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| 1 | A NAC transcription factor, NOR-like1, is a new positive regulator of tomato fruit ripening显示文摘Ripening of the model fruit tomato(Solanum lycopersicum)is controlled by a transcription factor network including NAC(NAM,ATAF1/2,and CUC2)domain proteins such as No-ripening(NOR),SlNAC1,and SlNAC4,but very little is known about the NAC targets or how they regulate ripening.Here,we conducted a systematic search of fruit-expressed NAC genes and showed that silencing NOR-like1(Solyc07g063420)using virus-induced gene silencing(VIGS)inhibited specific aspects of ripening.Ripening initiation was delayed by 14 days when NOR-like1 function was inactivated by CRISPR/Cas9 and fruits showed obviously reduced ethylene production,retarded softening and chlorophyll loss,and reduced lycopene accumulation.RNA-sequencing profiling and gene promoter analysis suggested that genes involved in ethylene biosynthesis(SlACS2,SlACS4),color formation(SlGgpps2,SlSGR1),and cell wall metabolism(SlPG2a,SlPL,SlCEL2,and SlEXP1)are direct targets of NOR-like1.Electrophoretic mobility shift assays(EMSA),chromatin immunoprecipitation-quantitative PCR(ChIP-qPCR),and dual-luciferase reporter assay(DLR)confirmed that NOR-like1 bound to the promoters of these genes both in vitro and in vivo,and activated their expression.Our findings demonstrate that NOR-like1 is a new positive regulator of tomato fruit ripening,with an important role in the transcriptional regulatory network. | Ying Gao Wei Wei Xiaodan Zhao Xiaoli Tan Zhongqi Fan Yiping Zhang Yuan Jing Lanhuan Meng Benzhong Zhu Hongliang Zhu Jianye Chen Cai-Zhong Jiang Donald Grierson Yunbo Luo Da-Qi Fu | 2018 | Horticulture Research2018，5，1： | 9 |
| 2 | Capecitabine with radiation is an effective adjuvant therapy in gastric cancers显示文摘AIM:To analyze the outcome of patients who received concurrent capecitabine(Xeloda) and radiation(XRT) compared to the established concurrent 5-fluorouracil(5-FU) with radiation(5FU-RT) and fluoropyrimidine-based chemotherapy alone as adjuvant treatment in gastric cancers.METHODS:All patients with gastric cancers who received adjuvant treatment at the National Cancer Centre Singapore between 1996 and 2006 were reviewed.Treatment outcomes of patients who received XRT were compared with those who had 5FU-RT or chemotherapy alone as adjuvant therapy for gastric cancers.RESULTS:A total of 108 patients were reviewed.Median age at diagnosis was 60.The majority of the patients(64.8%) had advanced stage Ⅲ and Ⅳ disease(with no distant metastasis).All except 4 patients had D2 gastrectomy.Twenty one patients(19.4%) had positive surgical resection margins.Thirty three patients received XRT compared with 52 who had 5FU-RT and 23 who received chemotherapy alone.For the patients in the chemotherapy-only group,all had fluoropyrimidine-based therapy,with added cisplatin in 7 patients and epirubicin in 2 patients.Median recurrence-free survival was longer for the XRT group(52 mo) compared to the 5FU-RT(35 mo) and chemotherapy-only groups(25 mo)(P=0.48).The patients in the XRT group achieved similar median overall survival(53 mo) as the 5FU-RT(54 mo) and the chemotherapy-only groups(44 mo)(P=0.5).CONCLUSION:Capecitabine with concurrent radiation was as effective as concurrent 5FU with radiation or fluoropyrimidine-based chemotherapy alone when used as adjuvant treatment in patients with gastric cancers. | Chee Kian Tham Su Pin Choo Donald Yew Hee Poon Han Chong Toh Simon Yew Kuang Ong Sze Huey Tan Michael Lian Chek Wang Kian Fong Foo | 2010 | World Journal of Gastroenterology2010，16，29： | 6 |
