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| 1 | Current pattern of Chinese dialysis units: a cohort study in a representative sample of units显示文摘 | ZHOU Qiu-gen JIANG Jian-ping WU Sheng-jie TIAN Jian-wei CHEN Jiang-hua YU Xue-qing CHEN Ping-yan MEI Chang-lin XIONG Fei SHI Wei ZHOU Wei LIU Xu-sheng SUN Shi-ren XIE Di LIU Jun XU Xin HOU Fan-fan | 2012 | Chinese Medical Journal2012，，19： | 69 |
| 2 | Spatial-temporal Characteristics of Land Use Intensity of Coastal Zone in China During 2000–2010显示文摘Based on remote sensing and GIS techniques, land use maps in 2000, 2005 and 2010 in China′s coastal zone were produced, and structural raster data of land use were further generated to calculate land use intensity comprehensive index(LUICI) for analyzing land use spatial-temporal characteristics at 1 km scale. Results show that: 1) from the perspective of spatial patterns of landforms at a macro scale, there is a significant difference in land use intensity between the north and the south of China′s coastal zone. Hotspots of changes mainly concentrated in metropolitan areas, estuaries and coastal wetlands; 2) elevation is an important factor that controlling land use spatial patterns at local scale. Land use intensity is much higher within areas below the elevation of 400 m and it decreased significantly as the elevation increasing; 3) there is a significant land-ocean gradient for land use intensity, which is low in island and near-shore areas, but high in the regions that 4–30 km far away the coastline because of much intensive human activities; however, in recent decades land use intensity had been promoted significantly in low near-shore area due to extensive sea reclamations; 4) significant differences of land use intensity were also found among provincial administrative units. A rising trend of land use intensity was found in provincial-level administrative units from 2000 to 2010. To sum up, elevation, land-ocean gradient, socio-economic status and policy are all influencing factors to the spatial patterns and temporal variations of land use intensity in China′s coastal zone. | DI Xianghong HOU Xiyong WANG Yuandong WU Li | 2015 | Chinese Geographical Science2015，25，1： | 20 |
| 3 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 4 | Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection显示文摘T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However,whether Tim-3 is involved in hepatitis B virus(HBV) infection remains unknown. Here,we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes,especially on CD8+ T cells,was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs,significantly increased IFN-γ production from hepatic CD8+ T cells in HBV model mice was observed. Very interestingly,we found Tim-3 expression on CD8+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover,Tim-3 knockdown influenced anti-HBs production in vivo. Collectively,our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. | Ying Ju Nan Hou Xiaoning Zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining Zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma | 2009 | Cellular & Molecular Immunology2009，6，1： | 19 |
| 5 | Ultralong-life and high-rate web-like Li4Ti5O12 anode for high-performance flexible lithium-ion batteries显示文摘 | Xianfu Wang Bin Liu Xiaojuan Hou Qiufan Wang Wenwu Li Di Chen Guozhen Shen | 2014 | Nano Research2014，7，7： | 16 |
