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| 1 | Exosomes: new molecular targets of diseases显示文摘细胞外的泡(EV ) 包括 apoptotic 身体, microvesicles 和 exosomes,并且他们象 diseased 状态一样在正常在 cell-to-cell 通讯作为关键管理者表演。EV 包含自然货物分子,例如 miRNA, mRNA 和蛋白质,并且通过循环把这些功能的货物转移到附近的房间或更多的远房间。这些机能上地活跃的分子然后影响不同发信号的串联。传送到接受者房间的消息依赖于 EV 的作文,它由父母房间和 EV 生物的续生说是坚定的。因为他们象在循环, biocompatibility,低 immunogenicity 和毒性的增加的稳定性那样的性质, EV 为治疗学作为吸引人的交货系统引起了注意。这评论在为治疗学的目的使用 exosomes 在治疗和潜在的优点和挑战集中于 exosomes 的功能的使用。 | Saheli SAMANTA Sheeja RAJASINGH Nicholas DROSOS Zhigang ZHOU Buddhadeb DAWN Johnson RAJASINGH | 2018 | Acta Pharmacologica Sinica2018，39，4： | 27 |
| 2 | Perioperative blood management strategies for patients undergoing total knee replacement:Where do we stand now?显示文摘Total knee replacement(TKR) is one of the most common surgeries over the last decade. Patients undergoing TKR are at high risk for postoperative anemia and furthermore for allogeneic blood transfusions(ABT). Complications associated with ABT including chills, rigor, fever, dyspnea, light-headedness should be early recognized in order to lead to a better prognosis. Therefore, perioperative blood management program should be adopted with main aim to reduce the risk of blood transfusion while maximizing hemoglobin simultaneously. Many blood conservation strategies have been attempted including preoperative autologous blood donation, acute normovolemic haemodilution, autologous blood transfusion, intraoperative cell saver, drain clamping, pneumatic tourniquet application, and the use of tranexamic acid. For practical and clinical reasons we will try to classify these strategies in three main stages/pillars: Pre-operative optimization, intra-operative and post-operative protocols. The aim of this work is review the strategies currently in use and reports our experience regarding the perioperative blood management strategies in TKR. | Tzatzairis Themistoklis Vogiatzaki Theodosia Kazakos Konstantinos Drosos I Georgios | 2017 | World Journal of Orthopedics2017，8，6： | 13 |
| 3 | Persistent post-surgical pain and neuropathic pain after total knee replacement显示文摘AIM: To study the prevalence of persistent post-surgical pain(PPSP) and neuropathic pain(NP) after total knee replacement(TKR).METHODS: MEDLINE and Embase databases were searched for articles published until December 2014 in English language. Published articles were included if they referred to pain that lasts at least 3 mo after primary TKR for knee osteoarthritis, and measured pain with pain specific instruments. Studies that referred to pain caused by septic reasons and implant malalignment were excluded. Both prospective and retrospective studies were included and only 14 studies that match the inclusion criteria were selected for this review.RESULTS: The included studies were characterized by the heterogeneity on the scales used to measure pain and pre-operative factors related to PPSP and NP. The reported prevalence of PPSP and NP seems to be relatively high, but it varies among different studies. There is also evidence that the prevalence of post-surgical pain is related to the scale used for pain measurement. The prevalence of PPSP is ranging at 6 mo from 16% to 39% and at 12 mo from 13.1% to 23% and even 38% of the patients. The prevalence of NP at 6 mo post-operatively is ranging from 5.2% to13%. Pre-operative factors related to the development of PPSP also differ, including emotional functioning, such as depression and pain catastrophizing, number of comorbidities, pain problems elsewhere and operations in knees with early grade of osteoarthritis.CONCLUSION: No firm conclusions can be reached regarding the prevalence of PPSP and NP and the related factors due to the heterogeneity of the studies. | Georgios I Drosos Triantafilia Triantafilidou Athanasios Ververidis Cristina Agelopoulou Theodosia Vogiatzaki Konstantinos Kazakos | 2015 | World Journal of Orthopedics2015，6，7： | 6 |
| 4 | 秸秆生物质炭DOM光谱特征及其与Cu^(2+)的相互作用显示文摘通过荧光猝灭滴定法探究玉米秸秆炭(MSB)、水稻秸秆炭(RSB)和花生秸秆炭(PSB)中DOM的光谱特征及其与Cu^(2+)的络合机理.结果表明:三种生物质炭的DOM均具有较高的亲水性和较低的芳香性,其中RSB-DOM的芳香性相对较强、分子量较大,但DOM含量低,PSB-DOM含量最高,芳香结构中含氧官能团较多.MSB和RSB-DOM中均含类富里酸组分C1和类腐殖酸组分C3、C4,RSB-DOM中还有类色氨酸组分C5,PSB-DOM则由两种类富里酸组分C1、C2和较长波长类腐殖酸组分C4组成,3种DOM均以类富里酸组分为主,占比达54.93%~86.29%.Cu^(2+)与类腐殖酸组分的稳定常数(logK_M)高于类富里酸组分,且类腐殖酸组分C4的络合能力(f)最强,类腐殖酸组分的logK_M和f值总体上表现为:PSB-DOM>MSB-DOM>RSB-DOM.二维相关光谱分析发现,类富里酸组分对Cu^(2+)最敏感,而Cu^(2+)优先与类腐殖酸组分结合.研究结果有助于进一步揭示生物质炭的DOM对Cu^(2+)环境行为的影响机制. | 李婉秋 施暖暖 Marios Drosos 李恋卿 潘根兴 | 2021 | 中国环境科学2021，41，8： | 5 |
