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| 1 | Single-cell transcriptomic atlas of primate cardiopulmonary aging显示文摘Aging is a major risk factor for many diseases,especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019(COVID-19).Resolving cellular and molecular mechanisms associated with aging in higher mammals is therefore urgently needed.Here,we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung,heart and artery,the top tissues targeted by SARS-CoV-2.Analysis of cell type-specific aging-associated transcriptional changes revealed increased systemic inflammation and compromised virus defense as a hallmark of cardiopulmonary aging.With age,expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2(ACE2)was increased in the pulmonary alveolar epithelial barrier,cardiomyocytes,and vascular endothelial cells.We found that interleukin 7(IL7)accumulated in aged cardiopulmonary tissues and induced ACE2 expression in human vascular endothelial cells in an NF-κB-dependent manner.Furthermore,treatment with vitamin C blocked IL7-induced ACE2 expression.Altogether,our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2,suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly. | Shuai Ma Shuhui Sun Jiaming Li Yanling Fan Jing Qu Liang Sun Si Wang Yiyuan Zhang Shanshan Yang Zunpeng Liu Zeming Wu Sheng Zhang Qiaoran Wang Aihua Zheng Shuguang Duo Yang Yu Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Moshi Song Weiqi Zhang Guang-Hui Liu | 2021 | Cell Research2021，31，4： | 10 |
| 2 | Elucidation of the sodium kinetics in layered P-type oxide cathodes显示文摘Sodium-ion intercalation oxides generally possess high compositional diversity according to their different stacking sequences.The sodium diffusion pathway in layered P-type materials used in sodium-ion batteries is open,which can increase their rate capability by directly transmitting Na+between adjacent triangular prismatic channels,rather than passing through an intermediate tetrahedral site in O-type structure.However,how the structure chemistry of the P-type oxides determines their electrochemical properties has not been fully understood yet.Herein,by comparing the crystalline structures,electrochemical behaviors,ion/electron transport dynamics of a couple of P-type intercalation cathodes,P2-Na_(2/3)Ni1/3Mn_(2/3)O_(2)and P3-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)with the same compositions,we demonstrate experimentally and computationally that the P2 phase delivers better cycling stability and rate capability than the P3 counterpart due to the predominant contribution of the faster intrinsic Na diffusion kinetics in the P2 bulk.We also point out that it is the electronic conductivity that captures the key electrochemistry of layered P3-type materials and makes them possible to enhance the sodium storage performance.The results reveal that the correlation between stacking structure and functional properties in two typical layered P-type cathodes,providing new guidelines for preparing and designing alkali-metal layered oxide materials with improved battery performance. | Lianzheng Yu Haojie Dong Yu-Xin Chang Zhiwei Cheng Kang Xu Yi-Hu Feng Duo Si Xu Zhu Mengting Liu Bing Xiao Peng-Fei Wang Sailong Xu | 2022 | Science China Chemistry2022，65，10： | 3 |
| 3 | E17110 promotes reverse cholesterol transport with liver X receptor β agonist activity in vitro显示文摘Liver X receptor(LXR) plays an important role in reverse cholesterol transport(RCT), and activation of LXR could reduce atherosclerosis. In the present study we used a cell-based screening method to identify new potential LXRβ agonists. A novel benzofuran-2-carboxylate derivative was identified with LXRβ agonist activity: E17110 showed a significant activation effect on LXRβ with an EC50 value of 0.72 μmol/L. E17110 also increased the expression of ATP-binding cassette transporter A1(ABCA1) and G1(ABCG1) in RAW264.7 macrophages. Moreover, E17110 significantly reduced cellular lipid accumulation and promoted cholesterol efflux in RAW264.7 macrophages. Interestingly, we found that the key amino acids in the LXRβ ligand-binding domain had distinct interactions with E17110 as compared to TO901317. These results suggest that E17110 was identified as a novel compound with LXRβ agonist activity in vitro via screening, and could be developed as a potential anti-atherosclerotic lead compound. | Ni Li Xiao Wang Peng Liu Duo Lu Wei Jiang Yanni Xu Shuyi Si | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 3 |
| 4 | Serum phospholipid omega-3 polyunsaturated fatty acids and insulin resistance in type 2 diabetes mellitus and non-alcoholic fatty liver disease显示文摘 | Da-jun Lou Qi-qian Zhu Xu-wei Si Li-li Guan Qiao-ying You Zhong-ming Yu Ai-zhen Zhang Duo Li | 2014 | Journal of Diabetes and Its Complications2014，，： | 1 |
| 5 | An Evolutionary Algorithm to Optimization of Discrete Problem Based on Pheromone显示文摘The pheromone based positive feedback approach of ant algorithm is introduced in evolutionary computation of discrete problem, so as to accomplish the optimization of each allele. It ensures stable converge of the algorithm into global optimum. The optimal cutting problem is studied as an example to analyze the performance of the algorithm. The experimental results show the novel performance of the algorithm in the optimization of discrete problem. | Huang Zhang can 1, Wu Fang cai 2, Chen Si duo 2 1.Department of Mathematics,Eastern Campus Wuhan University of Technology, Wuhan 430070, China 2.Department of Automation, Eastern Campus Wuhan University of Technology, Wuhan 430070,China | 2001 | Wuhan University Journal of Natural Sciences2001，6，Z1： | 0 |
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