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| 1 | Noninvasive assessment of liver damage in chronic hepatitis B显示文摘AIM:To evaluate the efficacy of the aspartate aminotransferase/platelet ratio index(APRI)and neutrophillymphocyte(N/L)ratio to predict liver damage in chronic hepatitis B(CHB).METHODS:We analyzed 89 patients diagnosed with CHB by percutaneous liver biopsy and 43 healthy subjects.Liver biopsy materials were stained with hematoxylin-eosin and Masson’s trichrome.Patients’fibrosis scores and histological activity index(HAI)were calculated according to the Ishak scoring system.Fibrosis score was recognized as follows:F0-1 No/early-stage fibrosis,F2-6 significant fibrosis,F0-4 non-cirrhotic and F5-6 cirrhotic.Significant liver fibrosis was defined as an Ishak score of≥2.APRI and N/L ratio calculation was made by blood test results.RESULTS:The hepatitis B and control group showed no difference in N/L ratios while there was a significant difference in terms of APRI scores(P<0.001).Multiple logistic regression analysis revealed that the only independent predictive factor for liver fibrosis in CHB was platelet count.APRI score was significantly higher in cirrhotic patients than in non-cirrhotic patients.However,this significance was not confirmed by multiple logistic regression analysis.The optimum APRI score cut-off point to identify patients with cirrhosis was 1.01with sensitivity,specificity,positive predictive value and negative predictive value of 62%(36%-86%),74%(62%-83%),29%(13%-49%)and 92%(82%-97%),respectively.In addition,correlation analyses revealed that N/L ratio has a negative and significant relationship with HAI(r=-0.218,P=0.041).CONCLUSION:N/L ratio was negatively correlated with HAI.APRI score may be useful to exclude cirrhosis in CHB patients. | Mehmet Celikbilek Serkan Dogan Sebnem Gursoy Gokmen Zararsιz Alper Yurci Omer Ozbakιr Kadri Guven Mehmet Yucesoy | 2013 | World Journal of Hepatology2013，5，8： | 5 |
| 2 | Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps显示文摘AIM:To determine,by counting micronucleus (MN) frequencies,whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). METHODS:We analyzed MN frequencies in 21 patients with CRC,24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls. RESULTS:MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 ± 1.34,3.58 ± 1.21 vs 1.97 ± 0.81,P < 0.001). However,there was no difference in the MN frequency between CRC patients and NP patients (P > 0.05). Similarly,there was no difference in the MN frequency between NNP patients (2.06 ± 0.85) and controls (P > 0.05). CONCLUSION:Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC. | Ali Karaman Dogan Nas■r Binici Mehmet E■ref Kabalar Züleyha ■al■ku■u | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 3 | β-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas:role in the regulation of response to somatostatin analogue treatment in patients with acromegaly显示文摘Recent in vitro studies highlighted G protein-coupled receptor kinase(GRK)2 andβ-arrestins as important players in driving somatostatin receptor(SSTR)desensitization and trafficking.Our aim was to characterize GRK2 andβ-arrestins expression in different pituitary adenomas and to investigate their potential role in the response to somatostatin analog(SSA)treatment in GHsecreting adenomas(GHomas).We evaluated mRNA expression of multiple SSTRs,GRK2,β-arrestin 1,andβ-arrestin 2 in 41pituitary adenomas(31 GHomas,6 nonfunctioning[NFPAs],and 4 prolactinomas[PRLomas]).Within the GHomas group,mRNA data were correlated with the in vivo response to an acute octreotide test and with the GH-lowering effect of SSA in cultured primary cells.β-Arrestin 1 expression was low in all 3 adenoma histotypes.However,its expression was significantly lower in GHomas | Gatto F Feelders R van der Pas R Kros JM Dogan F van Koetsveld PM van der Lelij AJ Neggers SJ Minuto F de Herder W Lamberts SW Ferone D Hofland LJ | 2013 | 中国神经肿瘤杂志2013，11，4： | 2 |
