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48篇 您的检索式:作者名="Dicker J"
    题名 作者 年代 出处 被引量
1RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone.Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M 2013中国神经肿瘤杂志2013,11,1:8
2Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction显示文摘Peng J Dicker B Du W 2007J Autoimmun2007,28,4:1
3Relationship between varicocecle size and response to varicocelectomy 显示文摘STECKEL J DICKER A P GOLDSTEIN M 1993J Urol1993,149,4:1
4Minidose gonadotropin releasing hormone agonist is the treatment of choice in poor responders with high follicle stimulation hormone levels显示文摘Felberg D Dicker D Farhi J 1994Fertil Steril1994,64,2:1
5Solar glass with industrial porous SiO2 antireflection coating: measurements of photovoltaic module properties improvement and modelling of yearly energy yield gain显示文摘Ballif C Dicker J Borchert D 2004Solar Energy Materials & Solar Cells2004,82,:1
6Sorafenib sensitizes solid tumors to Apo2L/TRAIL and Apo2L/TRAIL receptor agonist antibodies by the Jak2-Stat3-Mcll axis显示文摘Abdulghani J Allen JE Dicker DT 2013PLoS One2013,8,75:1
7Can early implementation of salvage radiotherapy for prostate cancer improve the therapeutic ratio?A systematic review and regression meta-analysis with radiobiological modelling显示文摘Ohri N Dicker A P Trabulsi E J 2012Eur J Cancer2012,48,6:1
8Minidose ponsdotropin releasing bormone agonist is the treatment of choice in poor responders with high follicle-stimulating hormone levels显示文摘Felberg D Dicker D Parbi J 1994Fertil Steril1994,64,:1
9Severe abdominal compli-cations after transvaginal ultrasonographically guided retrieval ofoocytes for in vitro fertilization and embryo transfer显示文摘Dicker D Ashkenazi J Feldberg D 1993Fertil Ster-111993,59,6:1
10Effects of salinity on acetylene reduction(nitrogen fixation)and espiration in a marine Azotobacter显示文摘Dicker H J Smith D W 1981Appl Environ Microbiol1981,42,4:1
11Sorafenib sensitizes solid tumors to Apo2L/TRAIL and Apo2L/TRAIL receptor agonist antibodies by the Jak2-Stat3-Mcl] axis 显示文摘Abdulghani J Allen JE Dicker DT 2013PLoS One2013,8,75:1
12Transvaginal Ultrasonic Needle-Guided Aspiration of Endometriotic Cysts Before Ovulation Induction for in Vitro Fertilization显示文摘Dicker D Goldman J A Feldberg D 1991J in Vitro Fert Embryo Transf1991,8,5:1
13Solar glass with industrial porous SiO2 antireflection coating:measure-ments of photovoltaic module properties improvement and modeling of yearly energy yield gain显示文摘Ballif C Dicker J Borchert D 0,,03:1
14Severe abdominal complications after transvaginal ultrasonographically guided retrieval of oocytes for in vitro fertilization and embryo transfer显示文摘Dicker D Ashkenazi J Feldberg D 1993FertilSteril1993,59,6:1
15Predictinghydrate plug formation in oil-dominated flow lines 显示文摘Davies S R Boxall J A Dicker L E et 01 2010J Pet Sci Eng2010,72,:1
16Differentiation of normal skin and melanoma using high resolution hyperspectral imaging 显示文摘Dicker DT Lerner J Belle PV 2006Cancer Biology & Therapy2006,5,:1
17The effect of longterm adaptation to different levels of salinity on urea synthesis and tissueamino acid concentrations in Rana cancrivora 显示文摘Balinsky J B Dicker S E Elliott A B 1972Comp Biochem Physiol1972,43,:1
18Acute pelvic in- flammatory disease after oocyte retrieval: adverse effects on the results of implantation显示文摘Ashkenazi J Farhi J Dicker D 1994Fertil Steril1994,61,3:1
19Common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions 2 and 3 显示文摘Focking M Dicker P English J A 2011Arch Gen Psychiatry2011,68,5:1
20Effects of salinity on acetylene reduction (nitrogen fixation) and respiration in a marine Azotobacter显示文摘Dicker H J Smith D W 1981Appl Environ Microbiol1981,42,4:1
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