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| 1 | TME术前短程放疗后化疗对比术前放化疗联合术后辅助化疗治疗局部晚期直肠癌(RAPIDO研究)—一项随机、开放的Ⅲ期临床试验显示文摘背景:全身复发仍然是局部晚期直肠癌患者需要面临的难题。该研究是采用短程放疗后行化疗和延迟手术对比术前诱导治疗后直接手术疗效的临床试验(the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation,RAPIDO),旨在不影响局部控制效果的前提下减少远处转移。方法:在这项多中心、随机、开放的Ⅲ期试验中,参与者来自于荷兰、瑞典、西班牙、斯洛文尼亚、丹麦、挪威和美国的共54个医学中心。纳入患者年龄在18岁及以上,ECOG评分为0~1分,且为经活检确诊局部晚期原发直肠腺癌的初诊患者,盆腔MRI评估为高危(至少符合一项标准:cT4a或cT4b,壁外血管侵犯,cN2,直肠系膜筋膜受累,或侧方淋巴结增大)。患者具备化疗适应证,并可在随机分组前5周内完成分期评估。 | 李来元 张维胜 BAHADOER R R DIJKSTRA E A VAN ETTEN B | 2021 | 结直肠肛门外科2021，27，1： | 72 |
| 2 | Performance of the Montreal classification for inflammatory bowel diseases显示文摘AIM:To validate the Montreal classification system for Crohn's disease(CD) and ulcerative colitis(UC) within the Netherlands.METHODS:A selection of 20 de-identified medical records with an appropriate representation of the inflammatory bowel disease(IBD) sub phenotypes were scored by 30 observers with different professions(gastroenterologist specialist in IBD,gastroenterologist in training and IBD-nurses) and experience level with IBD patient care.Patients were classified according to the Montreal classification.In addition,participants were asked to score extra-intestinal manifestations(EIM) and disease severity in CD based on their clinical judgment.The inter-observer agreement was calculated by percentages of correct answers(answers identical to the 'expert evaluation') and Fleiss-kappa(k).Kappa cutoffs:< 0.4-poor; 0.41-0.6-moderate; 0.61-0.8-good; > 0.8 excellent.RESULTS:The inter-observer agreement was excellent for diagnosis(k = 0.96),perianal disease(k = 0.92) and disease location in CD(k = 0.82) and good for age of onset(k = 0.67),upper gastrointestinal disease(k = 0.62),disease behaviour in CD(k = 0.79) and disease extent in UC(k = 0.65).Disease severity in UC was scored poor(k = 0.23).The additional items resulted in a good inter-observer agreement for EIM(k = 0.68) and a moderate agreement for disease severity in CD(k = 0.44).Percentages of correct answers over all Montreal items give a good reflection of the inter-observer agreement(> 80%),except for disease severity(48%-74%).IBD-nurses were significantly worse in scoring upper gastrointestinal disease in CD compared to gastroenterologists(P = 0.008) and gastroenterologists in training(P = 0.040).Observers with less than 10 years of experience were significantly better at scoring UC severity than observers with 10-20 years(P = 0.003) and more than 20 years(P = 0.003) of experience with IBD patient care.Observers with 10-20 years of experience with IBD patient care were significantly better at scoring upper gastrointestinal disease in CD than observers with less than 10 years(P = 0.007) and more than 20 years(P = 0.007) of experience with IBD patient care.CONCLUSION:We found a good to excellent interobserver agreement for all Montreal items except for disease severity in UC(poor). | Lieke M Spekhorst Marijn C Visschedijk Rudi Alberts Eleonora A Festen Egbert-Jan van der Wouden Gerard Dijkstra Rinse K Weersma | 2014 | World Journal of Gastroenterology2014，20，41： | 4 |
| 3 | 青贮饲料中接种乳酸菌对黑白花奶牛甲烷排放和生产性能的影响显示文摘乳酸菌菌剂(LAB)通过增加青贮饲料中乳酸和其他有机酸类含量、降低饲料p H来提高饲料品质,防止酸败。本试验在青贮饲料中添加LAB,改变青贮饲料品质及其在瘤胃中的发酵条件,探索饲料中添加LAB对奶牛干物质采食量(DMI)、消化率、产奶量、牛奶品质和甲烷(CH4)排放量的影响。8头泌乳中期荷斯坦-黑白花杂交奶牛根据产奶量分成高产和低产两组,采用4×4拉丁方阵设计21 d试验。CH_4排放量采用间接量热法测量。各组青贮饲料(主要成分为黑麦草)分为空白组、长期添加LAB组、短期添加组(饲喂前16 h添加)和长短期综合添加组。所有饲料都由牧草青贮和复合物构成(干物质基础上的比例为7525)。长期添加组菌剂中植物乳杆菌、乳酸乳球菌和布氏乳杆菌比例为102070,短期添加组为乳酸乳球菌。试验结果表明,长期添加组和短期添加组对奶牛干物质摄入量(DMI)、中性洗涤纤维(NDF)、脂肪消化率、氮含量和能量平衡无显著影响,对乳成分(尤其是尿素)、乳脂肪、乳蛋白质和牛奶中微生物总数均无显著影响。但长期添加LAB使产奶量有增加趋势。长期添加组和短期添加组的奶牛中CH_4排放量无显著变化。其中,长期添加组中以k J·kg^(-1)为单位的代谢体重有提高趋势。试验结果得出引起动物生产性能改变的LAB最小添加量,包括长期和短期的。虽然其他研究表明青贮饲料中添加菌剂能对奶牛生产性能产生有利的显著影响,但本试验由于剂量、青贮饲料基底牧草选择和保存条件等因素的差异,未产生显著影响。 | Ellis J L Hindrichsen I K Klop G Kinley R D Milora N Bannink A Dijkstra J | 2016 | 饲料博览2016，0，9： | 3 |
