM C.FARUKT | 2009 | Production and Operations Management2009，，2： | 2 |
| 3 | Hiring for the organization,not the job显示文摘 | David E.Bowen Gerald E.Ledford Barry R.Nathan | | 0，，04： | 1 |
| 4 | The role of p53 in developmental syndromes显示文摘While it is well appreciated that loss of the p53 tumor suppressor protein promotes cancer,growing evidence indicates that increased p53 activity underlies the developmental defects in a wide range of genetic syndromes.The inherited or de novo mutations that cause these syndromes affect diverse cellular processes,such as ribosome biogenesis,DNA repair,and centriole duplication,and analysis of human patient samples and mouse models demonstrates that disrupting these cellular processes can activate the p53 pathway.Importantly,many of the developmental defects in mouse models of these syndromes can be rescued by loss of p53,indicating that inappropriate p53 activation directly contributes to their pathogenesis.A role for p53 in driving developmental defects is further supported by the observation that mouse strains with broad p53 hyperactivation,due to mutations affecting p53 pathway components,display a host of tissue-specific developmental defects,including hematopoietic,neuronal,craniofacial,cardiovascular,and pigmentation defects.Furthermore,germline activating mutations in TP53 were recently identified in two human patients exhibiting bone marrow failure and other developmental defects.Studies in mice suggest that p53 drives developmental defects by inducing apoptosis,restraining proliferation,or modulating other developmental programs in a cell type-dependent manner.Here,we review the growing body of evidence from mouse models that implicates p53 as a driver of tissue-specific developmental defects in diverse genetic syndromes. | Margot E.Bowen Laura D.Attardi | 2019 | Journal of Molecular Cell Biology2019，11，3： | 1 |
| 5 | Energy Driven by Internet of Things Analytics and Artificial Intelligence显示文摘Developing an integrated and intelligent approach to securing the ITE(information technology environment)is an emergent and evolving concern for every organization and consumer entity during the last few decades.Major topics of concern include“SI”(security intelligence),“D-DA”(data-driven analytics),“PE”(proven expertise),and“R-TD”(real-time defense)capabilities.“DRBTs”(dynamic response behavior types)include“incident response”,“endpoint management”,“threat intelligence”,“network security”,and“fraud protection”.The consumer demand for electricity as essential public access and service is indexed to population growth estimates.Consumer-driven economies continue to add electrical consumption to their grids even though improvements in lower-power consumption and higher design efficiencies are present in new electric-powered products.Dependence on the production of electrical energy has no peer replacement technology and creates a societal vulnerability to targeted public electrical grid interruptions.When access to,or production of,electrical power is interrupted,the result is a“Mass Effect”every consumer feels with equal distribution.Electric grid security falls directly into the levels of authorized,and unauthorized,access via the“IoT”(Internet of Things)concepts,and the“IoM2M”(Internet of Machine-to-Machine)integration.Electrical grid operations that include production and network management augment each other in order to support the demand for electricity every day either in peak or off-peak,thus cybersecurity plays a big role in the protection of such assets at our disposal.With help from AI(artificial intelligence)integrated into the IoT a resilient system can be built to protect the electric grid system nationwide and will be able to detect and preempt Smart Malware attacks. | Bahman Zohuri Paul E.Bowen Akansha Agarwal Dinesh Kumar Masoud Moghaddam | 2022 | Journal of Energy and Power Engineering2022，16，1： | 0 |
| 6 | 用DRIS和临界值法对番木瓜组织分析数据的分析比较显示文摘用综合诊断施肥法(DRIS)和临界值法鉴定温室沙培及商业大田定植番木瓜(Papaya carica L.,cv.Solo)的矿质营养缺乏情况。无矿质营养缺乏症(即“完全”处理)的沙培植株,DRIS指数全为正值,表明植株的生长和发育确实没有营养限制,根据DRIS,肉眼可看出缺乏症的大田植株,其刚老熟叶片的叶柄最缺乏的元素是P、Fe和Zn。在所有出现营养不平衡症状的植株中,P的浓度低于临界水平。这些植株的DRIS指数为负值可证实这点。Fe和Zn的DRIS指数也为负值,表明这些微量元素可能不足。然而,组织中Fe和Zn的实际浓度完全处于或高于适宜范围。因此,毒性可能是在症状表现方面起作用的因素,尤其是Zn。与健康的植株比较,不健康植株的镁浓度增加,但DRIS指数未能确定这是起作用的因素。DRIS结合临界值法分析植株组织的分析数据,似乎是鉴定番木瓜营养缺乏的一种有效手段。 | John E.Bowen 张华平 | 1993 | 世界热带农业信息1993，0，3： | 0 |
| 7 | 如何预防顾客失误显示文摘大多数人往往忽略了顾客在提高服务质量过程中的作用,设想一下,如果你不努力,那么再优秀的健美教练也不能帮你塑造出好的体形。既然顾客在服务过程中扮演着和服务提供商一样重要的角色,那么我们应该采取措施来减少顾客的失误。我们列举了五类预防顾客失误的战略。 | Stephen S.Tax Mark Colgate David E.Bowen 康路(编译) | 2006 | 商学院2006，，7： | 0 |
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