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| 1 | Robotic anterior resection of rectal cancer: technique and early outcome显示文摘 | DU Xiao-hui SHEN Di LI Rong LI Song-yan NING Ning ZHAO Yun-shan ZOU Zhen-yu LIU Na | 2013 | Chinese Medical Journal2013，，1： | 15 |
| 2 | Estimation of the Effects of Maize Straw Return on Soil Carbon and Nutrients Using Response Surface Methodology显示文摘Straw incorporation is generally considered an effective agricultural management practice that improves nutrient cycling and maintains soil fertility. To study the interactive effects of straw returning factors on soil organic carbon and available nutrients, a17-month(May 6, 2016 to October 6, 2017) experiment was conducted on straw incorporation by using response surface methodology under a three-factor(straw length, amount, and burying depth), five-level quadratic orthogonal rotation experimental design. Weight was assigned to each indicator for soil carbon and nutrients and then a comprehensive indicator was established. Then, a second-order polynomial model of the three straw returning factors was established using response surface methodology. Results indicated that17 months after straw incorporation, straw amount and burying depth had significant effects on the comprehensive indicator of soil carbon and nutrients. Straw length and the interactions of straw amount and burying depth showed no significant effects on the comprehensive indicator of soil carbon and nutrients. It was concluded that 17 months after straw incorporation, the highest value of the comprehensive indicator of soil carbon and nutrients was achieved when the straw length, amount, and burying depth were approximately 17–20 cm, 740–840 g m^(-2), and 9–13 cm, respectively, which can be recommended as the most suitable parameters for use in straw returning in the study area. | ZHOU Dongxing SU Ye NING Yucui RONG Guohua WANG Guangdong LIU Di LIU Liyan | 2018 | Pedosphere2018，28，3： | 12 |
| 3 | Pedogenic Carbonate and Soil Dehydrogenase Activity in Response to Soil Organic Matter in Artemisia ordosica Community显示文摘Little attention has been paid to the role of soil organic matter (OM) in the formation of pedogenic carbonate in desert soils.The relationships among soil OM,soil dehydrogenase activity (DHA),and soil CaCO 3 in a plant community dominated by Artemisia ordosica,located on the eastern boundary of Tengger Desert in the Alxa League,Inner Mongolia,China,were studied to understand whether OM was directly involved in the formation of pedogenic carbonate.The results showed that DHA and CaCO 3 positively correlated with OM content,and DHA,OM,and CaCO 3 were correlated with each other in their spatial distribution,indicating that abundant OM content contributed to the formation of CaCO 3.Therefore,the formation of pedogenic CaCO 3 was a biotic process in the plant community dominated by A.ordosica. | ZHANG Ning HE Xing-Dong GAO Yu-Bao LI Yong-Hong WANG Hai-Tao MA Di ZHANG Rui S. YANG | 2010 | Pedosphere2010，20，2： | 10 |
| 4 | Fluorescence regional integration and differential fluorescence spectroscopy for analysis of structural characteristics and proton binding properties of fulvic acid sub-fractions显示文摘Structural characteristics and proton binding properties of sub-fractions(FA3–FA13) of fulvic acid(FA), eluted stepwise by pyrophosphate buffer were examined by use of fluorescence titration combined with fluorescence regional integration(FRI) and differential fluorescence spectroscopy(DFS). Humic-like(H-L) and fulvic-like(F-L) materials, which accounted for more than 80% of fluorescence response, were dominant in five sub-fractions of FA. Based on FRI analysis, except the response of F-L materials in FA9 and FA13, maximum changes in percent fluorescence response were less than 10% as pH was increased from 2.5 to 11.5.Contents of carboxylic and phenolic groups were compared for fluorescence peaks of FA sub-fractions based on pH-dependent fluorescence derived from DFS. Static quenching was the dominant mechanism for binding of protons by FA sub-fractions. Dissociation constants(p Ka) were calculated by use of results of DFS and the modified Stern-Volmer relationship. The p Kaof H-L, F-L, tryptophan-like and tyrosine-like materials of FA subfractions exhibited ranges of 3.17–4.06, 3.12–3.97, 4.14–4.45 and 4.25–4.76, respectively, for acidic pHs. At basic pHs, values of p Ka for corresponding materials were in ranges of 9.71–10.24, 9.62–10.99, 9.67–10.31 and 9.33–10.28, respectively. At acidic pH, protein-like(P-L)materials had greater affinities for protons than did either H-L or F-L materials. The dicarboxylic and phenolic groups were likely predominant sites of protonation for both H-L and F-L materials at both acidic and basic pHs. Amino acid groups were significant factors during proton binding to protein-like materials of FA sub-fractions at basic pH. | Fanhao Song Fengchang Wu Weiying Feng Zhi Tang John P.Giesy Fei Guo Di Shi Xiaofei Liu Ning Qin Baoshan Xing Yingchen Bai | 2018 | Journal of Environmental Sciences2018，30，12： | 9 |
