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| 1 | Textbook outcomes in hepatobiliary and pancreatic surgery显示文摘The concept of textbook outcome (TO) has recently gained popularity in surgicalresearch and has been used to evaluate the quality or success of different surgicalprocedures, including hepatopancreatobiliary (HPB) operations. TO consists ofindividual outcome parameters that each reflect different domains of careincluding structure, process, and individual outcomes;in turn, the composite TOmetric represents the optimal course after a surgical episode. TO can be used toassess patient-level outcomes, hospital performance, center designation andquality metrics. In addition to being an outcome measurement, TO may also belinked to healthcare costs. Future efforts should be directed towards establishing auniversal definition of TO in HPB surgery so that surgeons and hospitals canassess and compare outcomes, identify shortcomings and improve real worldpatient outcomes. | Diamantis I Tsilimigras Timothy Michael Pawlik Dimitrios Moris | 2021 | World Journal of Gastroenterology2021，27，15： | 6 |
| 2 | Cytokines as biomarkers of inflammatory response after open versus endovascular repair of abdominal aortic aneurysms: a systematic review显示文摘一个腹的大动脉的动脉瘤(AAA ) 的修理是与有煽动性的串联的随后的激活的神经质、新陈代谢的压力相关的反应有关的一个高风险的外科的过程。与开的修理相对照(或) , endovascular 大动脉的动脉瘤修理(EVAR ) 由为更少提供广泛的切口,解剖,和织物操作似乎是手术后的压力到减少。然而,这些有益的效果可以是由代谢物在用在 endovascular 的导管的血栓的 intra 钠操作期间修理的 cytokines 和 arachidonic 酸的版本的偏移量,导致全身的煽动性的反应(先生) ,它是临床上叫的培植以后的症候群。在我们比较了的这系统的评论或与 EVAR,以 post-interventional,从改变导致传播 cytokine 的煽动性的反应铺平。我们寻求了在 EVAR 以后关于培植以后的症候群总结所有最近的证据。我们寻找了为临床的研究作为煽动性的反应的部分在 cytokines 的版本上报导在以后的 Medline (PubMed ) , ClinicalTrials.gov 和 Cochrane 图书馆开 / 常规并且 AAA 的 endovascular 修理。我们鉴别 17 学习检验 cytokine 层次在以后或对 EVAR。或似乎特别地比 EVAR 与一位更大的先生被联系,由增加的 cytokine 层次证实了 IL-6 和 IL-8 而 IL-1, IL-10 和 TNF- 出现了,冲突在二之间的结果或没有差别组织。聚酯 endografts 看起来断然在 EVAR 以后与培植以后的症候群的发生被相关。未来大未来的研究被保证位于在 surgical 以后的 cytokine 相互作用下面描出的机制煽动性的反应背景。 | Diamantis I TSILIMIGRAS Fragiska SIGALA Georgios KARAOLANIS Ioannis NTANASIS-STATHOPOULOS Eleftherios SPARTALIS Michael SPARTALIS Nikolaos PATELIS Alexandros PAPALAMPROS Chandler LONG Demetrios MORIS | 2018 | Acta Pharmacologica Sinica2018，39，7： | 5 |
| 3 | Concept of histone deacetylases in cancer:Reflections on esophageal carcinogenesis and treatment显示文摘Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature. Squamous cell carcinoma is the most common histological type world-wide, though, a continuous increase in esophageal adenocarcinomas has been noted in the past decades. Common risk factors associated with EC include smoking, alcohol consumption, gastroesophageal reflux disease, Barrett's esophagus and obesity. In an effort to overcome chemotherapy resistance in oncology, it was discovered that histone acetylation/deacetylation equilibrium is altered in carcinogenesis, leading to changes in chromatin structure and altering expression of genes important in the cell cycle, differentiation and apoptosis. Based on this knowledge, histone acetylation was addressed as a potential novel chemotherapy drug target to repress cancer cell proliferation. There are four classes of histone deacetylases (HDACs) inhibitors with a variety of different mechanisms of actions that render them possible anticancer drugs. They arrest the cell cycle, inhibit differentiation and angiogenesis and induce apoptosis. They do not necessarily act on histone proteins, since they can also exert indirect anti-cancer effects, by modifying various cellular proteins.In addition,HDACs have also been associated with increased chemotherapy resistance.Based on the literature,HDACs have been associated with EC,with surveys revealing that increased expression of certain HDACs correlates with advanced TNM stages,tumor grade,metastatic potential and decreased 5-year overall and disease-free survival.The aim of this survey is to elucidate the molecular identity and mechanism of action of HDAC inhibitors as well as verify their potential utility as anti-cancer agents in esophageal cancer. | Dimitrios Schizas Aikaterini Mastoraki Leon Naar Eleftherios Spartalis Diamantis I Tsilimigras Georgia-Sofia Karachaliou George Bagias Dimitrios Moris | 2018 | World Journal of Gastroenterology2018，24，41： | 3 |
