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26篇 您的检索式:作者名="Du LX"
    题名 作者 年代 出处 被引量
1脊髓中TRPV4依赖的神经免疫轴促进神经病理性疼痛显示文摘小胶质细胞是中枢神经系统(central nervous system, CNS)的驻留巨噬细胞,对大脑的发育和稳态至关重要,并参与疾病发生。小胶质细胞的活化和增殖是包含神经病理性疼痛在内的诸多中枢神经系统疾病的标志。然而,在神经病理性疼痛中控制脊髓神经免疫轴的分子机制仍不完全清楚。该研究发现,基因敲除或药物阻断瞬时感受器电位香草素受体4 (transient receptor potential vanilloid 4, TRPV4)可显著减轻坐骨神经分支选择性损伤模型小鼠的神经病理性疼痛样行为。在机制上,小胶质细胞表达的TRPV4介导小胶质活化和增殖,并促进脂质运载蛋白2 (lipocalin-2)释放,增加脊髓兴奋性神经元的可塑性。该研究揭示,小胶质细胞的TRPV4通道处于脊髓神经免疫轴中心,将周围神经损伤转化为中枢敏化和神经病理性疼痛,进而将TRPV4确定为治疗慢性疼痛的潜在新靶点。沈周阳(译) 唐宗湘(校) Hu XM Du LX Liu SB 2023中国疼痛医学杂志2023,29,11:1
2Phosphorylation modulates the local conformation and self - aggregation ability of a peptide from the fourth tau microtubule - binding repeat 显示文摘DU J T YU C H ZHOU LX 2007FEBS2007,274,19:1
3A novel maternal lineage re- vealed in sheep (Ovis aries) 显示文摘Guo J Du LX Ma YH 2005Animal Genetics2005,36,4:1
4Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells :effects on insulinlike growth factor I signaling显示文摘Nahta R Yuan LX Du Y 2007Mol Cancer Ther2007,6,2:1
5Purification and characterization of a novel fibrinolytic enzyme from Rhizopus chinensis 12 显示文摘Liu XL Du LX Lu FP 2005Applied Microbiology and Bioteehnology2005,67,2:1
6The CD226 gene in susceptibility of rheumatoid arthritis in the Chinese Han population显示文摘Du Y Shen LX Yu LK 2012Rheumatol Int2012,32,5:1
7Purification and characterization of a novel fibrinolytic enzyme from Rhizopus ehinensis 12 显示文摘LIU XL DU LX 2005Appl Microbiol Biotechnol2005,67,2:1
8Phosphorylation modu- lates the local conformation and self-aggregation ability of a peptide from the fourth tau microtubule binding repeat 显示文摘Du JT Yu CL Zhou LX 2007FEBS J2007,274,:1
9Phosphorylation modulates the local conformation and self-aggregation ability of a peptide from the fourth tau mierotubule-binding repeat显示文摘Du JT Yu CH Zhou LX 2007FEBS J2007,274,19:1
10Comparison of laboratory tests for bacterial vaginosis显示文摘Du LX Li FL Li SQ 2011Lab Med Clin2011,8,15:1
11Phosphorylation modulates the local conformation and self - aggregation ability of a peptide from the fourth tau microtubuXe - binding repeat 显示文摘Du JT Yu CH Zhou LX 2007FEBSJ2007,274,19:1
12Study on mutation breeding of the lipase producing strain Rhizopus arrhizus with low energy N ion beam implantation显示文摘Ji YZ Tan TW Du LX 2008Journal of Biotechnology2008,,:1
13Hydrogen sulphide-induced hy pothermia attenuates stress-related ulceration in rats 显示文摘Lou LX Geng B Du JB etal 2008Clin Exp Pharmacol Physiol2008,35,2:1
14Lapatinib induces apop- tosis in trastuzumab-resistant breast cancer cells: Effects on insulin-like growth factor 1 signaling显示文摘Nahta R Yuan LX Du Y 2007Mol Cancer Ther2007,6,2:1
15Using Surgical Microscope for Sclera Buckling and Transscleral Cryopexy: An Alternative Procedure of Treat- ment for Rhegmatogenous Retinal Detachment显示文摘Zhong LX Du Y Liu W 2014Biomed Res Int2014,,:1
16The CD226 gene in susceptibility of rheumatoid arthritis in the Chinese Han population 显示文摘Du Y Shen LX Yu LK 2012Rheumatol Int2012,32,:1
17, Optimization of the expression of a laccase gene from Trametes versicolor in Pichia methanolica显示文摘Guo M Lu FP Du LX 2006Applied Microbiology and Biotechnology2006,71,6:1
18Bioconversion of melhyl-testosterone in a biphasic system 显示文摘BIE ST DU LX ZHANG l M 2005Process Biochem2005,40,10:1
19Hydrogen suiphide induced hypothermia at tenuates stress-related ulceration in rats 显示文摘Lou LX Geng B Du JB 2008Clin Exp Phamacol Physiol2008,35,2:1
20A novel maternal lineage revealed in sheep (Ovis aries)显示文摘C-uo J Du LX Ma YH 2005Anim Genet2005,36,4:1
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