| 5 | Clinical characteristics and survival of 5283 esophageal cancer patients: A multicenter study from eighteen hospitals across six regions in China显示文摘Objective:This study aimed to investigate the potential determining epidemiological and clinical risk factors affecting the survival of esophageal cancer(EC)patients across multiple hospitals in China.Methods:This was a multicenter study comprising of newly diagnosed EC cases from Beijing,Hebei,Henan,Hubei,Zhejiang,and Guangdong Province of China.Their baseline characteristics and treatment methods data were collected from their medical records.The EpiData software was used for data quality control.The Kaplan-Meier method was used to estimate their overall survival(OS),and the Cox’s proportional hazard regression model was used to estimate hazard ratios(HR)and 95%confidence interval(CI).Results:The 3-and 5-year OS rates of the 5283 investigated EC patients were 49.98%and 39.07%,respectively.Their median survival was 36.00 months.The median survival time of females was longer than that of males(females vs.males:45.00 vs.33.00,P<0.001).The 5-year OS rate of patients who never-smoked was higher than that of smokers(never-smokers vs smokers:40.73%vs.37.84%,P=0.001).There was no significant difference in the 5-year OS rate between drinkers and never-drinkers(drinkers vs never-drinkers:34.22%vs.29.65%,P=0.330).In multivariate analysis,pathological stage(stage II:HR=1.80,95%CI=1.40-2.31;stage III:HR=2.62,95%CI=2.06-3.34;stage IV:HR=3.90,95%CI=2.98-5.09),poor differentiation/undifferentiated(HR=1.34,95%CI=1.11-1.63),not married status(HR=2.45,95%CI=1.49-4.04),production and service personnel(HR=1.36,95%CI=1.01-1.83)and farming/fishing(HR=1.40,95%CI=1.12-1.76)were independent prognostic risk factors for poor EC survival.Tumors in the thoracic or abdominal part of the esophagus,female and family history of any cancer were independent factors predictive of a good EC OS.Conclusion:Gender,marital status,occupation,family history of any cancer,tumor topographical site,differentiation status,and pathological stage were associated with the survival rate of EC.This study reveals important clinical characteristics of esophageal cancer patients in China and provides helpful information for their clinical management and surveillance. | Yutong He Di Liang Lingbin Du Tiantian Guo Yanyu Liu Xibin Sun Ning Wang Min Zhang Kuangrong Wei Baoen Shan Wanqing Chen | 2020 | Cancer Communications2020，40，10： | 8 |
| 6 | Hepatitis C virus core upregulates the methylation status of the RASSF1A promoter through regulation of SMYD3 in hilar cholangiocarcinoma cells显示文摘增加的证据被积累了在肿瘤开始显示 epigenetic 规定的重要角色。以前,我们观察到病毒核心(HCVc ) 蛋白质导致了的丙肝的 transfection 在正常胆汁的房间的恶意的转变,和那肿瘤 suppressor 基因 RASSF1A 是在由在倡导者区域的 hypermethylation 的许多 hilar cholangiocarcinoma 病人的 downregulated。在现在的学习,我们发现集合和 MYND 包含域的蛋白质 3 (SMYD3 ) ,新奇 histone methyltransferase,在有 HCV 感染的那些特别是在 cholangiocarcinoma 病人的 overexpressed。进 hilar cholangiocarcinoma 房间的 HCVc 的 Transfection 衬里 QBC939 和 FRH0201 能 upregulate SMYD3 的表示并且支持房间生长,它与我们的临床的研究的结果一致。这现象显示 SMYD3 与有 HCV 感染的 cholangiocarcinoma 开始的 epigenetic 规定有关。SMYD3 的 Overexpression 能禁止 RASSF1A 表示,而由 siRNA 的 SMYD3 的抑制改进了它的表示。Methylation 特定的聚合酶链反应(MS-PCR ) 结果证明 RASSF1A 倡导者的 methylation 地位被 SMYD3 调整。在结论, HCVc 能 upregulate 通过 SMYD3 的规定的 RASSF1A 倡导者的 methylation 地位,和 histone methylation 可以由未知机制影响下游的基因的 DNA methylation。 | Ning Guo Rufu Chen Zhihua Li Yonggang Liu Di Cheng Quanbo Zhou Jiajia Zhou Qing Lin | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 8 |