| 6 | Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application显示文摘The insufficient osteogenesis and osseointegration of porous titanium based scaffold limit its further application.Early angiogenesis is important for scaffold survival.It is necessary to develop a multifunctional surface on titanium scaffold with both osteogenic and angiogenic properties.In this study,a biofunctional magnesium coating is deposited on porous Ti6Al4V scaffold.For osseointegration and osteogenesis analysis,in vitro studies reveal that magnesium-coated Ti6Al4V co-culture with MC3T3-E1 cells can improve cell proliferation,adhesion,extracellular matrix(ECM)mineralization and ALP activity compared with bare Ti6Al4V cocultivation.Additionally,MC3T3-E1 cells cultured with magnesium-coated Ti6Al4V show significantly higher osteogenesisrelated genes expression.In vivo studies including fluorochrome labeling,micro-computerized tomography and histological examination of magnesium-coated Ti6Al4V scaffold reveal that new bone regeneration is significantly increased in rabbits after implantation.For angiogenesis studies,magnesium-coated Ti6Al4V improve HUVECs proliferation,adhesion,tube formation,wound-healing and Transwell abilities.HUVECs cultured with magnesium-coated Ti6Al4V display significantly higher angiogenesis-related genes(HIF-1αand VEGF)expression.Microangiography analysis reveal that magnesium-coated Ti6Al4V scaffold can significantly enhance the blood vessel formation.This study enlarges the application scope of magnesium and provides an optional choice to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and angiogenesis for further orthopedic applications. | Peng Gao Bo Fan Xiaoming Yu Wenwen Liu Jie Wu Lei Shi Di Yang Lili Tan Peng Wan Yulin Hao Shujun Li Wentao Hou Ke Yang Xiaokang Li Zheng Guo | 2020 | Bioactive Materials2020，5，3： | 15 |
| 7 | Advanced oxidation protein products decrease expression of nephrin and podocin in podocytes via ROS-dependent activation of p38 MAPK显示文摘Accumulation of plasma advanced oxidation protein products(AOPPs) promotes progression of proteinuria and glomerulo-sclerosis.To investigate the molecular basis of AOPPs-induced proteinuria,normal Sprague-Dawley rats were treated with AOPPs-modified rat serum albumin.The expression of glomerular podocyte slit diaphragm(PSD)-associated proteins,nephrin and podocin,was significantly decreased coincident with the onset of albuminuria in rats treated with AOPPs.Chronic inhibi-tion of NADPH oxidase by apocynin prevented down-regulation of nephrin and podocin and decreased albuminuria in AOPPs-challenged rats.This suggested that accumulation of AOPPs promotes proteinuria,possibly via down-regulating the expression of PSD-associated proteins. | YANG Li,LIANG Min,ZHOU QiuGen,XIE Di,LOU AiJu,ZHANG Xun & HOU FanFan Key Laboratory for Organ Failure Research,Division of Nephrology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China. | 2010 | Science China(Life Sciences)2010，53，1： | 14 |
| 8 | Advanced rechargeable lithium-ion batteries based on bendable ZnCo2O4-urchins-on-carbon-fibers electrodes显示文摘ZnCo2O4-urchins-on-carbon-fibers 矩阵的一个新奇的班被设计了,描绘,并且过去常制作高效的精力存储设备。我们获得了 1180 妈数慲畴敲 ?L 癯 ? ㈱? 的一个可逆的锂存储能力 ?? 牣慥楳杮倠 ? 挠湯整瑮 ?? 桳牯 ? 整浲 ??? 琠敨浲污琠敲瑡敭瑮 ? 瑡 ??? 鲖 ? 栀氠睯牥愠摮甠灰牥焠慵瑮汩獥映牯搠楡祬洠湩浩浵琠浥数爔?爔 吗?? | Bin Liu Xianfu Wang Boyang Liu Qiufan Wang Dongsheng Tan Weifeng Song Xiaojuan Hou Di Chen Guozhen Shen | 2013 | Nano Research2013，6，7： | 10 |
| 9 | Late recurrent high degree atrioventricular block after percutaneous closure of a perimembranous ventricular septal defect显示文摘高度心房与心室的块(HDAVB ) 是 perimembranous 的 transcatheter 闭合的严肃的复杂并发症室的氏族的缺点(PMVSD ) 。我们报导开发了短暂 HDAVB 的一个病人在在过程以后的 PMVSD 和有的周期性的 HDAVB 42 月的 transcathter 闭合以后的七天。 | YANG Rong SHENG Yan-hui CAO Ke-jiang ZOU Jiang-gang ZHANG Hao HOU Xiao-feng XU Di YONG Yong-hong ZHOU Lei KONG Xiang-qing | 2011 | Chinese Medical Journal2011，，19： | 8 |