| 5 | Use of demineralized bone matrix in the extremities显示文摘Autologous bone graft is considered as the gold standard for all indications for bone grafting procedures but the limited availability and complications in donor site resulted in seeking other options like allografts andbone graft substitutes. Demineralized bone matrix(DBM) is an allograft product with no quantity limitation. It is an osteoconductive material with osteoinductive capabilities, which vary among different products, depending on donor characteristics and differences in processing of the bone. The purpose of the present review is to provide a critical review of the existing literature concerning the use of DBM products in various procedures in the extremities. Clinical studies describing the use of DBM alone or in combination with other grafting material are available for only a few commercial products. The Level of Evidence of these studies and the resulting Grades of Recommendation are very low. In conclusion, further clinical studies of higher quality are required in order to improve the Recommendation Grades for or against the use of DBM products in bone grafting procedures. | Georgios I Drosos Panagiotis Touzopoulos Athanasios Ververidis Konstantinos Tilkeridis Konstantinos Kazakos | 2015 | World Journal of Orthopedics2015，6，2： | 4 |
| 6 | Use of demineralized bone matrix in spinal fusion显示文摘Spinal fusion remains the gold-standard treatment for several pathological spine conditions. Although, autologous Iliac Crest Bone Grafting is considered the goldstandard graft choice to promote spinal fusion; however, it is associated with significant donor site morbidity and a limited graft quantity. Therefore, several bone graft alternatives have been developed, to augment arthrodesis. The purpose of this review is to present the results of clinical studies concerning the use of demineralized bone matrix(DBM), alone or as a composite graft, in the spinal fusion. A critical review of the English-language literature was conducted on Pubmed, using key word 'demineralized bone matrix', 'DBM', 'spinal fusion', and 'scoliosis'. Results had been restricted to clinical studies. The majority of clinical trials demonstrate satisfactory fusion rates when DBM is employed as a graft extender or a graft enhancer.Limited number of prospective randomized controlled trials(4 studies), have been performed comparing DBM to autologous iliac crest bone graft in spine fusion. The majority of the clinical trials demonstrate comparable efficacy of DBM when it used as a graft extender in combination with autograft, but there is no clinical evidence to support its use as a standalone graft material. Additionally, high level of evidence studies are required, in order to optimize and clarify the indications of its use and the appropriate patient population that will benefit from DBM in spine arthrodesis. | Konstantinos Tilkeridis Panagiotis Touzopoulos Athanasios Ververidis Sotirios Christodoulou Konstantinos Kazakos Georgios I Drosos | 2014 | World Journal of Orthopedics2014，5，1： | 4 |
| 7 | Behaviour of deep immersed tunnel under combined normal fault rupture deformation and subsequent seismic shaking显示文摘 | Ioannis Anastasopoulos Nikos Gerolymos Vasileios Drosos Takis Georgarakos Rallis Kourkoulis George Gazetas | 2008 | Bulletin of Earthquake Engineering2008，，2： | 2 |
| 8 | 宁镇丘陵区村域小流域不同土壤景观下表土质量变化及评价显示文摘中国南方丘陵区存在着自然过程和人类活动交互影响的、土地利用—土地覆盖叠加变化的多种土壤景观,其土壤质量对乡村农业产业发展具有重要影响。在南京市远郊的溧水区晶桥镇芝山村域小流域,选取流域内生态保护的林地、农业利用的园地、旱地和稻田4种土壤景观,于秋季分别采集表土样品,测定土壤基础理化性质、土壤团聚体粒径组成及土壤微生物磷脂肪酸和胞外酶活性分布,分析土壤肥力、土壤团聚化、土壤生物活性等关键性质在不同土壤景观中的变异情况,并采用土壤质量评价方法探明土壤景观与表土质量的变化关系。结果表明,与原生林地相比,农业土壤景观中有机质减少50.93%~69.63%,土壤团聚体平均重量直径降低41.34%~68.71%;相应地,土壤微生物总磷脂脂肪酸含量也降低19.20%~42.04%,土壤归一化酶活性降低22.48%~63.27%。因此,与林地景观土壤相比,农业土壤景观的土壤生态系统服务功能已经显著削弱。不过,在农业土壤景观中,稻田的土壤有机质储量和微生物活性相对较高。回归分析表明,土壤有机质含量是影响土壤性质变化的最强因子。基于总数据集和最小数据集的土壤质量评价和基于土壤健康理念的土壤功能质量评价均表明,表土总体土壤质量的变化趋势为林地>稻田>旱地>园地。同时,基于土壤健康理念的评价体系能综合地反映不同土壤景观间土壤的质量变化及其生态系统功能意义。 | 赵正 刘纯 尚明月 陈敬龙 包旭华 刘晓雨 卞荣军 张旭辉 程琨 王燕 Drosos Marios 郑聚锋 李恋卿 潘根兴 | 2022 | 水土保持学报2022，36，4： | 2 |