| 7 | LSECtin on tumor-associated macrophages enhances breast cancer sternness via interaction with its receptor BTN3A3显示文摘Macrophages have bee n suggested to con tribute to con structing a cancer stem cell(CSC)niche.However,whether and how macrophages regulate the activity of CSCs through juxtacrine signaling are poorly understood.Here we report LSECtin,a transmembrane protein highly expressed on tumor-associated macrophages(TAMs),enhances sternness of breast cancer cells(BCCs).We identified BTN3A3,a B7 family member with previously unknown functions as the receptor for LSECtin on BCCs responsible for stemness-promoting effect of LSECtin.In mice bearing human tumor xenografts,either macrophage-specific ablation of LSECtin or silencing of BTN3A3 in BCCs decreased CSC frequency and tumor growth.Admixture of LSECtin-positive macrophages increased the tumorigenic activity of BCCs dependent on BTN3A3.Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3 mAb has a therapeutic effect on breast cancer.These findings define a juxtacrine signaling mechanism by which TAMs promote cancer stemness.Targeting this axis in the CSC niche may provide potential therapies to breast cancer. | Di Liu Qian Lu Xing Wang Jun Wang Ning Lu Zefei Jiang Xiaopeng Hao Jianbin Li Jing Liu Pengbo Cao Guilin Peng Yuandong Tao Dianyuan Zhao Fuchu He Li Tang | 2019 | Cell Research2019，29，5： | 8 |
| 8 | Whole-Process Pollution Control for Cost-Effective and Cleaner Chemical Production A Case Study of the Tungsten Industry in China显示文摘In this research,a methodology named whole-process pollution control(WPPC)is demonstrated that improves the effectiveness of process optimization.This methodology considers waste/emission treatment as a step of the whole production process with respect to the minimization of cost and environmental impact for the whole process.The following procedures are introduced in a WPPC process optimization:①a material and energy flow investigation and optimization based on a systematic understanding of the distribution and physiochemical properties of potential pollutants;②a process optimization to increase the utilization efficiency of different elements and minimize pollutant emissions;and③an evaluation to reveal the effectiveness of the optimization strategies.The production of ammonium paratungstate was chosen for the case study.Two factors of the different optimization schemes-namely the cost-effectiveness factor and the environmental impact indicator-were evaluated and compared.This research demonstrates that by considering the nature of potential pollutants,technological innovations,economic viability,environmental impacts,and regulation requirements,WPPC can efficiently optimize a metal production process. | Hongbin Cao He Zhao Di Zhang Chenming Liu Xiao Lin Yuping Li Pengge Ning Jiajun Sun Yi Zhang Zhi Sun | 2019 | Engineering2019，5，4： | 7 |
| 9 | Magnetic resonance imaging with three-dimensional fast imaging employing steady-state acquisition with phase-cycled and short T1 inversion recovery pulse sequence for evaluating brachial plexus injury显示文摘There is a large amount of fat in the postganglionic segment of the brachial plexus nerve.The use of short T1 inversion recovery pulse sequence may improve signal strength of the brachial plexus postganglionic segment.The present study revealed that the combination of three-dimensional fast imaging employing steady-state acquisition with phase-cycled and short T1 inversion recovery pulse sequence clearly displayed the anatomical morphology and structure of the brachial plexus nerve,together with maximum intensity projection,volume rendering and other three-dimensional reconstruction techniques.Our results suggested that this method is also suitable for providing accurate assessment and diagnosis of the site,severity and scope of brachial plexus injury. | Dianxiu Ning Meiyu Sun Bo Sun Li Zhao Weisheng Zhang Lijun Wang Shaowu Wang Ailian Liu Jianlin Wu Zhijin Lang Di Ning Guanfu Liu Xiaochen Ji Xiufeng Wang | 2011 | Neural Regeneration Research2011，6，14： | 7 |
| 10 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 11 | Evolution of secondary phase particles during deformation of Al-5Ti-1B master alloy and their effect on α-Al grain refinement显示文摘Addition of Al-5Ti-1B alloy to molten aluminum alloys can refine α-Al grains effectively and thereby improve their strength and toughness. TiAl_3 and TiB_2 in Al-5Ti-1B alloy are the main secondary-phase particles for refinement, while the understanding on the effect of their sizes on α-Al grain refinement continues to be fragmented. Therefore, Al-5Ti-1B alloys with various sizes and morphologies of the secondary-phase particles were prepared by equal channel angular pressing(ECAP). Evolution of the secondary-phase