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| 1 | Oxygen-deficient metal oxides:Synthesis routes and applications in energy and environment显示文摘Oxyge n vaca ncies impla ntation is an efficie nt way to adjust the physical and chemical properties of metal oxide nano materials to meet the requirements for particular applications.Through reasonable defects design,oxyge-deficient metal oxides with excellent optical and electrical properties are widely applied for environmental protection and energy uses.This review discusses recent advances in synthetic approaches of oxygervdeficient metal oxides and their applications in photocatalysis,electrocatalysis,and energy storage devices.The perspectives of oxyge n?deficie nt metal oxides for increased en ergy dema nd and en vironme ntal sustai liability are also exami ned. | Di Zu Haiyang Wang Sen Lin Gang Ou Hehe Wei Shuqing Sun Hui Wu | 2019 | Nano Research2019，12，9： | 9 |
| 2 | Room-temperature production of silver-nanofiber film for large-area, transparent and flexible surface electromagnetic interference shielding显示文摘A kind of pollution known as electromagnetic interference(EMI),which results from ubiquitous usage of various electronic communication and military radar equipment,has been receiving increasing attention recently.However,large-area EMI shielding on transparent and/or curved surfaces,including building windows,curved glass wall,and special requirements spaces(SRSs),remains hard to achieve.In this paper,a silver nanofiber(AgNF)based flexible and transparent EMI shielding film was successfully assembled via a room-temperature roll-to-roll production method.For transparent application scenario,AgNF with 89%transmittance in visible range and 1μm thickness shows~20 dB shielding efficiency(EMI SE).On the other hand,total shielding(>50 dB)is obtained when the thickness of AgNF increases to 10μm,while its transmittance in visible range remains higher than 75%.Considering the facile and scale-free production technology,this material can be readily applied in large-scale,transparent,and/or SRSs EMI shielding. | Sen Lin Haiyang Wang Fan Wu Qingmin Wang Xiaopeng Bai Di Zu Jianan Song Dong Wang Zhenglian Liu Ziwei Li Nian Tao Kai Huang Ming Lei Bo Li Hui Wu | 2019 | npj Flexible Electronics2019，3，1： | 4 |
| 3 | PITX2 in pancreatic stellate cells promotes EMT in pancreatic cancer cells via the Wnt/β-catenin pathway显示文摘Since the prognosis of patients with pancreatic cancer is very poor and there is a lack of treatment methods,this study is performed to investigate the function of PITX2 in pancreatic stellate cells(PSCs)in the progression of pancreatic cancer.Scientific hypotheses are proposed according to bioinformatics analysis and tissue microarray analysis.Stable knockdown of PITX2 in PSCs is achieved through lentiviral infection.The relative expressions of PITX2,α-SMA,vimentin,CTNNB1,AXIN1 and LEF1 are measured in wild-type PSCs and PITX2-knockdown PSCs.Proliferative capacity is measured by EdU assay.After coculture with PSCs,the proliferation,invasion and migration capacity of pancreatic cancer cells are tested.EMT and Wnt/β-catenin downstream genes of pancreatic cancer cells are investigated to reveal the potential mechanism.Bioinformatics analysis reveals that the PITX2 gene is highly expressed in stromal cells in pancreatic cancer and is correlated with squamous-type PDAC.Analysis of PDAC tissue microarray further demonstrates that high PITX2 level in stromal cells is correlated with poor prognosis in PDAC.After stable knockdown of PITX2 in PSCs,the relative protein levels ofα-SMA,vimentin,CTNNB1,AXIN1 and LEF1 are decreased,and the proliferative capacity of PSCs is also decreased.After coculture with PSCs,in which PITX2 expression is downregulated,the proliferation,invasion and migration capacities of pancreatic cancer cells are inhibited.Thus,our results show that PITX2-silenced PSCs inhibit the growth,migration and invasion of pancreatic cancer cells via reduced EMT and Wnt/β-catenin signaling. | Di Wu Weibo Chen Yang Yang Yi Qin Guangchen Zu Yue Zhang Yong An Donglin Sun Xiaowu Xu Xuemin Chen | 2023 | Acta Biochimica et Biophysica Sinica2023，55，9： | 1 |
| 4 | A positive feedback loop of ARF6 activates ERK1/2 signaling pathway via DUSP6 silencing to promote pancreatic cancer progression显示文摘ERK1/2 are essential proteins mediating mitogen-activated protein kinase signaling downstream of RAS in pancreatic adenocarcinoma(PDAC).Our previous study reveals that ARF6 plays a positive regulatory role in ERK1/2 pathway in a feedback loop manner.A significant part of the literature on ARF6 has emphasized its oncogenic effect as an essential downstream molecule of ERK1/2,and no research has been done on the regulation mechanisms of the feedback loop between ARF6 and the ERK1/2 signaling pathway.In the present study,we explore the gene network downstream of ARF6 and find that DUSP6 may be the critical signal molecule in the positive feedback loop between ARF6 and ERK1/2.Specifically,to elucidate the negative correlations between ARF6 and DUSP6 in pancreatic cancer,we examine their expressions in pancreatic cancer tissues by immunohistochemical staining.Then the impact of DUSP6 on the proliferation and apoptosis of PDAC cells are investigated by gain-of-function and loss-of-function approaches.Mechanism explorations uncover that ARF6 suppresses the expression of DUSP6,which is responsible for the dephosphorylation of ERK1/2.Altogether,these results indicate that DUSP6 plays a tumor-suppressive role and acts as an intermediate molecule between ARF6 and ERK1/2 in PDAC cells,thereby forming a positive feedback loop. | Bingkai Xiao Yue Zhang Zekun Lu Weibo Chen Yong An Guangchen Zu Xiaowu Xu Di Wu Hao Yang Yi Qin Xuemin Chen | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 0 |
| 5 | Active-Sensing Epidermal Stretchable Bioelectronic Patch for Noninvasive,Conformal,and Wireless Tendon Monitoring显示文摘Sensors capable of monitoring dynamic mechanics of tendons throughout a body in real time could bring systematic information about a human body’s physical condition,which is beneficial for avoiding muscle injury,checking hereditary muscle atrophy,and so on.However,the development of such sensors has been hindered by the requirement of superior portability,high resolution,and superb conformability.Here,we present a wearable and stretchable bioelectronic patch for detecting tendon activities.It is made up of a piezoelectric material,systematically optimized from architectures and mechanics,and exhibits a high resolution of 5:8×10^(−5)N with a linearity parameter of R^(2)=0:999.Additionally,a tendon real-time monitoring and healthcare system is established by integrating the patch with a micro controller unit(MCU),which is able to process collected data and deliver feedback for exercise evaluation.Specifically,through the patch on the ankle,we measured the maximum force on the Achilles tendon during jumping which is about 16312 N,which is much higher than that during normal walking(3208 N)and running(5909 N).This work not only provides a strategy for facile monitoring of the variation of the tendon throughout the body but also throws light on the profound comprehension of human activities. | Sheng Shu Jie An Pengfei Chen Di Liu Ziming Wang Chengyu Li Shuangzhe Zhang Yuan Liu Jianzhe Luo Lulu Zu Wei Tang Zhong Lin Wang | 2021 | Research2021，，1： | 0 |
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