| 10 | Crystalline Silica Promotes Rat Fibrocyte Differentiation in Vitro,and Fibrocytes Participate in Silicosis in Vivo显示文摘Objective The aim of this study was to investigate the effects of Si O2 on fibrocytes and whether fibrocytes participate in silicosis in vivo. Methods A macrophagocyte(AM)/fibrocyte coculture system was established, and AMs were treated with 100 μg/mL SiO 2. Flow cytometry was used to detect the number of fibrocytes. Real‐time PCR was performed to measure the expression of collagen I, collagen III, and α‐SMA mR NA. The levels of collagen I, collagen III, and TGF‐β1 protein were determined by ELISA. Immunohistochemical staining was performed to measure α‐SMA protein expression. A rat silicosis model was induced by intratracheal instillation of SiO 2. Lung histopathological evaluation was conducted using HE and Masson's trichrome staining after 1 and 9 weeks. The number of fibrocytes in peripheral blood or lung tissue of rat was detected by flow cytometry. Double‐color immunofluorescence was applied to identify fibrocytes in the lung tissue. Results Peripheral blood monocytes were found to differentiate into fibrocytes in vitro in a time‐dependent manner, and exposure to crystalline silica might potentiate fibrocyte differentiation. In addition, fibrocytes were able to migrate from peripheral blood to the lung tissue, and the number of fibrocytes was increased after SiO 2 exposure. Conclusion Silica exposure potentiates fibrocyte differentiation, and fibrocytes may participate in silicosis in vivo. | LI Juan YAO Wu HOU Jian Yong Zhang Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao HAO Chang Fu | 2017 | Biomedical and Environmental Sciences2017，30，9： | 7 |
| 11 | Literature review and analysis of the development of health outcomes assessment instruments in Chinese medicine显示文摘OBJECTIVE: To evaluate the development of health outcomes assessment instruments in Chinese medicine. METHODS: A comprehensive literature search for all published articles in China National Knowledge Infrastructure Database, Chongqing VIP Database and WANFANG Data was conducted. The studies that met the inclusion and exclusion criteria were used to extract information according to a predesigned assessment instrument. RESULTS: A total of 97 instruments for health outcome assessment in Chinese medicine were identified. Of these questionnaires, 7 were generic, 12 were condition-specific and 78 were disease-specific. All instruments were suitable for adults, children, and both men and women. These instruments aimed to evaluate the health-related quality of life, signs and symptoms as well as patient satisfaction and doctor-reported outcome. However, the descriptions were poorly constructed for some of the most basic parameters, such as the domains and items, administrative mode, response options, memory recall periods, burden evaluation, format, copyright, content validity, and other properties. CONCLUSION: The instrument development for health outcomes assessment in Chinese medicine is increasing rapidly; however, there are many limitations in current methodologies and standards, and further studies are needed. | Feng-bin Liu Zheng-kun Hou Yun-ying Yang Zheng-zheng Zhang Di Xie Nelson Xie Hong Thach Nguyen | 2013 | Journal of Integrative Medicine2013，11，2： | 7 |
| 12 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 13 | Validation and application of water levels derived from Sentinel-3A for the Brahmaputra River显示文摘For the first time ever, this study aims at applying Sentinel-3 A to the Great Brahmaputra River(GBR) and validating water levels derived from this newly-launched altimetry satellite mission. The GBR is divided into three primary parts:(1) a large section of the Yarlung Zangbo River in China, also termed the Upper Brahmaputra River(UBR) in this study, featured by high elevation,complex terrain, narrow river widths(from less than 100 to 400 m), and limited in situ measurements;(2) the Middle Brahmaputra River(MBR) with widths