particles during ECAP process and their impact on α-Al grain refinement were studied by X-ray diffraction and scanning electron microscope(SEM). Results show that during the ECAP process, micro-cracks firstly appeared inside TiAl_3 particles and then gradually expanded, which resulted in continuous refinement of TiAl_3 particles. In addition, micro-distribution uniformity of TiB_2 particles was improved due to the impingement of TiAl_3 particles to TiB_2 clusters during deformation. Excessively large sizes of TiAl_3 particles would reduce the number of effective heterogeneous nucleus and thus resulted in poor grain refinement effectiveness. Moreover, excessively small TiAl_3 particles would reduce inhibitory factors for grain growth Q and weaken grain refinement effectiveness. Therefore, an optimal size range of 18-22 μm for TiAl_3 particles was suggested. | Hong Yu Ning Wang Renguo Guan Di Tie Zheng Li Yanan An Yang Zhang | 2018 | Journal of Materials Science & Technology2018，34，12： | 6 |
| 12 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 13 | Pharmacokinetics of acteoside following single dose intragastric and intravenous administrations in dogs显示文摘Acteoside(verbascoside), a phenylethanoid glycoside widely distributed in various plants, has been shown to have potential activity against Alzheimer's disease, attracting great attentions recently. The present study was designed to develop a selective and sensitive LC-MS/MS method for the determination of acteoside in biological samples and carry our a phamacokinetic(PK) study in beagle dogs. The PK parameters were calculated using non-compartmental models. Following a single-dose oral administration, acteoside was rapidly absorbed and eliminated, with Tmax being between 30 to 45 min and terminal half-life being about 90 min. The areas under the time-concentration curve(AUC) were 47.28 ± 8.74, 87.86 ± 13.33, and 183.14 ± 28.69 mg·min·L-1 for oral administration of 10, 20, and 40 mg·kg-1, respectively, demonstrating that the exposure of acteoside proportionally increased with the dose level. The absolute bioavailability of acteoside was around 4%. For all the PK parameters, there were large variations between individual dogs. In conclusion, the pharmacokinetic characteristics observed in the present study can be of great value to help better understand the pharmacological properties of acteoside and to improve the outcome of its clinical use. | ZHANG Wei HUO Shi-Xia WEN Yan-Li XING Han ZHANG Qing LI Ning ZHAO Di SUN Xiao-Lin XU Jie YAN Ming CHEN Xi-Jing | 2015 | Chinese Journal of Natural Medicines2015，13，8： | 5 |
| 14 | Credit-based scheme for security-aware and fairness-aware resource allocation in cloud computing显示文摘Cloud computing systems include different types of participants with varied requirements for resources and multiple tasks; these varying requirements must be considered in the design of fairness-aware resource allocation schemes for better resources sharing. However, some participants may be malicious with a goal to damage the resource allocation fairness and increase their own utility. Hence, the resource scheduling policy must guarantee allocation fairness among the participants; further, it must ensure that fairness is not affected by the malicious usage of resources, that could cause resource exhaustion and lead to denial of service. In order to address this challenge, we propose a credit-based mechanism for resource allocation that will avoid the malicious usage of resources and, simultaneously, guarantee allocation fairness. In our scheme, a credit factor is introduced for each participant in order to evaluate the history of resource utilization and determine future resource allocation. Our model encourages a participant to release the occupied resources in timely manner after the completion of a task and imposes a punishment for malicious occupation of resources. We prove the fairness of our model and provide linear and variable gradient approaches to determine the credit factor for different scenarios. We simulate our model and perform experiments on a real cloud computing platform. The results prove the rationality, effectiveness and correctness of our approaches. | Di LU Jianfeng MA Cong SUN Xindi MA Ning XI | 2017 | Science China(Information Sciences)2017，60，5： | 4 |