| 4 | 13C andl5N natural abundance of the soil microbial biomass显示文摘 | Dijkstra P Ishizu A Doucett R Hart S C Schwartz E Menyailo O V Hungate B A | 2006 | Soil Biology & Biochemistry2006，38，： | 1 |
| 5 | Particle packing in loess deposits and the problem of structure collapse and hydroconsolidation 显示文摘 | DIJKSTRA T A SMALLEY I J ROGERS E D F | 1995 | Engi- neering Geology1995，40，： | 1 |
| 6 | Re- cent advances in modeling nutrient utilization in rumi-nants 显示文摘 | KEBREAB E DIJKSTRA J BANNINK A | 2009 | Journal of Animal Science2009，87，14： | 1 |
| 7 | Metastable liquid - liquid and solid - liquid phase boundaries in polymer - solvent -nonsolvent systems 显示文摘 | VandeWitte P Dijkstra P J VandenBerg J W A | 1997 | Journal of Polymer Science Part B: Polymer Physics1997，35，5： | 1 |
| 8 | Crystal structure of Escherichia coli lyric transglycosylase Slt35 reveals a lysozyme-like catalytic domain with an EF-hand 显示文摘 | Van Asselt E J Dijkstra A J Kalk K H | 1999 | Structure1999，7，10： | 1 |
| 9 | Instability of the thermohaline ocean circulation on interdecadal timescales显示文摘 | Te RAA L A DIJKSTRA H A | 2002 | Journal of Physical Oceanography2002，32，1： | 1 |
| 10 | Assessment of oral mueositis in clinical trials:impact of lraining on evaluators in a multi-centre trial 显示文摘 | Stokman M A Sonis S T Dijkstra P U | 2005 | Eur J Cancer2005，41，12： | 1 |
| 11 | Health and nursing problems of elderly patients related to bio-psycho-social need deficiencies and functionalassessment显示文摘 | Muszalik M Dijkstra A Kedziora-Kornatowska K | 2012 | Arch Gerontol Geriatr2012，55，1： | 1 |
| 12 | Quantifying the effect of monensin? dose on the rumen volatile fatty acid profile in high-grain-fed beef cattle显示文摘 | Ellis J L Dijkstra J Bannink A | 2012 | J Anim Sci2012，90，8： | 1 |
| 13 | The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3 显示文摘 | Dijkstra C D Dtipp E A Joling P | 1985 | Immunology1985，54，： | 1 |
| 14 | Interactions between soil and tree roots accelerate long-term soil carbon deeomposition显示文摘 | DIJKSTRA F A CHENG W | 2007 | Ecology Letters2007，10，： | 1 |
| 15 | Expression of ADAMs ('a disintegrin and metalloprotease') in the human lung 显示文摘 | Dijkstra A Postma DS Noordhoek JA | 2009 | VirchowsAreh2009，454，4： | 1 |
| 16 | Optimal localized observations for advancing beyond the ENSO predictability barrier显示文摘 | KRAMER W DIJKSTRA H A | 2013 | Nonlinear Processes in Geophysics2013，20，2： | 1 |
| 17 | The heterogeneity of mononuclear phagocytes in lymphoid organs:distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1,ED2 and ED3显示文摘 | DIJKSTRA C D D?PP E A JOLING P | 1985 | Immunology1985，54，3： | 1 |
| 18 | Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease显示文摘 | Dijkstra G Moshagep H van Dullemen HM deJager-Krikken A Tiebosch AT Kleibeuker JH | 1998 | J Pathol1998，186，4： | 1 |
| 19 | Effects of short-and long-chain fatty acids on the expression of stearoyl-CoA desaturase and other lipogenic genes in bovine mammary epithelial cells显示文摘 | Jacobs A A Dijkstra J Liesman J S | 2013 | Animal2013，7，9： | 1 |
| 20 | Dry-rewetting cycles regulate wheat carbon rhizodeposition,stabilization and nitrogen cycling显示文摘 | Canarini A Dijkstra F A | 2015 | Soil Biology&Biochemistry2015，81，： | 1 |
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