varying from ~400 m to ~1 km;(3) the Lower Brahmaputra River(LBR), dominated by braided channels with wide river channels(up to several kilometers). For the altimetry data, both waveform retracking and hooking effect correction were applied to mitigate the influence caused by land contamination and to improve the accuracy of water level retrievals. Water levels were derived from 41 virtual stations(VSs) across the GBR and different retracking algorithms were compared with in situ data from two gauging stations in the UBR. Time series of altimetry-based water levels were categorized into three types based on the quality: no data(type 1), degraded(type 2), and good(type 3). Results showed that the VSs(type 1) only existed in the mountainous regions, accounting for ~ a half of the total in the UBR. Validation with the gauged water levels showed that the TIC algorithm performed best among all of the retrackers applied, followed by the Ice-1 algorithm. The standard deviation of the difference between the gauged and TIC-derived water levels ranged from 0.41 to 0.76 m among four different VSs(type 3). In addition, the quality of VSs in the LBR was best, followed by the MBR. Our study has demonstrated the capability of Sentinel-3 A in monitoring water levels in the GBR, thereby paving the way for future applications such as discharge estimation and hydrologic/hydrodynamic applications. | HUANG Qi LI XingDong HAN PengFei LONG Di ZHAO FanYu HOU AiZhong | 2019 | Science China(Technological Sciences)2019，62，10： | 6 |
| 14 | An improved modeling of precipitation phase and snow in the Lancang River Basin in Southwest China显示文摘Precipitation phase(e.g., rainfall and snowfall) and snow(e.g., snowpack and snowmelt runoff) in high-mountain regions may largely affect runoff generation, which is critical to water supply, hydropower generation, agricultural irrigation, and ecosystems downstream. Accurately modeling precipitation phase and snow is therefore fundamental to developing a better understanding of hydrological processes for high-mountain regions and their lower reaches. The Lancang River(LR, or the Upper Mekong River)in China, among the most important transboundary rivers originating from the Tibetan Plateau, features active dam construction and complex water resources allocation of various stakeholders in Southeast Asian countries under climate change. This study aims to improve precipitation phase and snow modeling for the LR basin with a hydrological model and multisource remotely sensed data. Results show that joint use of the Moderate Resolution Imaging Spectroradiometer(MODIS) land surface temperature product with high spatial resolution(1 km×1 km) and an air temperature product can more precisely distinguish precipitation phase than air and wet-bulb temperature products in the LR basin. Snowfall and snowmelt were found to be controlled primarily by rainfall and snowfall temperature thresholds in snow modeling. The rainfall and snowfall temperature thresholds derived from the hydrological model through calibration with remotely sensed snowpack at basin scales were considerably lower than those derived from in situ observations. Rainfall and snowfall temperature thresholds derived from in situ observations could lead to the overestimation of snowmelt runoff due mostly to the lack of representation of point-based measurements at basin scales. This study serves as a basis for better modeling and predicting snow for the LR basin and potentially other similar basins globally. | HAN ZhongYing LONG Di HAN PengFei HUANG Qi DU MingDa HOU AiZhong | 2021 | Science China(Technological Sciences)2021，64，7： | 6 |
