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| 1 | Comethylation of p16 and MGMT genes in colorectal carcinoma:Correlation with clinicopathological features and prognostic value显示文摘AIM: To investigate the significance of p16 and O6- methylguanine-DNA methyltransferase (MGMT) genes promoter hypermethylation and K-ras mutations on colorectal tumorigenesis and progression. METHODS: p16 and MGMT methylation status was examined on 47 tumor samples, and K-ras mutational status was examined on 85 tumor samples. For methylation analysis, a methylation specific PCR (MS-PCR) method was used. RESULTS: p16 and MGMT promoter methylation was found in 51% (24/47) and 43% (20/47) of CRCs, respectively, and the K-ras mutation was found in 44% (37/85) of CRCs. Comethylation of p16 and MGMT genes was significantly associated with lower aggressiveness of the disease within a two-year period of observation. Only 27% of patients with simultaneous p 16 and MGMT methylation showed the detectible occurrence of metastasis and/or death, compared to 67% of patients without double methylation or with no methylation (3/11 vs 22/33, P < 0.05, χ2-test). In addition, p16 and MGMT comethylation showed a trend toward an association with longer survival in patients with CRCs (35.5 ± 6.0 mo vs 23.1 ± 3.2 mo, P = 0.072, Log-rank test). Progression of the disease within a two-year period was observed in 66% of patients carrying the K-ras mutation, compared to only 19% of patients with wild type K-ras (29/44 vs 7/37, P < 0.001, χ2-test). The presence of the K-ras mutation significantly correlated to shortened overall survival (20.0 ± 1.9 mo vs 37.0 ± 1.8 mo, P < 0.001, Log-rank test). The comethylation of p16 and MGMT genes was significantly associated with lower aggressiveness of the disease even when K-ras mutations were included in the analysis as an independent variable. CONCLUSION: Our data suggest that comethylation of promoters of p 16 and MGMT genes could have a prognostic value in patients with CRC. Specifically, concurrent methylation of both genes correlates with better prognosis. | Koviljka Krtolica Milena Krajnovic Slavica Usaj-Knezevic Dragan Babic Dusan Jovanovic Bogomir Dimitrijevic | 2007 | World Journal of Gastroenterology2007，13，8： | 10 |
| 2 | AlFe层柱粘土催化剂催化甲苯在水中的降解(英文)显示文摘The catalytic wet peroxide oxidation (CWPO) of toluene on two bentonite-based AlFe-pillared clays (PILCs) with different iron contents was investigated. The PILCs were obtained using bentonite clay from Bogovina,Serbia. The change in chemical and phase composition and textural properties of the starting clay and synthesized catalysts was monitored using X-ray diffraction,inductively coupled plasma optical emission spectrometry,UV-Vis diffuse reflectance spectrometry,and physisorption of nitrogen. The catalytic performance was examined using gas chromatography. The Na-exchange process lowered the (001) smectite basal plane spacing,but the clay retained its swelling properties,while the pillaring process increased it. The surface areas of both synthesized pillared clays increased to similar values although their Fe content was different. At 37 ℃,both catalysts show significant toluene degradation,with the one richer in Fe having higher efficiency. The leaching of the active cations during reaction was negligible,and the catalysts were stable. AlFe-pillared clay catalysts can be used in CWPO for the elimination of BTEX compounds from plant effluent streams. | Predrag BANKOVIC Aleksandra MILUTINOVIC-NIKOLIC Zorica MOJOVIC Aleksandra ROSIC ZeljkoUPIC Davor LONAREVIC Dusan JOVANOVIC | 2009 | 催化学报2009，30，1： | 1 |
| 3 | Pro- perties of copper matrix reinforced with nano-and micro- sized A12 03 particles显示文摘 | Viseslava Rajkovic Dusan Bozic Milan T Jovanovic | 2008 | J Alloys Compd2008，459，： | 1 |
| 4 | Giant pseudoaneurysm of the splenic artery within walled of pancreatic necrosis on the grounds of chronic pancreatitis显示文摘Chronic pancreatitis is a long-standing inflammation of the pancreas,characterized by progressive inflammatory and fibrotic changes,resulting in permanent structural damage of pancreatic parenchyma[1].Pancreatitis(chronic or acute)is the primary risk factor for pseudo-splenic artery aneurysms,along with pancreatic pseudocysts and trauma.As the disease progresses,patients with chronic pancreatitis may develop complications due to exocrine and endocrine pancreatic functional loss,such as fat malabsorption with steatorrhea,glucose intolerance,and ultimately diabetes mellitus[1,2].Furthermore,severe pancreatic inflammation can cause weakening of vessel walls,with subsequent formation of arterial pseudoaneurysms.Splenic artery is the most commonly affected visceral artery[2,3].Liver cirrhosis,portal hypertension,liver transplantation,atherosclerosis,hypertension,pregnancy and multiparity are main risk factors for true splenic artery aneurysms[2].Rupture and intraperitoneal bleeding is the cause of death in 30%−50%of patients.Thus,prompt diagnosis and appropriate treatment are of great clinical importance[4,5].Herein,we present a case of a giant splenic artery pseudoaneurysm within a walled of necrosis involving pancreatic parenchyma,as a complication of long standing chronic pancreatitis. | Milica Mitrovic Jovanovic Dusan Saponjski Aleksandra Djuric Stefanovic Aleksandra Jankovic Stefan Milosevic Katarina Stosic Djordje Knezevic Jelena Kovac | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，1： | 1 |
| 5 | Educational Games Design Issues: Motivation and Muhimodal Interaction 显示文摘 | Mladjan Jovanovic Dusan Starcevic Velimir Stavljanin Miroslav Minovic | 2008 | WSKS2008，5288，： | 1 |
| 6 | Effects of copper and Al 2 O 3 particles on characteristics of Cu–Al 2 O 3 composites显示文摘 | Viseslava Rajkovic Dusan Bozic Milan T. Jovanovic | 2009 | Materials and Design2009，，4： | 1 |
| 7 | Adsorption of Pb^2+, Cd^2+ and Sr^2+ ions onto natural and acid-activated sepiolites显示文摘 | Slavica Lazarevic Ivona Jankovic-Castvan Dusan Jovanovic | 2007 | Applied Clay Science2007，37，12： | 1 |
| 8 | Properties of copper matrix reinforced with various size and amount of Al 2 O 3 particles显示文摘 | Viseslava Rajkovic Dusan Bozic Milan T. Jovanovic | 2007 | Journal of Materials Processing Tech2007，，1： | 1 |
| 9 | Effects of copper and AI2 03 particles on characteristics of Cu-A12 03 composites显示文摘 | Viseslava Rajkovic Dusan Bozic Milan T Jovanovic | 2010 | Mater Des2010，31，： | 1 |
| 10 | Shareholders' Duty of Loyalty and Positive Voting Duty显示文摘 | Borut Bratina Dusan Jovanovic | 2014 | China-USA Business Review2014，13，5： | 0 |
| 11 | MODIFICATION OF THE SLOVENIAN COMPANIES ACT AND IMPROVEMENT OF CORPORATE GOOD PRACTISE显示文摘 | Dr. Dusan Jovanovic Dr. Borut Bratina | 2016 | US-China Law Review2016，13，8： | 0 |
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