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| 1 | How to protect liver graft with nitric oxide显示文摘Organ preservation and ischemia reperfusion injury as- sociated with liver transplantation play an important role in the induction of graft injury. One of the earliest events associated with the reperfusion injury is en- dothelial cell dysfunction. It is generally accepted that endothelial nitric oxide synthase (e-NOS) is cell-pro- tective by mediating vasodilatation, whereas inducible nitric oxide synthase mediates liver graft injury after transplantation. We conducted a critical review of the literature evaluating the potential applications of regu- lating and promoting e-NOS activity in liver preservation and transplantation, showing the most current evidenceto support the concept that enhanced bioavailability of NO derived from e-NOS is detrimental to ameliorate graft liver preservation, as well as preventing subse- quent graft reperfusion injury. This review deals mainly with the beneficial effects of promoting 'endogenous' pathways for NO generation, via e-NOS inducer drugs in cold preservation solution, surgical strategies such as ischemic preconditioning, and alternative 'exogenous' pathways that focus on the enrichment of cold storage liquid with NO donors. Finally, we also provide a basic bench-to-bed side summary of the liver physiology and cell signalling mechanisms that account for explaining the e-NOS protective effects in liver preservation and transplantation. ? 2011 Baishideng. All rights reserved. | Hassen Ben Abdennebi Mohamed Amine Zaoualí Izabel Alfany-Fernandez Donia Tabka Joan Roselló-Catafau | 2011 | World Journal of Gastroenterology2011，17，24： | 10 |
| 2 | Effects of Institut Georges Lopez-1 and Celsior preservation solutions on liver graft injury显示文摘AIM: To compare Institut Georges Lopez(IGL-1) and Celsior preservation solutions for hepatic endothelium relaxation and liver cold ischemia reperfusion injury(IRI).METHODS: Two experimental models were used.In the first one, acetylcholine-induced endotheliumdependent relaxation(EDR) was measured in isolated ring preparations of rat hepatic arteries preserved or not in IGL-1 or Celsior solutions(24 h at 4 ℃).To determine nitric oxide(NO) and cyclooxygenase EDR, hepatic arteries were incubated with L-NG-nitroarginine methyl ester(L-NAME), an inhibitor of endothelium nitric oxide synthase(e NOS), or with L-NAME plus indomethacin, an inhibitor of cyclooxygenase.In the second experiment, rat livers were cold-stored in IGL-1 or Celsior solutions for 24 h at 4 ℃ and then perfused 'ex vivo ' for 2 h at 37 ℃.Liver injury was assessed by transaminase measurements, liver function by bile production and bromosulfophthalein clearance, oxidative stress by malondialdehyde levels and catalase activity and alterations in cell signaling pathways by pA kt, pA MPK, eN OS and MAPKs proteins level.RESULTS: After cold storage for 24 h with either Celsior or IGL-1, EDR was only slightly altered.Infreshly isolated arteries, EDR was exclusively mediated by NO.However, cold-stored arteries showed NOand COX-dependent relaxation.The decrease in NO-dependent relaxation after cold storage was significantly more marked with Celsior.The second study indicated that IGL-1 solution obtained better liver preservation and protection against IRI than Celsior.Liver injury was reduced, function was improved and there was less oxidative stress.IGL-1 solution activated Akt and AMPK, which was concomitant with increased eN OS expression and nitrite/nitrate levels.Furthermore, MAPKs kinases were regulated in livers preserved with IGL-1 solution since reductions in p-p38, p-ERK and p-JNK protein levels were observed.CONCLUSION: IGL-1 solution preserved NO-dependent relaxation better than Celsior storage solution and enhanced liver graft preservation. | Donia Tabka Mohamed Bejaoui James Javellaud Joan Roselló-Catafau Jean-Michel Achard Hassen Ben Abdennebi | 2015 | World Journal of Gastroenterology2015，21，14： | 6 |
| 3 | Self-compatibility in peach[Prunus persica(L.)Batsch]:patterns of diversity surrounding the S-locus and analysis of SFB alleles显示文摘Self-incompatibility(SI)to self-compatibility(SC)transition is one of the most frequent and prevalent evolutionary shifts in flowering plants.Prunus L.(Rosaceae)is a genus of over 200 species most of which exhibit a Gametophytic SI system.Peach[Prunus persica(L.)Batsch;2n=16]is one of the few exceptions in the genus known to be a fully selfcompatible species.However,the evolutionary process of the complete and irreversible loss of SI in peach is not well understood and,in order to fill that gap,in this study 24 peach accessions were analyzed.Pollen tube growth was controlled in self-pollinated flowers to verify their self-compatible phenotypes.The linkage disequilibrium association between alleles at the S-locus and linked markers at the end of the sixth linkage group was not significant(P>0.05),except with the closest markers suggesting the absence of a signature of negative frequency dependent selection at the S-locus.Analysis of SFB1 and SFB2 protein sequences allowed identifying the absence of some variable and hypervariable domains and the presence of additionalα-helices at the C-termini.Molecular and evolutionary analysis of SFB nucleotide sequences showed a signature of purifying selection in SFB2,while the SFB1 seemed to evolve neutrally.Thus,our results show that the SFB2 allele diversified after P.persica and P.dulcis(almond)divergence,a period which is characterized by an important bottleneck,while SFB1 diversified at a transition time between the bottleneck and population expansion. | Donia Abdallah Ghada Baraket Veronica Perez Amel Salhi Hannachi Jose I.Hormaza | 2020 | Horticulture Research2020，7，1： | 3 |