| 15 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 16 | nduction of M2-1ike macrophages in recipient NOD-scid mice by allogeneic donor CD4+CD25+ regulatory T cells显示文摘CD4 + 规章的 T 细胞(Tregs ) 玩的 CD25 + 在经由显型的规定和天生、适应的有免疫力的细胞的功能维持宿主免疫者忍耐的一个重要角色。是否 allogeneic CD4 + CD25 + Tregs 能调整接受者老鼠巨噬细胞是未知的。allogeneic 施主 CD4 + 接受者老鼠居民 F4/80 ++ Tregs > 巨噬细胞用在的一个老鼠模型被调查 allogeneic 施主 CD4 + CD25 + Tregs 采纳地被变成主人 NOD-scid 老鼠的腹洞。接受者巨噬细胞的显型和功能当时是 assayed。在收到了 allogeneic CD4 ++巨噬细胞> CD25 + Tregs 显著地表示了 CD23 的高水平并且规划了房间 death-ligand 1 ( PD-L1 )并且 CD80 的底层, CD86 ,与收到了任何一个 allogeneic CD4 + CD25 − T 房间( Teffs )或没有房间。接受者老鼠的居民 F4/80 + 巨噬细胞与 allogeneic 施主 CD4 + 显著地显示的 CD25 + Tregs 和增加的 IL-10 生产增加了鸡红血房间(cRBCs ) 和 arginase 活动的吞噬作用,而这些巨噬细胞也显示出减少的 immunogenicity 和氮的氧化物(没有) 生产。部分,但是显著地堵住 arginase 颠倒了 CD4 + 关于在 vivo 的 M2 巨噬细胞的正式就职的 CD25 + Tregs。因此, allogeneic 施主 CD4 + CD25 + Tregs 能经由一条 arginase 小径部分地至少在接受者老鼠导致 M2 巨噬细胞。我们在 vivo 证据提供了支持由的未知小径 allogeneic 施主 CD4 + CD25 + Tregs 由支持 M2 巨噬细胞的区别在接受者老鼠调整天生的豁免。 | Xuelian Hu Guangwei Liu Yuzhu Hou Jianfeng Shi Linnan Zhu Di Jin Jianxia Peng Yong Zhao | 2012 | Cellular & Molecular Immunology2012，9，6： | 5 |
| 17 | Automatic analytical approach for the determination of 12 illicit drugs and nicotine metabolites in wastewater using on-line SPE-UHPLC-MS/MS显示文摘In this study,we developed a novel on-line solid phase extraction(SPE)-ultra-high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)-based analytical method for simultaneously quantifying 12 illicit drugs and metabolites(methamphetamine,amphetamine,morphine,codeine,6-monoacetylmorphine,benzoylecgonine,3,4-methylenedioxymethamphetamine,3,4-methylenedioxyamphetamine,cocaine,ketamine,norketamine,and methcathinone)and cotinine(COT)in wastewater samples.The analysis was performed by loading 2 m L of the sample onto an Oasis hydrophilic-lipophilic balance cartridge and using a cleanup step(5%methanol)to eliminate interference with a total run time of 13 min.The isotope-labeled internal standard method was used to quantify the target substances and correct for unavoidable losses and matrix effects during the on-line SPE process.Typical analytical characteristics used for method validation were sensitivity,linearity,precision,repeatability,recovery,and matrix effects.The limit of detection(LOD)and limit of quantification(LOQ)of each target were set at 0.20 ng/L and 0.50 ng/L,respectively.The linearity was between 0.5 ng/L and250 ng/L,except for that of COT.The intra-and inter-day precisions were<10.45%and 25.64%,respectively,and the relative recovery ranged from 83.74%to 162.26%.The method was used to analyze various wastewater samples from 33 cities in China,and the results were compared with the experimental results of identical samples analyzed using off-line SPE.The difference rate was between 19.91%and-20.44%,and the error range could be considered acceptable.These findings showed that on-line SPE is a suitable alternative to off-line SPE for the analysis of illicit drugs in samples. | Jingyuan Wang Likai Qia Chenzhi Hou Tingting Zhang Mengyi Chen Haitao Meng Mengxiang Su Hui Xu Zhendong Hua Youmei Wang Bin Di | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 5 |
| 18 | Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model显示文摘Chaperone-mediated autophagy(CMA)is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative diseases.However,the mechanisms that regulate CMA are not fully understood.Here,using unbiased drug screening approaches,we discover Metformin,a drug that is commonly the first medication prescribed for type 2 diabetes,can induce CMA.We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKα/β signaling that leads to phosphorylation of Ser85 of the key mediator of CMA,Hsc70,and its activation.Notably,we find that amyloid-beta precursor protein(APP)is a CMA substrate and that it binds to Hsc70 in an IKKα/β-dependent manner.The inhibition of