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| 1 | 21世纪的工程教育重构显示文摘工程教育与产业正面临着新挑战。有人认为这是工程教育的危机,也有人认为这是我们步入21世纪为工程教育带来的机遇。客观地讲,没有人对工程教育的现状以及短期内面临的问题十分满意。正如狄更斯在《双城记》开头中写到,“现在是最好的时候,也是最糟的时刻”。 | Gretar Tryggvason Diran Apelian 查建中 冯磊 | 2008 | 中国大学教学2008，，12： | 8 |
| 2 | Effect of mixing rate and temperature on primary Si phase of hypereutectic Al-20Si alloy during control ed diffusion solidification(CDS) process显示文摘Controlled Diffusion Solidification(CDS) is a promising process relied on mixing two liquid alloys of precisely controlled chemistry and temperature in order to produce a predetermined alloy composition. In this study, the CDS was employed to prepare hypereutectic Al-20%Si(mass fraction) alloy using Al-30%Si and pure Al of different temperatures. The mixing rate was controlled using three small crucibles with a hole of different diameters in their bottom. The effect of mixing rate and temperature on the microstructure of the primary Si-phase during the mixing of molten Al and Al-30%Si was studied. The results showed that when the diameter of the small crucible bottom hole is 16 mm, a higher mass mixing rate 0.217 kg·s-1 would results in a lower stream velocity 0.414 m·s-1. Conversely a lower mass mixing rate 0.114 kg·s-1(the diameter of the small crucible bottom hole is 8 mm) would result in a higher fluid stream velocity 0.879 m·s-1. A lower mass mixing rate would be better to refine the primary Si than a higher mass mixing rate. Meanwhile, the morphology and distribution of primary Si could also be improved. Especially, when Al-30%Si alloy at 820 °C was mixed with pure Al at 670 °C in the case of a mass mixing rate of 0.114 kg·s-1 and a pouring temperature of 680 °C, the average size of the primary Si phase would be only 18.2 μm. Its morphology would mostly be octahedral and the primary Si would distribute uniformly in the matrix microstructure. The lower mass mixing rate(0.114 kg·s-1) will enhance the broken tendency of Al-30%Si steam and the mixing agitation of resultant melt, so the primary Si phase can be better refined. | Yuan-dong Li Xin-long Zhang Ying Ma Diran Apelian Hong-wei Zhou Xing-hai Liu | 2015 | China Foundry2015，12，3： | 5 |
| 3 | Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation显示文摘AIM To investigate the relation of two different mutations to the outcome of partial external biliary diversion(PEBD)in severe bile salt export pump(BSEP) deficiency.METHODS Mutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney(HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization. Bile acid profiles of patient and control bile samples were generated by ultra-performance liquid chromatographytandem mass spectrometry. Wild-type and mutant BSEP transport of [~3H]-labeled taurocholate(TC) and taurochenodeoxycholate(TCDC) was assessed by vesicular transport assays.RESULTS A girl(at 2 mo) presented with pruritus, jaundice and elevated serum bile salts(BS). PEBD stabilized liver function and prevented liver transplantation. She was heterozygous for the BSEP deletion p.T919 del and the nonsense mutation p.R1235 X. At the age of 17 years relative amounts of conjugated BS in her bile were normal, while total BS were less than 3% as compared to controls. An unrelated boy(age 1.5 years) presenting with severe pruritus and elevated serum BS was heterozygous for the same nonsense and another missense mutation, p.G1032 R. PEBD failed to alleviate pruritus, eventually necessitating liver transplantation. BS concentration in bile was about 5% of controls. BS were mainly unconjugated with an unusual low amount of chenodeoxycholate derivatives(< 5%). The patients' native liver biopsies showed canalicular BSEP expression. Both BSEP p.T919 del and p.G1032 R were localized in the plasma membrane in HEK293 cells. In vitro transport assays showed drastic reduction of transport by both mutations. Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecules per wild-type BSEP transporter per minute, respectively.CONCLUSION In summary, our findings suggest that residual function of BSEP as well as substrate specificity influence the therapeutic effectiveness of PEBD in progressive familial intrahepatic cholestasis type 2(PFIC-2). | Philipp Ellinger Jan Stindt Carola Droge Katharina Sattler Claudia Stross Stefanie Kluge Diran Herebian Sander HJ Smits Martin Burdelski Sebastian Schulz-Jürgensen Antje Ballauff Jan Schulte am Esch Ertan Mayatepek Dieter Haussinger Ralf Kubitz Lutz Schmitt | 2017 | World Journal of Gastroenterology2017，23，29： | 4 |
| 4 | SPQD14120800011178显示文摘 | Kordes Claus Sawitza Iris G?tze Silke Herebian Diran H?ussinger Dieter | 2014 | Journal of Clinical Investigation2014，，12： | 2 |
| 5 | Relationships between mierostructure and fatigue crack propagation paths in A1 - Si - Mg cast alloys 显示文摘 | LADOS DIANA A APELIAN Diran | 2008 | Engineering Fracture Mechanics2008，75，： | 1 |
| 6 | Implantable Cardioverter-Defibrillator Therapy for Prevention of Sudden Death in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia显示文摘 | Domenico Corrado Loira Leoni Mark S. Link Paolo Della Bella Fiorenzo Gaita Antonio Curnis Jorge Uriarte Salerno Diran Igidbashian Antonio Raviele Marcello Disertori Gabriele Zanotto Roberto Verlato Giuseppe Vergara Pietro Delise Pietro Turrini Cristina Ba | 2003 | Circulation: Journal of the American Heart Association2003，，25： | 1 |
| 7 | Relationships between microstructure and fatigue crack propagation paths in A1-Si-Mg cast alloys显示文摘 | Diana A Diran Apelian | 2008 | Engineering Fracture Mechanics2008，75，： | 1 |
| 8 | Melting metal powder particles in an inductively coupled r.f. plasma torch显示文摘 | Daniel Y. C. Wei Bakhtier Farouk Diran Apelian | 1988 | Metallurgical Transactions B1988，，1： | 1 |
| 9 | Microstructural mechanisms controlling fatigue crack growth in AI-Si-Mg cast alloys 显示文摘 | Diana A Lados Diran A et ol | 2007 | Materials Science and Engineering2007，，： | 1 |
| 10 | Coagulation on biomaterials in flowing blood:sone theoretical considerations显示文摘 | Diran Basmadjian Michael V S Susan A B | 1997 | Biomaterials1997，18，23： | 1 |
| 11 | Abbreviated hospitalizationfor deep venous thmmbsis with the use of Ardeparin显示文摘 | Goldhaber SZ Morrison RB Diran EL | 1998 | Aeeh Inter Med1998，158，21： | 1 |
| 12 | The role of the lymphotoxin-βreceptor(LTβR)in hepatocyte-mediated liver regeneration显示文摘 | Kristina B Ursula R S Diran H | 2014 | European Journal of Medical Research2014，19，1： | 1 |
| 13 | Die soldering-mechanism ofthe interface reaction between molten aluminum alloy and toolsteel显示文摘 | Sumanth Shankar Diran Apelian | 2002 | Metallurgical and materials transactions B2002，33，： | 1 |
| 14 | 显示文摘 | Diana A Lados Diran Apelian | 2004 | Mater Sci Eng2004，385，： | 1 |
| 15 | 显示文摘 | Diana A Lados Diran Apelian | 2004 | Mater Sci Eng2004，385，： | 1 |
| 16 | Heat treating technology roadmap update 2004,part V ,institutional initiatives 显示文摘 | Diran Apellian Robert Gaster | 2004 | Heat Treating Progress2004，，910： | 1 |
| 17 | Heat Treating Technology Roadmap Update 2004, Part Ⅴ, Institutional Initiatives 显示文摘 | Diran Apellian Robert Gaster | 2004 | Heat Treating Progress2004，，910： | 1 |
| 18 | Heat treating industry R&D needs:a CHTE perspective 显示文摘 | Diran Apellian | 2003 | Heat Treating Progress2003，，12： | 1 |
| 19 | Heat Treating Industry R&D Needs:A CHTE Perspective 显示文摘 | Diran Apellian | 2003 | Heat Treating Progress2003，，12： | 1 |
| 20 | Die soldering: Mechanism of the interface reaction between molten aluminum alloy and tool steel显示文摘 | SUMANTH S DIRAN A | 2002 | Metallurgical and Materials Transactions B2002，33，3： | 1 |
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