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| 1 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 2 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 3 | Geology and structural evolution of the Muruntau gold deposit, Kyzylkum Desert, Uzbekistan 显示文摘 | Berger B R Kurbanov N K | 1996 | Ore Geology Reviews1996，11，： | 1 |
| 4 | Glueagon - like peptide - 1 promotes satiety and reduces food in take in patients with diabetes mellitus type 2 显示文摘 | Gutzwiller JP Drewe J Goke B | 1999 | Am J Physiol Regul lntegr Comp Physiol1999，276，： | 1 |
| 5 | Rapid determination of particle velocity from space-time images using the Radon transform 显示文摘 | Drew P J Pablo B Gert C | 2010 | Journal of Computational Neuro- science2010，29，1： | 1 |
| 6 | Carbon diox- ide capture using ionic liquid 1-butyl-3-methylimidazolium acetate 显示文摘 | Shiflett M B Drew D W Cantini R A | 2010 | Energy & Fuels2010，24，10： | 1 |
| 7 | The development of improved dairy cow feeding strategies to enhance the contentand composition of milk fat显示文摘 | Drew B | 1999 | Agriculture-Food-Industry Hi-Technology Nov/Dec1999，912，： | 1 |
| 8 | Boundary slip in Newtonian liquids : a review of experimental studies 显示文摘 | CHIARA N DREW R E ELMAR B | 2005 | Reports on Progress in Physics2005，61，12： | 1 |
| 9 | A cellulose-hydrolyzing factor in aphid saliva显示文摘 | Adams J B Drew M E | 1965 | Can J Zool1965，43，： | 1 |
| 10 | Complexes formed between the quadridentate,heterocyclic molecules 6,6′-bis-(5,6-dialkyl-1,2,4-triazin-3-yl)-2,2′-bipyridine(BTBP) and lanthanides(III):implications for the partitioning of actinides(III) and lanthanides(III)显示文摘 | Foreman M R Hudson M J Drew M G B | | 0，，13： | 1 |
| 11 | Practice standards for ECG monito-ring in hospital settings : executive summary and guidefor implementation显示文摘 | Drew B J Funk M | 2006 | Crit Care Nurs Clin North Am2006，18，15： | 1 |
| 12 | Genes downstream from pucB and pucA are essential for formation of the B800-850 complex of Rhodobacter capsulatus 显示文摘 | Tichy HV Oberlé B Stiehle H Schiltz E Drews G | 1989 | J Bacteriol1989，171，： | 1 |
| 13 | Influence of alloying el-ments on steel strength显示文摘 | Frommeyer G Drewes E J Engl B | 2000 | Rev Metall2000，10，2： | 1 |
| 14 | Complexes formed between the quadridentate, heterocyclic molecules 6, 6' bis-(5, 6- diaikyl-1, 2, 4-triazin-3-yl )-2, 2'-bipyridine (BTBP) and lanthanides ( Ⅲ ) : Implications for the partitioning of actnides( Ⅲ) and lanthanides (Ⅲ)显示文摘 | FOREMAN M R HUDSON M J DREW M G B | 2006 | Dalton Transactions2006，13，： | 1 |
| 15 | Regulationof BCRP(ABCG2)and P-glycoprotein(ABCB1)bycytokines in a model of the human blood-brain barri-er显示文摘 | Poller B Drewe J Krahenbuhl S | 2010 | Cell Mol Neurobiol2010，30，1： | 1 |
| 16 | Comparison of Extraction Behaviour and Basicity of some Substituted Malonamides显示文摘 | Spjuth L Liljenzin J O Hudson M I Drew M G B Iveson P B Madic C | 2000 | Solvent Extr Ion Exch2000，18，1： | 1 |
| 17 | Transcriptional and posttranscriptional regulation of soybean seed protein mRNA Level显示文摘 | Walling L Drews G N Goldberg R B | 1986 | Proc Natl Acad sci1986，83，： | 1 |
| 18 | Seasonal phenology of Bactrocera minax (Diptera:Tephritidae) in western Bhutan显示文摘 | Dorji C Clark A R Drew R A I Fletcher B S Loday P Mahat K Raghu S and Roming M C | | 0，，： | 1 |
| 19 | Diagnostic accuracy of magnetic resonance imaging and magnetic resonance arthrogra- phy for triangular fibrocartilaginous complex injury: a systemat- ic review and recta-analysis显示文摘 | Smith T O Drew B Toms A P | 2012 | J Bone Joint Surg Am2012，94，9： | 1 |
| 20 | The extended latissimus dorsi flap in repair of anterior abdominal wall defects 显示文摘 | Houston GC Drew GS Vazquez B | 1988 | Plast Reconstr Surg1988，81，6： | 1 |
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