CMA-mediated degradation of APP enhances its cytotoxicity.Importantly,we find that in the APP/PS1 mouse model of Alzheimer's disease(AD),activation of CMA by Hsc70 overexpression or Metformin potently reduces the accumulated brain Aβplaque levels and reverses the molecular and behavioral AD phenotypes.Our study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKα/β-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases,such as AD,where such therapeutic intervention could be beneficial. | Xiaoyan Xu Yaqin Sun Xufeng Cen Bing Shan Qingwei Zhao Tingxue Xie Zhe Wang Tingjun Hou Yu Xue Mengmeng Zhang Di Peng Qiming Sun Cong Yi Ayaz Najafov Hongguang Xia | 2021 | Protein & Cell2021，12，10： | 5 |
| 19 | A comparative study of hydrothermal aging effect on cerium and lanthanum doped Cu/SSZ-13 catalysts for NH_(3)-SCR显示文摘Ce-or La-doped Cu/SSZ-13 catalysts were prepared by a hydrothermal method and Cu,Ce or La ions were incorporated through stepwise ion exchange,The catalyst activity was measured for the ammonia selective catalytic reduction reaction.The structure and composition of catalyst were characterized by using X-ray diffraction,scanning electron microscopy,inductively coupled plasma mass spectrometry solid-state NMR,NH_(3)-TPD techniques,and the active components were examined by XPS and XANES.The results indicate that the Ce and La doping can both completely preserve the SCR activity of Cu/SSZ-13 above 300℃,but there is also a decrease of activity below 200℃.On the other hand,Ce doping is beneficial to the formation of framework aluminum,stabilizes molecular sieve framework and Cu active sites of Cu/SSZ-13,thereby improves the catalyst hydrothermal stability.But La doping will decrease the amount of framework aluminum and Cu active sites of Cu/SSZ-13 after hydrothermally aging,even destroy zeolite CHA structure.This is quite harmful to the catalyst hydrothermal stability. | Di Deng Shujun Deng Dandan He Zhiheng Wang Zhipeng Chen Yi Ji Guoping Yan Guangjin Hou Licheng Liu Hong He | 2021 | Journal of Rare Earths2021，39，8： | 5 |
| 20 | The fundamental performance of FAST with 19-beam receiver at L band显示文摘The Five-hundred-meter Aperture Spherical radio Telescope(FAST) has passed national acceptance and finished one pilot cycle of ‘Shared-Risk’ observations. It will start formal operation soon. In this context, this paper describes testing results of key fundamental parameters for FAST, aiming to provide basic support for observation and data reduction of FAST for scientific researchers. The 19-beam receiver covering 1.05–1.45 GHz was utilized for most of these observations. The fluctuation in electronic gain of the system is better than 1% over 3.5 hours, enabling enough stability for observations. Pointing accuracy,aperture efficiency and system temperature are three key parameters for FAST. The measured standard deviation of pointing accuracy is 7.9′′, which satisfies the initial design of FAST. When zenith angle is less than 26.4°, the aperture efficiency and system temperature around 1.4 GHz are ~0.63 and less than 24 K for central beam, respectively. The sensitivity and stability of the 19-beam backend are confirmed to satisfy expectation by spectral HI observations toward NGC 672 and polarization observations toward 3 C 286. The performance allows FAST to take sensitive observations for various scientific goals, from studies of pulsars to galaxy evolution. | Peng Jiang Ning-Yu Tang Li-Gang Hou Meng-Ting Liu Marko Krco Lei Qian Jing-Hai Sun Tao-Chung Ching Bin Liu Yan Duan You-Ling Yue Heng-Qian Gan Rui Yao Hui Li Gao-Feng Pan Dong-Jun Yu Hong-Fei Liu Di Li Bo Peng Jun Yan FAST Collaboration | 2020 | Research in Astronomy and Astrophysics2020，20，5： | 5 |
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