| 4 | Associations between serum relaxin 2, aneurysm formation/size and severity of atherosclerosis: a preliminary prospective analysis显示文摘(RL2 ) 浆液松弛激素 2 是对各种各样的机关和系统起作用的多种的荷尔蒙,特别地心血管的系统。尽管 RL2 似乎是氮的一氧化物的合成到 upregulate (没有) 并且它在动脉粥样硬化和动脉瘤形成的角色上的矩阵 metalloproteinase (MMP )-2 和 -9, 水流文学是少见的。这研究的目的是与一个动脉的动脉瘤以及在动脉粥样硬化患者病人在病人调查浆液 RL2 的层次,并且相关他们与他们的相关脉管的疾病的严厉。53 个题目的一个总数在这研究被注册:37 个病人被安排经历外科:为动脉粥样硬化患者疾病(ATH ) 的不同形式的 21 个病人,为一个动脉的动脉瘤(AA ) 的 16 个病人,为经历时间的动脉活体检视(标签) 的 6 个病人,和 10 个健康献血者(HBD ) 担任了控制组。RL2 用 enzymelinked immunosorbent 试金被测量。RL2 在与 ATH 相比的 AA 病人是显著地更高的(P < 0.01 ) ,标签(P < 0.001 ) 并且 HBD (P < 0.01 ) 。没有重要差别在 ATH 和标签组之间被发现(P > 0.05 ) 。另外, ATH 和 AA 病人进一步基于他们的疾病的严厉被细分。浆液 RL2 日益增多地与动脉的动脉瘤在病人被增加,显示出与 aneurysmatic 膨胀的尺寸的一种积极关系。由对比, RL2 水平是相反地与动脉粥样硬化患者疾病的严厉有关。有合并一张一致学习人口的一个更大的队的研究被保证验证我们的结果并且使这些过程的机械学的背景清楚些。 | Konstantinos PAPOUTSIS Alkistis KAPELOUZOU Diamantis I TSILIMIGRAS Nikolaos PATELIS Georgios KOUVELOS Dimitrios SCHIZAS Ioannis KARAVOKYROS Sotirios GEORGOPOULOS | 2018 | Acta Pharmacologica Sinica2018，39，7： | 2 |
| 5 | Novel approaches for the treatment of ventricular tachycardia显示文摘Ventricular tachycardia(VT) is a crucial cause of sudden cardiac death(SCD) and a primary cause of mortality and morbidity in patients with structural cardiac disease. VT includes clinical disorders varying from benign to lifethreatening. Most life-threatening episodes are correlated with coronary artery disease, but the risk of SCD varies in certain populations, with various underlying heart conditions, specific family history, and genetic variants. The targets of VT management are symptom alleviation, improved quality of life, reduced implantable cardioverter defibrillator shocks, prevention of reduction of left ventricular function, reduced risk of SCD, and improved overall survival. Antiarrhythmic drug therapy and endocardial catheter ablation remains the cornerstone of guideline-endorsed VT treatment strategies in patients with structural cardiac abnormalities. Novel strategies such as epicardial ablation, surgical cryoablation, transcoronary alcohol ablation, pre-procedural imaging, and stereotactic ablative radiotherapy are an appealing area of res-earch. In this review, we gathered all recent advances in innovative therapies as well as experimental evidence focusing on different aspects of VT treatment that could be significant for future favorable clinical applications. | Michael Spartalis Eleftherios Spartalis Eleni Tzatzaki Diamantis I Tsilimigras Demetrios Moris Christos Kontogiannis Efthimios Livanis Dimitrios C Iliopoulos Vassilis Voudris George N Theodorakis | 2018 | World Journal of Cardiology2018，10，7： | 2 |
| 6 | Differential expression of matrix metalloproteinase in viral and non-viral chronic liver diseases 显示文摘 | Ljumovie D Diamantis I Alegakis AK | 2004 | Chin Chim Acta2004，349，： | 1 |
| 7 | Vibration-noise optimization of a FEM railway wheel model显示文摘 | EFTHIMEROS G A PHOTEINOS D I DIAMANTIS Z G | 2002 | Eng Computations2002，19，8： | 1 |
| 8 | Synchronous resection of esophageal cancer and other organ malignancies: A systematic review显示文摘BACKGROUND Neoplasms arising in the esophagus may coexist with other solid organ or gastrointestinal tract neoplasms in 6%to 15%of patients.Resection of both tumors synchronously or in a staged procedure provides the best chances for long-term survival.Synchronous resection of both esophageal and second primary malignancy may be feasible in a subset of patients;however,literature on this topic remains rather scarce.AIM To analyze the operative techniques employed in esophageal resections combined with gastric,pancreatic,lung,colorectal,kidney and liver resections and define postoperative outcomes in each case.METHODS We conducted a systematic review according to PRISMA guidelines.We searched the Medline database for cases of patients with esophageal tumors coexisting with a second primary tumor located in another organ that underwent synchronous resection of both neoplasms.All