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| 1 | Neglected tropical diseases:an effective global response to local poverty-related disease priorities显示文摘Background:Neglected tropical diseases(NTDs)have long been overlooked in the global health agenda.They are intimately related to poverty,cause important local burdens of disease,but individually do not represent global priorities.Yet,NTDs were estimated to affect close to 2 billion people at the turn of the millennium,with a collective burden equivalent to HIV/AIDS,tuberculosis,or malaria.A global response was therefore warranted.Main text:The World Health Organization(WHO)conceived an innovative strategy in the early 2000s to combat NTDs as a group of diseases,based on a combination of five public health interventions.Access to essential NTD medicines has hugely improved thanks to strong public-private partnership involving the pharmaceutical sector.The combination of a WHO NTD roadmap with clear targets to be achieved by 2020 and game-changing partner commitments endorsed in the London Declaration on Neglected Tropical Diseases,have led to unprecedented progress in the implementation of large-scale preventive treatment,case management and care of NTDs.The coming decade will see as challenges the mainstreaming of these NTD interventions into Universal Health Coverage and the coordination with other sectors to get to the roots of poverty and scale up transmissionbreaking interventions.Chinese expertise with the elimination of multiple NTDs,together with poverty reduction and intersectoral action piloted by municipalities and local governments,can serve as a model for the latter.The international community will also need to keep a specific focus on NTDs in order to further steer this global response,manage the scaling up and sustainment of NTD interventions globally,and develop novel products and implementation strategies for NTDs that are still lagging behind.Conclusions:The year 2020 will be crucial for the future of the global response to NTDs.Progress against the 2020 roadmap targets will be assessed,a new 2021–2030 NTD roadmap will be launched,and the London Declaration commitments will need to be renewed.It is hoped that during the coming decade the global response will be able to further build on today’s successes,align with the new global health and development frameworks,but also keep focused attention on NTDs and mobilize enough resources to see the effort effectively through to 2030. | Dirk Engels Xiao-Nong Zhou | 2020 | Infectious Diseases of Poverty2020，9，1： | 4 |
| 2 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 3 | The cross-cutting contribution of the end of neglected tropical diseases to the sustainable development goals显示文摘The Sustainable Development Goals(SDGs)call for an integrated response,the kind that has defined Neglected Tropical Diseases(NTDs)efforts in the past decade.NTD interventions have the greatest relevance for SDG3,the health goal,where the focus on equity,and its commitment to reaching people in need of health services,wherever they may live and whatever their circumstances,is fundamentally aligned with the target of Universal Health Coverage.NTD interventions,however,also affect and are affected by many of the other development areas covered under the 2030 Agenda.Strategies such as mass drug administration or the programmatic integration of NTD and WASH activities(SDG6)are driven by effective global partnerships(SDG17).Intervention against the NTDs can also have an impact on poverty(SDG1)and hunger(SDG2),can improve education(SDG4),work and economic growth(SDG8),thereby reducing inequalities(SDG10).The community-led distribution of donated medicines to more than 1 billion people reinforces women’s empowerment(SDG5),logistics infrastructure(SDG9)and non-discrimination against disability(SDG16).Interventions to curb mosquito-borne NTDs contribute to the goals of urban sustainability(SDG11)and resilience to climate change(SDG13),while the safe use of insecticides supports the goal of sustainable ecosystems(SDG15).Although indirectly,interventions to control waterand animal-related NTDs can facilitate the goals of small-scale fishing(SDG14)and sustainable hydroelectricity and biofuels(SDG7).NTDs proliferate in less developed areas in countries across the income spectrum,areas where large numbers of people have little or no access to adequate health care,clean water,sanitation,housing,education,transport and information.This scoping review assesses how in this context,ending the epidemic of the NTDs can impact and improve our prospects of attaining the SDGs. | Mathieu Bangert David H.Molyneux Steve W.Lindsay Christopher Fitzpatrick Dirk Engels | 2017 | Infectious Diseases of Poverty2017，6，1： | 3 |
| 4 | Laparoscopy in Combination with Fast Track Multimodal Management is the Best Perioperative Strategy in Patients Undergoing Colonic Surgery: A Randomized Clinical Trial (LAFA-study)显示文摘 | Malaika S. Vlug Jan Wind Markus W. Hollmann Dirk T. Ubbink Huib A. Cense Alexander F. Engel Michael F. Gerhards Bart A. van Wagensveld Edwin S. van der Zaag Anna A.W. van Geloven Mirjam A.G. Sprangers Miguel A. Cuesta Willem A. Bemelman | 2011 | Annals of Surgery2011，，6： | 3 |
| 5 | Preoperative Helical Tomotherapy and Megavoltage Computed Tomography for Rectal Cancer: Impact on the Irradiated Volume of Small Bowel显示文摘 | Benedikt Engels Mark De Ridder Koen Tournel Alexandra Sermeus Peter De Coninck Dirk Verellen Guy A. Storme | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，5： | 1 |