| 15 | Daphnane Diterpenoids from Trigonostemon lii and Inhibition Activities Against HIV‑1显示文摘Natural products are the important source for the discovery of more potent anti-HIV agents.In this study,six daphnane diterpenoids including three unreported structures were isolated from Trigonostemon lii,which showed signifcant activities against HIV-1 strains replication in the nanomolar/picomolar range.Meanwhile,these diterpenoids signifcantly inhibited the fusion of H9/HIV-1 IIIB cells with uninfected C8166 cells,with the EC50s from 1.06 to 8.73 ng/mL,and did not show any inhibition activities against HIV-1 reverse transcriptase.Moreover,all of the diterpenoids shows signifcant inhibitions against T20-resistan HIV-1 strains,PNL4-3gp41(36G)V38E,N42S and pNL4-3gp41(36G)V38A,N42T.The results revealed that the six diterpenoids could be a new type of potential lead candidate as an HIV entry inhibitor,particularly for those infected by T20-resistant variants. | Cheng-Jian Tan Shi-Fei Li Ning Huang Yu Zhang Ying-Tong Di Yong-Tang Zheng Xiao-Jiang Hao | 2020 | Natural Products and Bioprospecting2020，10，1： | 4 |
| 16 | A preliminary study of impact of reduced system inertia in a low-carbon power system显示文摘One of the important features of low-carbon electric power system is the massive deployment of renewable energy resources in the advent of a new carbon-strained economy.Wind generation is a major technology of generating electric power with zero carbon dioxide emission.In a power system with the high penetration of wind generation,the displacement of conventional synchronous generators with variable speed wind turbines reduces system inertia.This leads to larger system frequency deviation following a loss of large generation.In this paper,the impact of the reduction of system inertia on system frequency is analyzed as the result of the integration of a significant amount of wind generation into power systems.Furthermore,we present a preliminary study of the impact of the distribution of the inertia contributions from those online conventional synchronous generators on the rate of change of frequency(ROCOF)based on the total energy injected into the system due to the fault.The total fault energy is represented using Hamiltonian formulism.With the IEEE 39-bus system,it is shown that for a fault with the given injected total energy,clearing time,and location,the distribution of inertia contributions can significantly affect the magnitude of ROCOF.Moreover,for such a fault with different locations,the average of the magnitudes of ROCOF caused by the fault at different locations is larger when the distribution of the inertia contributions is more dispersed. | Di WU Milad JAVADI John Ning JIANG | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，1： | 4 |
| 17 | Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation显示文摘The potential medicinal value of Ma bamboo(Dendrocalamus latiflorus), one of the most popular and economically important bamboo species in China, has been underestimated. In the present study, we found that D. latiflorus leaf extract(DLE) reduced fasting blood glucose levels, body weight,and low-density lipoprotein cholesterol with low liver toxicity in db/db mice. In addition, gene expression profiling was performed and pathway enrichment analysis showed that DLE affected metabolic pathways.Importantly, DLE activated the AKT signaling pathway and reduced glucose production by downregulating glucose-6-phosphatase(G6 PC) and phosphoenolpyruvate carboxykinase 1(PCK1) expression. Moreover, network pharmacology analysis identified rutin as an active component in DLE through targeting insulin growth factor 1 receptor(IGF1 R), an upstream signaling transducer of AKT. Due to its hypoglycemic effects and low toxicity, DLE may be considered an adjuvant treatment option for type 2 diabetes patients. | Kun Luo Wenting Huang Liansheng Qiao Xiaoling Zhang Di Yan Zhiyu Ning Chengmei Ma Honglei Dang Dong Wang Hongyan Guo Lan Xie Jing Cheng | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 18 | Clinical Analysis of 10 AIDS Patients with Malignant Lymphoma显示文摘Objective This work summarizes the clinical features and treatment of 10 AIDS patients with malignant lymphoma. Methods A total of 10 AIDS patients with malignant lymphoma seen in Beijing Ditan Hospital since 2009 were enrolled.Clinical manifestations,pathological examinations,immunity levels,Epstein-Barr virus antibody examinations,complications,treatments,and outcomes were retrospectively analyzed. Results The main clinical manifestations of these patients included