English language articles deemed eligible for inclusion were accessed in full text.Exclusion criteria included:(1)Hematological malignancies;(2)Head/neck/pharyngeal neoplasms;(3)Second primary neoplasms in the esophagus or the gastroesophageal junction;(4)Second primary neoplasms not surgically excised;and(5)Preclinical studies.Data regarding the operative strategy employed,perioperative outcomes and longterm outcomes were extracted and analyzed using descriptive statistics.RESULTS The systematic literature search yielded 23 eligible studies incorporating a total of 117 patients.Of these patients,71%had a second primary neoplasm in the stomach.Those who underwent total gastrectomy had a reconstruction using either a colonic(n=23)or a jejunal(n=3)conduit while for those who underwent gastric preserving resections(i.e.,non-anatomic/wedge/distal gastrectomies)a conventional gastric pull-up was employed.Likewise,in cases of patients who underwent esophagectomy combined with pancreaticoduodenectomy(15%of the cohort),the decision to preserve part of the stomach or not dictated the reconstruction method(whether by a gastric pullup or a colonic/jejunal limb).For the remaining patients with coexisting lung/colorectal/kidney/liver neoplasms(14%of the entire patient population)the types of resections and operative techniques employed were identical to those used when treating each malignancy separately.CONCLUSION Despite the poor quality of available evidence and the great interstudy heterogeneity,combined procedures may be feasible with acceptable safety and satisfactory oncologic outcomes on individual basis. | Dimitrios Papaconstantinou Diamantis I Tsilimigras Dimitrios Moris Adamantios Michalinos Aikaterini Mastoraki Efstratia Mpaili Natasha Hasemaki Anargyros Bakopoulos Dimitrios Filippou Dimitrios Schizas | 2019 | World Journal of Gastroenterology2019，25，26： | 1 |
| 9 | Autoimmune hepatitis: Evolving concepts显示文摘 | Diamantis I Boumpas DT | 2004 | Autoimmun Rev2004，3，3： | 1 |
| 10 | Vibration/noise optimization of a FEM railway wheel model显示文摘 | EFTHIMEROS G A PHOTEINOS D I DIAMANTIS Z G | 2002 | Engineering Computations2002，19，8： | 1 |
| 11 | p53 protein expression in central nervous system tumors显示文摘 | Karamitopoulou E Parentes E Diamantis I | 1993 | Acta Neuropathol1993，85，6： | 1 |
| 12 | Autoimmune hepatitis: evolving concepts 显示文摘 | Diamantis I Boumpas DT | 2004 | Autoimmun Rev2004，3，3： | 1 |
| 13 | Increased serum advanced glycation end - products is a distinct finding in lean women with polycystic ovary syndrome (PCOS) 显示文摘 | Diamanti KE Katsikis I Piperi C | 2008 | Clin Endocrinol (Oxf)2008，69，4： | 1 |
| 14 | Vibration/noise optimization of a FEM railway wheel model 显示文摘 | Efthimeros G A Photeinos D I Diamantis Z G | 2002 | Engineering Computations2002，，2： | 1 |
| 15 | Comparison of single-and two-stage UASB reactors used for anaerobic treatment of synthetic fruit wastewater 显示文摘 | Vasileios I Diamantis Alexandros Aivasidis | 2007 | Enzyme and Microbial Technology2007，，42： | 1 |
| 16 | High aeration rateenhances flow stratification in full-scale oxidation ditch 显示文摘 | Diamantis V Papaspyrou I Melidis P | 2010 | Bioprocess and Biosystems Engineering2010，33，2： | 1 |
| 17 | In vitro evaluation of fluoride and calcium sodium phospho- silicate toothpastes, on root dentine caries lesions显示文摘 | Diamanti I Koletsi-Kounari H Mamai-Homata E | 2011 | J Dent2011，39，9： | 1 |
| 18 | Cloning of the rat ADAMTS-1 gene and its down regulation in endothelial cells in cirrhotic rats显示文摘 | Diamantis I Luthi M Hosli M | 2000 | Liver2000，20，2： | 1 |
| 19 | Effect of by_ pocaloric diet plus sibutramine treatment on hormonal and metabol- ic features in overweight and obese women with polycystic ovary syndrome : a randomized,24 - week study 显示文摘 | Florakis D Diamanti - Kandarakis E Katsikis I | 2008 | Int J Obes ( Lond)2008，32，4： | 1 |
| 20 | In vitro evaluation of fluoride and calcium sodium phosphosilicate toothpastes,on root dentine caries lesions显示文摘 | Diamanti I Koletsi-Kounari H Mamai-Homata E | 2011 | J Dent2011，39，9： | 1 |
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