| 3 | Atropine for the Treatment of Childhood Myopia显示文摘 | Wei-Han Chua Vivian Balakrishnan Yiong-Huak Chan Louis Tong Yvonne Ling Boon-Long Quah Donald Tan | 2006 | Ophthalmology2006，，12： | 2 |
| 4 | A 10-Year Prospective Audit of LASIK Outcomes for Myopia in 37<ce:hsp sp='0.25'/>932 Eyes at a Single Institution in Asia显示文摘 | Leonard H. Yuen Wing Kwong Chan Jane Koh Jodhbir S. Mehta Donald T. Tan | 2010 | Ophthalmology2010，，6： | 1 |
| 5 | Mast cell deficiency attenuates progression of atherosclerosis and hepatic steatosis in apolipoprotein E-null mice显示文摘 | Donald D. Smith Xiaoyu Tan Vineesh V. Raveendran Ossama Tawfik Daniel J. Stechschulte Kottarappat N. Dileepan | 2012 | AJP: Heart and Circulatory Physiology2012，，12： | 1 |
| 6 | Corneal transplantation显示文摘 | Donald TH Tan John KG Dart Edward J Holland Shigeru Kinoshita | 2012 | The Lancet2012，，9827： | 1 |
| 7 | Endothelial Keratoplasty: A Revolution in Evolution显示文摘 | Arundhati Anshu Marianne O. Price Donald T.H. Tan Francis W. Price | 2012 | Survey of Ophthalmology2012，，3： | 1 |
| 8 | Optimal impedance termination of 25 kV electrified railway systems for improved power quality显示文摘 | Tan Pee-Chin Loh Poh Chiang Holmes Donald Grahame | 2005 | IEEE Trans on Power Delivery2005，20，2： | 1 |
| 9 | Molecular charzcterization Arabidopsis 9-cisepoxycaotenoid dioxygenase gene family显示文摘 | BAO-CAI TAN LEINA M J WEN-TAO D LIGUAN L KENNETH C DONALD R M | 2003 | The Plant Journal2003，35，： | 1 |
| 10 | Prevalence of Age-Related Macular Degeneration in a Malay Population显示文摘 | Ryo Kawasaki Jie Jin Wang Tin Aung Donald T.H. Tan Paul Mitchell Mya Sandar Seang-Mei Saw Tien Y. Wong | 2008 | Ophthalmology2008，，10： | 1 |
| 11 | A robust multilevel hybrid compensation system for 25-kV electrified railway Applications 显示文摘 | Tan Pee-Chin Loh Poh Chiang Holmes Donald Grahame | 2004 | IEEE Trans on Power Electronics2004，19，4： | 1 |
| 12 | Expression of p63 in pterygium and normal conjunctiva显示文摘 | Pompilas Sakoonwatanyoo Donald TH Tan Duncan R Smith | 2004 | Cornea2004，23，1： | 1 |
| 13 | The in vitro and in vivo proliferative capacity of serum-free cultivated human conjunctival epithelial cells显示文摘 | Leonard P.K. Ang Donald T.H. Tan Toan Thang Phan Jing Li Roger Beuerman Robert M. Lavker | 2004 | Current Eye Research2004，，5： | 1 |
| 14 | Optimal impedance termination of 25-kV electrified railway systems for improved power quality显示文摘 | Tan Pee-Chin Loh Poh Chiang Holmes Donald Grahame | 2005 | IEEE Trans on Power Delivery2005，20，2： | 1 |
| 15 | Ocular surface changes in pterygium显示文摘 | Cordelia ML Chan Yan Ping Liu Donald TH Tan | 2002 | Cornea2002，21，1： | 1 |
| 16 | Interventions to retard myopia progression in children显示文摘 | Seang-Mei Saw Edwin Chan Shih-Yen Adrian Koh Donald Tan | 2002 | Ophthalmology2002，，3： | 1 |
| 17 | Suppression of TGF-? signaling in both normal conjunctival fibroblasts and pterygial body fibroblasts by amniotic membrane显示文摘 | Sao-Bing Lee De-Quan Li Donald T.H. Tan Daniel Meller Scheffer C.G. Tseng | 2000 | Current Eye Research2000，，4： | 1 |
| 18 | Optimal impedance termination of 25-kV electrified railway systems for improved power quali- ty显示文摘 | Tan Pee-Chin Loh Poh Chiang Holmes Donald Grahame | 2005 | IEEE Trans on Power Delivery2005，20，2： | 1 |
| 19 | Current concepts and techniques in pterygium treatment显示文摘 | Leonard PK Ang Jocelyn LL Chua Donald TH Tan | 2007 | Current Opinion in Ophthalmology2007，，4： | 1 |
| 20 | Corneal transplantation显示文摘 | Donald TH Tan John KG Dart Edward J Holland Shigeru Kinoshita | 2012 | The Lancet2012，，9827： | 1 |
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