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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 3 | The copigmentation effect of sinapie acid on malvin : a spectroscopic in- vestigation on colour enhancement 显示文摘 | DIMITRI M J M PETRANOVI N A BARANAC J M | 2005 | J Photoehem and Photobi- ology2005，78，： | 1 |
| 4 | Integration of deformable contours and a multiple hypotheses fisher color model for robust tracking in varying illuminant environments 显示文摘 | FRANCESC M N ALBERTO S DIMITRIS S | 2007 | Image and Vision Computing2007，25，： | 1 |
| 5 | Quantify- ing the spoilage and shelf-life of yoghurt with fruits显示文摘 | MATARAGAS M DIMITRIOU V SKANDAMIS P N | 2010 | Food Microbiol2010，28，3： | 1 |
| 6 | Indications for familial screening and gonadectomy in patients with 46, XY gonadal dysgenesis 显示文摘 | Dimitri P Cohen M Wright N | 2006 | Int J Gynaecol Obstet2006，95，2： | 1 |
| 7 | A socio-economic comparison of hemodialysis and peritoneal dialysis in Greece显示文摘 | Nick K Dimitris N John M | 2005 | Int J Heahhcare Technology and Management2005，6，3： | 1 |
| 8 | Market risk model selection and medium-term risk with limited data: application to ocean tanker freight mar- kets显示文摘 | KAVUSSANOS M G DIMITRIS N D | 2011 | Int Rev of Financial Anal2011，20，5： | 1 |
| 9 | Spectrophotometric study of anthocyan copigmentation reactions malvin and the nonglycosidized flavone quercetin 显示文摘 | Baranac J M Petranovi N A Dimitri | 1997 | Journal of Agricultural and Food Chemistry1997，45，5： | 1 |
| 10 | Robust design simu- lation:a probabilistic approach to multidisciplinary design 显示文摘 | Dimitri N M Oliver B Daniel A D | 1999 | Journal of Aircraft1999，36，1： | 1 |
| 11 | Thecopigmentation effect of sinapic acid on malvin: a spectroscopic investi-gation on colour enhancement显示文摘 | DIMITRI M J M PETRANOVI N A BARANAC J M | 2005 | Photochemistxy and Photobiology B2005，78，3： | 1 |
| 12 | H-order discontinuous Galerkin methods using an hp-multigrid approach显示文摘 | Cristian R N Dimitri J M | 2006 | Journal of Computational Physics2006，213，： | 1 |
| 13 | Storage response of cactus pear fruit following hot water brushing显示文摘 | DIMITRIS L POMPODAKIS N MARKELLOU E LIONAKIS S M | 2005 | Postharvest Biology and Technology2005，38，： | 1 |
| 14 | Words apart:Standardizing forestry terms and definitions across European biodiversity studies显示文摘Forest biodiversity studies conducted across Europe use a multitude of forestry terms,often inconsistently.This hinders the comparability across studies and makes the assessment of the impacts of forest management on biodiversity highly context-dependent.Recent attempts to standardize forestry and stand description terminology mostly used a top-down approach that did not account for the perspectives and approaches of forest biodiversity experts.This work aims to establish common standards for silvicultural and vegetation definitions,creating a shared conceptual framework for a consistent study on the effects of forest management on biodiversity.We have identified both strengths and weaknesses of the silvicultural and vegetation information provided in forest biodiversity studies.While quantitative data on forest biomass and dominant tree species are frequently included,information on silvicultural activities and vegetation composition is often lacking,shallow,or based on broad and heterogeneous classifications.We discuss the existing classifications and their use in European forest biodiversity studies through a novel bottom-up and top-driven review process,and ultimately propose a common framework.This will enhance the comparability of forest biodiversity studies in Europe,and puts the basis for effective implementation and monitoring of sustainable forest management policies.The standards here proposed are potentially adaptable and applicable to other geographical areas and could be extended to other forest interventions. | Giovanni Trentanovi Thomas Campagnaro Tommaso Sitzia Francesco Chianucci Giorgio Vacchiano Christian Ammer MichałCiach Thomas ANagel Miren del Río Yoan Paillet Silvana Munzi Kris Vandekerkhove Andrés Bravo-Oviedo Andrea Cutini Ettore D'Andrea Pallieter De Smedt Inken Doerfler Dimitris Fotakis Jacob Heilmann-Clausen Jeňýk Hofmeister Jan Hošek Philippe Janssen Sebastian Kepfer-Rojas Nathalie Korboulewsky Bence Kovács Daniel Kozák Thibault Lachat Anders Mårell Radim Matula Martin Mikoláš Björn Nordén PéterÓdor x Marko Perović Elisabeth Pötzelsberger Peter Schall Miroslav Svoboda Flóra Tinya Mariana Ujházyová Sabina Burrascano | 2023 | Forest Ecosystems2023，10，4： | 0 |
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