| 4 | Composite Piezoelectric Transducer with Truncated Conical Endcaps Cymba显示文摘 | Dogan A Uchino K Newnham R E | 1997 | IEEE Transactins on Ultrasonics Ferro- electroines and Frequency Control1997，44，3： | 1 |
| 5 | Vascular anomalies causing tracheoesophageal compression: a 20-year experience in diagnosis and management 显示文摘 | Yilmaz M Ozkan M Dogan R | 2003 | The Heart Surg Forum2003，6，3： | 1 |
| 6 | Vascular anomalies causing tracheoesophageal compression:a 20 year experience in diagnosis and management显示文摘 | Yilmaz M Ozkan M Dogan R | 2003 | Heart Surg Forum2003，6，3： | 1 |
| 7 | A least-squares finite element scheme for the RLW equation显示文摘 | GARDNER L R T GARDNER G A DOGAN A | 1996 | Communications in Numerical Methods in Engineering1996，12，： | 1 |
| 8 | Comparison of local anaesthesia with dexmedetomidine sedation and general anaesthesia during septoplasty 显示文摘 | Dogan R Erbek S | 2010 | Eur J Anaesthesiol2010，27，7： | 1 |
| 9 | Investigation of a rotor bearing assembly incorporating a squeeze-film damper bearing显示文摘 | Holmes R Dogan M | 1982 | Journal of Mechanical Engineering Science1982，24，3： | 1 |
| 10 | Surgical management of renal cell carcinoma with inferior vena cava tumor thrombus显示文摘 | Ekici S Dogan R | 2002 | Am J Surg2002，183，3： | 1 |
| 11 | Effect of hormone replacement therapy on CD4+ and CD8+ numbers,CD4+/CD8+ ratio,and immunoglobulin levels in hemodialysis patients显示文摘 | Dogan E Erkoc R Demir C | 2005 | Ren Fail2005，27，4： | 1 |
| 12 | Nephropathy and reti- nopathy in type 2 diabetic patients living at moderately high alti- tude and sea level 显示文摘 | Sayarlioglu H Erkoc R Dogan E | 2005 | Ren Fail2005，27，1： | 1 |
| 13 | Devega's Tricuspidannuloplasty: analysis of 195 patients 显示文摘 | Pasaoglu I Demicrin M Dogan R | 1990 | Thorac Cardiaovascular Surgery1990，38，6： | 1 |
| 14 | Prediction of stereoscopic video quality using objective quality models of 2-D video 显示文摘 | Hewage C T E R Worrall S T Dogan S | 2008 | Electronics Letters2008，44，16： | 1 |
| 15 | Effectiveness of som atostatin in the conservative management of chylothorax显示文摘 | DOGAN R DEM IRCIN M DOGAN OF | 2004 | Turk J Pediatr2004，46，3： | 1 |
| 16 | The use of large volume low pressure nasal saline with fluticasone propionate for the treatment of pediatric acute rhinosinusitis显示文摘 | TUGRUL S DOGAN R EREN S B | 2014 | Int J Pediatr Otorhinolaryngol2014，78，： | 1 |
| 17 | Laboratory wear testing of terrous alloys and composites 显示文摘 | Hawk J A Wilson R D Dogan O N | 1998 | AFS Transactions1998，106，： | 1 |
| 18 | Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat brain 显示文摘 | Raghavendra R V L Dogan A Todd K G | 2001 | J Neurosci2001，21，6： | 1 |
| 19 | H5N1 avian influenza in children显示文摘 | Oner AF Dogan N Gasimov V Adisasmito W Coker R Chan PK | 2012 | Clin Infect Dis2012，55，1： | 1 |
| 20 | Liquid phase aldol condensation reactions with MgO-ZrO (2) and shape-selective nitrogen-substituted NaY 显示文摘 | SHEN W Q TOMPSETT G A HAMMOND K D XING R DOGAN F GREY C P CONNER W C AUERBACH S M HUBER G W | 2011 | Appl Catal A2011，392，12： | 1 |
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