| 9 | Measuring the Accuracy and Precision of the Garmin GPS Positioning in Forested Areas: A Case Study in Taxiarchis-Vrastama University Forest显示文摘 | Vasileios C. Drosos Chrisvaladis Malesios | 2012 | Journal of Environmental Science and Engineering(B)2012，1，4： | 2 |
| 10 | Behaviour of deep immersed tunnel under combined normal fault rupture deformation and subsequent seismic shaking显示文摘 | Ioannis Anastasopoulos Nikos Gerolymos Vasileios Drosos Takis Georgarakos Rallis Kourkoulis George Gazetas | 2008 | Bulletin of Earthquake Engineering2008，，2： | 2 |
| 11 | Hepatitis C in human immunodeficiency virus co-infected individuals: Is this still a “special population”?显示文摘A substantial proportion of individuals with chronic hepatitis C virus(HCV) are co-infected with human immunodeficiency virus(HIV). Co-infected individuals are traditionally considered as one of the 'special populations' amongst those with chronic HCV, mainly because of faster progression to end-stage liver disease and suboptimal responses to treatment with pegylated interferon alpha and ribavirin, the benefits of which are often outweighed by toxicity. The advent of the newer direct acting antivirals(DAAs) has given hope that the majority of co-infected individuals can clear HCV. However the 'special population' designation may prove an obstacle for those with co-infection to gain access to the new agents, in terms of requirement for separate pre-licensing clinical trials and extensive drug-drug interaction studies. We review the global epidemiology, natural history and pathogenesis of chronic hepatitis C in HIV co-infection. The accelerated course of chronic hepatitis C in HIV co-infection is not adequately offset by successful combination antiretroviral therapy. We also review the treatment trials of chronic hepatitis C in HIV co-infected individuals with DAAs and compare them to trials in the HCV mono-infected. There is convincing evidence that HIV co-infection no longer diminishes the response to treatment against HCV in the new era of DAA-based therapy. The management of HCV co-infection should therefore become a priority in the care of HIV infected individuals, along with public health efforts to prevent new HCV infections, focusing particularly on specific patient groups at risk, such as men who have sex with men and injecting drug users. | Drosos E Karageorgopoulos Joanna Allen Sanjay Bhagani | 2015 | World Journal of Hepatology2015，7，15： | 2 |
| 12 | Tigecyeline for the Treatment of Mul- tidrug Resisdant (Including Carbapeneu Resistant) Acineto- baeter Infections: A Review of Scientific Evidence显示文摘 | Drosos E Theodore K | 2008 | J Amti- mierob Chemother2008，62，： | 1 |
| 13 | Nonlinear response of deep immersed tunnel to strong seismic shaking 显示文摘 | Anastasopoulos I Gerolymos N Drosos V | 2007 | Journal of Geotechnical and Geoenvironmental Engineering2007，133，9： | 1 |
| 14 | Vacuum-assisted closure downgrades reconstructive demands in high-risk patients with severe lower extremity injuries显示文摘 | Kakagia D Karadimas E Drosos G | 2009 | Acta Chir Plast2009，51，34： | 1 |
| 15 | Incidence and prevalence of rheumatoid arthritis,based on the 1987 American College of Rheumatology criteria:asystematic review显示文摘 | Alamanos Y Voulgari P Drosos A | 2006 | Semin Arthritis Rheum2006，36，3： | 1 |
| 16 | Factors affect-ing fracture healing after intramedullary nailing of thetibial diaphysis for closed and grade I open fractures显示文摘 | Drosos GI Bishay M Karnezis IA | 2007 | J Bone Joint Surg Br2007，88，2： | 1 |
| 17 | Factors affecting fracture healing after intramedultary nailing of thetibial diaphysis for closed and grade I open fractures 显示文摘 | Drosos GI Bishay M Karnezis IA | 2006 | J Bone Joint Surg Br2006，88，2： | 1 |
| 18 | Mechanical characterization of bone graft substitute ce- ramic cements显示文摘 | Drosos GI Babourda E Magnissalis EA | 2012 | Iniury2012，43，3： | 1 |
| 19 | Imaging of thoracic Wegener's granulomatosis:the computed tomographic appearance显示文摘 | Papiris SA Manoussakis MN Drosos AA | 1992 | AM J Med1992，93，5： | 1 |
| 20 | The spectrum ofneurological involvement in Sjogren,s syndrome显示文摘 | Andonopoulos AP Lagos G Drosos AA et ai | 1999 | Brit JRheumatol1999，29，： | 1 |
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