| 4 | Studies on uptake behaviour of copper(II) and lead(II) by amine chelating resins with different textural properties显示文摘 | Asem A Atia Ahmed M Donia Saeda A Abou-El-Enein Ahmed M Yousif | 2003 | Separation and Purification Technology2003，，3： | 2 |
| 5 | Training program for caregivers to prevent pressure ulcers among elderly residents at geriatric homes显示文摘Objectives:Pressure ulcer(PU)is one of the most common problem among the bedridden elderly and has significantly more burden on elderly and caregivers.This study is aimed to evaluate the effects of the training program for caregivers to prevent PUs among elderly residents at geriatric homes.Methods:A quasi-experimental design was used to carry out the current study.A purposive sample comprised of all formal(39 nurses)or informal caregivers(39)and all immobilized elderly residents(35)who are found in all geriatric centers in Helwan district.A structured questionnaire was used to assess caregivers’socio-demographic characteristics,knowledge,attitude,and observational checklists for their practice for prevention of PU at pre-and posttest and during follow-up.Results:After the training program,there were improvements in the level of knowledge,practice,and positive attitude of caregivers about PU prevention with a statistically significant difference between pre-,post-,and follow-up training programs(P<0.001).Conclusions:The study revealed that the training program seemed to change the knowledge,practice,and attitude of the subjects to PU prevention.This,in turn,implies that adequate knowledge affects directly the elderly caregivers’attitudes as well as practice for prevention could be important in reducing the burden of PU among the elderly.Thus,conducting a training program for caregivers at different geriatric homes about caring skills for elders can prevent PU,and using spontaneous reposition is very effective to prevent PUs. | Donia Atef Ibrahiem Mona Mohamed Abd El-Maksoud | 2021 | Frontiers of Nursing2021，8，3： | 2 |
| 6 | Marine natural products and their potential applications as anti-infective agents显示文摘 | Marwa Donia Mark T Hamann | 2003 | The Lancet Infectious Diseases2003，，6： | 2 |
| 7 | Photocatalytic oxidation of organics in water using pure and silver-modifiedtitanium dioxide particles 显示文摘 | Veronica V Rose A Donia B | 2002 | Journal of Photochemistry and Photobiology A: Chemistry2002，148，： | 1 |
| 8 | Recovery of gold(liD and silver(I) on a chemically modified chitosan with magnetic prop- erties显示文摘 | Donia A M Atia A A Elwakeel K Z | 2007 | Hydrometallurgy2007，87，： | 1 |
| 9 | The realistie downsizing preview: a multiple case study, partl: the methodology and results of data collection 显示文摘 | Appelbaum S H Donia M | 2001 | Career Development International2001，，6： | 1 |
| 10 | 显示文摘 | Sarah S W Donia B Jason A S | 2003 | Chemical Engi- neering Journal2003，95，1： | 1 |
| 11 | Selective separation of mercury(Ⅱ)using a synthetic resin containing amine and mercaptan as chelating groups显示文摘 | Asem A Atia Ahmed M Donia Khalid Z Elwakeel | 2005 | Reactive&Functional Polymers2005，65，3： | 1 |
| 12 | Comparative study on the recovery of silver ( Ⅰ ) from aqueous solutions using different chelating resins derived from glycidyl methacrylate 显示文摘 | Atia A A Donia A M Yousif A M | 2005 | Journal of Applied Polymer Science2005，97，3： | 1 |
| 13 | REVIEW: fast- tracking cardiac surgery 显示文摘 | Pande RU Nader ND Donias HW | 2003 | Heart Surg Forum2003，6，4： | 1 |
| 14 | Obstructive sleep apnea and cause of dysrhythmia in sudden cardiac death显示文摘 | Szaboova E Donia V TomoriZ | 1997 | Bratisl Lek Listy1997，98，4： | 1 |
| 15 | Gold( Ⅲ ) recovery using synthetic chelating resins with amine, thio and amine/mercaptan functionalities 显示文摘 | Donia A M Atia A A Elwakeel K Z | 2005 | Separation and Purification Technology2005，42，： | 1 |
| 16 | Removal of some hazardous heavy metals from aqueous solution using magnetic chelating resin with iminodiacetate functionality 显示文摘 | Asem A Aria Ahmed M Donia Ahmed M Yousif | 2008 | Separation and Purification Technology2008，61，3： | 1 |
| 17 | Human bocavirus in children with acute gastroenteritis in Albania显示文摘 | G. La Rosa S. Della Libera M. Iaconelli D. Donia F. Cenko G. Xhelilaj P. Cozza M. Divizia | 2016 | J. Med. Virol2016，，： | 1 |
| 18 | A synthesis of progesterone from ergosterol显示文摘 | Shepherd DA Donia RA Ott AC | 1955 | JAmer Chem Soc1955，77，： | 1 |
| 19 | Selective separation of mercury ( II ) using magnetic chitosan resin modified with Schiff's base derived from thiourea and glutaraldehyde显示文摘 | Donia A Atia A Elwakeel K | 2008 | Journal of Hazardous Materials2008，151，23： | 1 |
| 20 | Lateral hypothalamic NMDA receptors and glutamate as physiological mediators of eating and weight control显示文摘 | Stanley BG Willett VL Donias HW | 1996 | Am J Physiol1996，270，2： | 1 |
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