intermittent fever in 2 cases,neck masses and fever in 3 ases,auxiliary lymph node enlargement in 2 cases,and abdominal pain and bloating with fever in 3 cases.Up to 7 patients were pathologically diagnosed with diffuse large B cell lymphoma(DLBCL),and 3 patients were pathologically diagnosed with Burkitt’s lymphoma.Up to 8 patients had CD4 cell counts below 200/uL,and 2 patients had a level of more than 200/μL.Up to 7 patients were negative for EBV-IgM antibodies and 3 patients were not examined.Six patients underwent different chemotherapy and their prognoses were different.One patient with Burkitt’s lymphoma alternatively took CODOXM and IVAC for 3 turns after VP chemotherapy;1 patient with liver metastasis took R-CHOP 5 times,then changed therapy regimen to R-MINE and MINE. One patient with adrenal DLBCL took CHOP 6 times.Three patients with DLBCL took CHOP 1 or 2 times.Four patients gave up treatment.Various infections and side effects occurred,including bone marrow suppression,gastrointestinal bleeding,and renal (?)stunction during chemotherapy.Six patients took HAART,and 4 did not.Six patients died,whereas 3 patients got improved;and 1 (?)atient was discharged. (?)clusions AIDS patients with malignant lymphoma had various clinical manifestations,were immunocompromised,and had (?)e metastases when they were admitted;they were already in the interim or late stage of lymphoma.Chemotherapy was not (?)tive,and additional complications occurred.HAART failed to improve patient prognosis,and the overall prognosis was poor. | Gui-ju Gao Di Yang Ke-ke Lin Jiang Xiao Xin Li Hong-yuan Liang Long Liu Ning Han Hong-xin Zhao | 2012 | Clinical oncology and cancer resexreh2012，9，2： | 4 |
| 19 | Fatigue Property of Low Cost and High Strength Wheel Steel for Commercial Vehicle显示文摘The fatigue properties of the newly developed wheel steel used for commercial vehicles were studied using push-pull axial loading fatigue tests with stress ratio R=-1.Q235B steel,which is conventionally applied to commercial vehicle wheels,was also analyzed for comparison.Although the chemical composition and microstructure(ferrite and pearlite) of newly developed wheel steel were similar to those of Q235B,the 107 cycles fatigue limit of the new wheel steel was 260 MPa,which is 24% higher than that of Q235B(210 MPa).The improvement of the fatigue strength of the new wheel steel can be attributed to grain refinement.In order to investigate the effect of the decrease in thickness of the wheel steel on the fatigue property of the wheel,dynamic cornering fatigue tests were conducted on full scale wheels with the model of 8.25×22.5.The results indicated that the newly developed wheel steel had outstanding fatigue life even if the mass loss was 10% in comparison with Q235B. | WANG Ning LI Yi DU Lin-xiu WU Di LIU Xiang-hua | 2009 | Journal of Iron and Steel Research(International)2009，16，4： | 3 |
| 20 | APPLET:a privacy-preserving framework for location-aware recommender system显示文摘Location-aware recommender systems that use location-based ratings to produce recommendations have recently experienced a rapid development and draw significant attention from the research community.However, current work mainly focused on high-quality recommendations while underestimating privacy issues,which can lead to problems of privacy. Such problems are more prominent when service providers, who have limited computational and storage resources, leverage on cloud platforms to fit in with the tremendous number of service requirements and users. In this paper, we propose a novel framework, namely APPLET, for protecting user privacy information, including locations and recommendation results, within a cloud environment. Through this framework, all historical ratings are stored and calculated in ciphertext, allowing us to securely compute the similarities of venues through Paillier encryption, and predict the recommendation results based on Paillier,commutative, and comparable encryption. We also theoretically prove that user information is private and will not be leaked during a recommendation. Finally, empirical results over a real-world dataset demonstrate that our framework can efficiently recommend POIs with a high degree of accuracy in a privacy-preserving manner. | Xindi MA Hui LI Jianfeng MA Qi JIANG Sheng GAO Ning XI Di LU | 2017 | Science China(Information Sciences)2017，60，9： | 3 |
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