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| 1 | Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma显示文摘Pancreatic cancer(Pa C) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers. It focuses on the anomalous glycosylation process and its role in PaC. Glycan structures of glycoconjugates such as glycoproteins are modified in tumors and these modifications can be detected in biological fluids of the cancer patients. Several studies have found serum glycoproteins with altered glycan chains in PaC patients, but they have not shown enough specificity for PaC. To find more specific cancer glycoproteins we propose to analyze the glycan moieties of a battery of glycoproteins that have been reported to increase in PaC tissues and that can also be found in serum. The combination of these new candidate glycoproteins with their aberrant glycosylation together with the existing biomarkers could result in a panel, which would expect to give better results as a new tool for early diagnosis of PaC and to monitor the disease. | Esther Llop Pedro E Guerrero AdriàDuran Sílvia Barrabés Anna Massaguer María JoséFerri Maite Albiol-Quer Rafael de Llorens Rosa Peracaula | 2018 | World Journal of Gastroenterology2018，24，24： | 4 |
| 2 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 3 | Cerium hybrid silica coatings on stainless steel AISI 304 substrate显示文摘 | PEPE A APARICIO M DURAN A | 2006 | Journal of Sol-Gel Science and Technology2006，39，2： | 1 |
| 4 | Regudation of Na^+/K^+-ATPase in prostate cancer:a role for PKC显示文摘 | Duran M J Pressley Thomas A | 2007 | FASEB2007，21，： | 1 |
| 5 | Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation 显示文摘 | Gow A J Duran D Malcolm S Ischiropoulos H | 1996 | Febs Lett1996，385，12： | 1 |
| 6 | The endometrial ablator: a new instrument 显示文摘 | Neuwirth RS Duran AA Singer A | 1994 | Obstet Gynecol1994，83，5： | 1 |
| 7 | Drug-induced hyponatremia: an updated review显示文摘 | Ramos-Levi AM Duran Rodriguez-Hervada A Mendez-Bailon M | 2014 | Minerva Endocrinol2014，39，1： | 1 |
| 8 | Some chemical and toxicological aspects about paper mill effluent treatment with ozone显示文摘 | Freire R S Kunz A Duran N | 2000 | Environmental Technology2000，21，： | 1 |
| 9 | Abstract Specification and Formalization of an Operating System Kernel in Z显示文摘 | Barreto L Andrade A Duran A | 2011 | ACM SIGOPS Operating Systems Review2011，45，1： | 1 |
| 10 | Evidence based medical treatment of heart failure显示文摘 | Agusti Escasany A Duran Dalmau M Arnau De Bolos JM | 2001 | Rev Esp Cardiol2001，54，： | 1 |
| 11 | In vitro dentine permeability evaluation of HEMA-based(desensitizing) products using split-chamber model following in vivo application in the dog显示文摘 | Duran I Senqun A Yildirim T | 2005 | J Oral Rehabilitation2005，32，1： | 1 |
| 12 | Modeling and simulation of the HADA reconfigurable UAV显示文摘 | Heredia G Duran A Ollero A | 2012 | Journal of Intelligent and Robotic Systems2012，65，14： | 1 |
| 13 | Progression of tricuspid regurgitation after repaired functional ischemic mitral regurgitation显示文摘 | Matsunaga A Duran CM | 2005 | Circulation2005，112，9： | 1 |
| 14 | System dynamics urban sustainability model for Puerto aura in Puebla,Mexico显示文摘 | Jorge A Duran E Alberto P C | 2009 | Systemic Practice and Action Research2009，22，2： | 1 |
| 15 | Physicochemical characteristics of a novel activated carbon producedfrom tea industry waste显示文摘 | Gundogdu A Duran C Senturk H B | 2013 | Journal of Analytical and Applied Pyrolysis2013，104，11： | 1 |
| 16 | Puma IS diesel engine oil pan assembly NVH optimization with optistruct and AVL excite显示文摘 | DURAN E T SEVER A C | 2006 | Simulation2006，，1： | 1 |
| 17 | Adsorption of phenol from aqueous solution on a low-cost activated carbon produced from tea industry waste: Equilibrium, kinetic, and thermodynamic study显示文摘 | Gundogdu A Duran C Senturk H B | 2012 | Journal of Chemical & Engineering Data2012，57，10： | 1 |
| 18 | Randomized Clinical Trial of Cognitive Behavioral Stress Management on Human Immunodeficiency Virus Viral Load in Gay Men Treated With Highly Active Antiretroviral Therapy显示文摘 | Antoni M Carrcio A Duran R | 2006 | Psychosomatic Medicine2006，68，1： | 1 |
| 19 | Endotoxin contamination of patenteral drugs and radiopharmaceuticals as determined by the limulus amebocyte lysate method显示文摘 | Twohy C W Duran A P Munson T E | 1984 | J Parenter Sci Technol1984，38，5： | 1 |
| 20 | Effects of energy back transfer on the luminescence of Yb and Er ions in YAG 显示文摘 | VEGA - DURAN J T BARBOSA - GARCIAO DIAZ - TORRES L A | 2000 | Appl Phys Lett2000，76，15： | 1 |
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