| 6 | Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa显示文摘 | Marieke J van der Werf Sake J de Vlas Simon Brooker Caspar W.N Looman Nico J.D Nagelkerke J.Dik F Habbema Dirk Engels | 2003 | Acta Tropica2003，，2： | 1 |
| 7 | Reconsidering the underestimated burden caused by neglected tropical diseases显示文摘 | Dirk Engels Lorenzo Savioli | 2006 | Trends in Parasitology2006，22，8： | 1 |
| 8 | Drugs for the control of parasitic diseases: current status and development in schistosomiasis显示文摘 | Alan Fenwick Lorenzo Savioli Dirk Engels N. Robert Bergquist Matthew H. Todd | 2003 | Trends in Parasitology2003，，11： | 1 |
| 9 | Laparoscopy in Combination with Fast Track Multimodal Management is the Best Perioperative Strategy in Patients Undergoing Colonic Surgery: A Randomized Clinical Trial (LAFA-study)显示文摘 | Malaika S. Vlug Jan Wind Markus W. Hollmann Dirk T. Ubbink Huib A. Cense Alexander F. Engel Michael F. Gerhards Bart A. van Wagensveld Edwin S. van der Zaag Anna A.W. van Geloven Mirjam A.G. Sprangers Miguel A. Cuesta Willem A. Bemelman | 2011 | Annals of Surgery2011，，6： | 1 |
| 10 | Soil-transmitted helminth infections: updating the global picture显示文摘 | Nilanthi R de Silva Simon Brooker Peter J Hotez Antonio Montresor Dirk Engels Lorenzo Savioli | 2003 | Trends in Parasitology2003，，12： | 1 |
| 11 | Soil-transmitted helminth infections: updating the global picture显示文摘 | Nilanthi R de Silva Simon Brooker Peter J Hotez Antonio Montresor Dirk Engels Lorenzo Savioli | 2003 | Trends in Parasitology2003，，12： | 1 |
| 12 | Phase II Study of Preoperative Helical Tomotherapy With a Simultaneous Integrated Boost for Rectal Cancer显示文摘 | Benedikt Engels Koen Tournel Hendrik Everaert Anne Hoorens Alexandra Sermeus Nicolas Christian Guy Storme Dirk Verellen Mark De Ridder | 2012 | International Journal of Radiation Oncology Biology Physics2012，，1： | 1 |
| 13 | The Performance of Venture-Backed Firms: The Effect of Venture Capital Company Characteristics 显示文摘 | Dirk Engel | 2004 | Industry & Innovation Volume 11 Issue 3 September 20042004，，： | 1 |
| 14 | Preoperative Helical Tomotherapy and Megavoltage Computed Tomography for Rectal Cancer: Impact on the Irradiated Volume of Small Bowel显示文摘 | Benedikt Engels Mark De Ridder Koen Tournel Alexandra Sermeus Peter De Coninck Dirk Verellen Guy A. Storme | 2009 | International Journal of Radiation Oncology Biology Physics2009，，5： | 1 |
| 15 | Phase II Study of Preoperative Helical Tomotherapy for Rectal Cancer显示文摘 | Mark De Ridder Koen Tournel Yves Van Nieuwenhove Benedikt Engels Anne Hoorens Hendrik Everaert Bart Op de Beeck Vincent Vinh-Hung Jacques De Grève Georges Delvaux Dirk Verellen Guy A. Storme | 2008 | International Journal of Radiation Oncology Biology Physics2008，，3： | 1 |
| 16 | Assessment of Intrafractional Movement and Internal Motion in Radiotherapy of Rectal Cancer Using Megavoltage Computed Tomography显示文摘 | Koen Tournel Mark De Ridder Benedikt Engels Paul Bijdekerke Yves Fierens Michael Duchateau Nadine Linthout Truus Reynders Dirk Verellen Guy Storme | 2008 | International Journal of Radiation Oncology Biology Physics2008，，3： | 1 |
| 17 | Current practice in nutritional support and its association with mortality in septic patients—Results from a national, prospective, multicenter study显示文摘 | Gunnar Elke Dirk Sch?dler Christoph Engel Holger Bogatsch Inez Frerichs Maximilian Ragaller Jens Scholz Frank M. Brunkhorst Markus L?ffler Konrad Reinhart Norbert Weiler | 2008 | Critical Care Medicine2008，，6： | 1 |
| 18 | Laparoscopy in Combination with Fast Track Multimodal Management is the Best Perioperative Strategy in Patients Undergoing Colonic Surgery: A Randomized Clinical Trial (LAFA-study)显示文摘 | Malaika S. Vlug Jan Wind Markus W. Hollmann Dirk T. Ubbink Huib A. Cense Alexander F. Engel Michael F. Gerhards Bart A. van Wagensveld Edwin S. van der Zaag Anna A.W. van Geloven Mirjam A.G. Sprangers Miguel A. Cuesta Willem A. Bemelman | 2011 | Annals of Surgery2011，，6： | 1 |
| 19 | Firm-level implications of early stage venture capital investment--An empirical investigatian显示文摘 | Engel Dirk Keilbach M | 2007 | Joumal of Empiri- calFinance2007，，14： | 1 |
| 20 | World NTD Day 2022 and a new Kigali Declaration to galvanise commitment to end neglected tropical diseases显示文摘The World Health Organization’s first roadmap and the London Declaration on neglected tropical diseases(NTDs)have allowed an unprecedented expansion of interventions to control and eliminate this group of infectious diseases that primarily affects vulnerable or marginalised communities.The 2021-2030 NTD roadmap sustains a further acceleration of interventions but also introduces a broader and more ambitious agenda,calling to be accompanied by a new political declaration.Sponsored by the Government of Rwanda,the Kigali Declaration on neglected tropical diseases will be launched in 2022 to renew and reinvigorate commitments to end NTDs,also in the wake of the current setback caused by the COVID-19 pandemic.Starting on World NTD Day 2022,a global campaign'100%Committed'will call on a broad range of stakeholders to sign the declaration and make bold financial and political commitments towards achieving the 2030 roadmap and Sustainable Development Goals'targets for NTDs. | Thoko Elphick-Pooley Dirk Engels on behalf of Uniting to Combat NTDs | 2022 | Infectious Diseases of Poverty2022，11，1： | 0 |
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