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| 1 | Persistent alanine aminotransferase elevation among the general Iranian population: Prevalence and causes显示文摘AIM: To determine the prevalence and causes of persistently elevated alanine aminotransferase (ALT) levels among the general population in northern Iran. METHODS: A total of 2292 (1376 female, aged 18-75 year), were selected by systematic clustered random sampling from the cities and villages of Gonbad and Kalaleh in Golestan Province and invited to participate in the study. A comprehensive history regarding alcohol drinking and medication was taken. Body mass index (BMI), viral markers and ALT levels were measured. If ALT level was ≥ 40 U/L, it was rechecked twice within 6 mo. Those with ≥ 2 times elevation of ALT were considered as having persistently elevated ALT level. Non-alcoholic fatty liver disease (NAFLD) was diagnosed based on evidence of fatty liver upon sonography and excluding other etiology. RESULTS: A total of 2049 (1351 female) patients participated in the study, 162 (7.9%) had elevated ALT level at the first measurement. Persistently elevated ALT level was detected in 64 (3.1%) participants, with51 (79.6%) with no obvious etiology, six (9.3%) with Hepatitis B, four (6.2%) with Hepatitis C virus (HCV) infection and three (4.6%) with alcoholic hepatitis. The prevalence of NAFLD and alcoholic hepatitis was 2.04% (42 patients) and 0.1% (three), respectively. There was correlation between NAFLD and male gender, overweight, diabetes and living in an urban area [odds ratio = 3.03 (95% CI: 1.6-5.72), 4.21 (95% CI: 1.83-9.68), 2.86 (95% CI: 1.05-7.79) and 2.04 (95% CI: 1.00-4.16) respectively]. CONCLUSION: NAFLD is the most common cause of persistently elevated serum ALT level among the general population of Iran. | Raika Jamali Mahmoodreza Khonsari Shahin Merat Masoud Khoshnia Elham Jafari Alireza Bahram Kalhori Hassan Abolghasemi Sedighe Amini Mahtab Maghsoudlu Mohammad Reza Deyhim Houri Rezvan Akram Pourshams | 2008 | World Journal of Gastroenterology2008，14，18： | 7 |
| 2 | The effects ofestrogen depletion and isoflavones on bone metabolism in rats显示文摘 | DEYHIM F STOECKER B J BRUSEXITZ G H | 2003 | Nutri-tion Research2003，23，1： | 1 |
| 3 | Ipriflavone modulates IGF-I but is unable to restore bone in rats显示文摘 | Deyhim F Smith BJ Soung DY | | 0，，02： | 1 |
| 4 | A revaluation of the male broilers riboflavin and pantothenic acid dietary requirement in thermoneutral and heat distress environment显示文摘 | Deyhim F Wiernuse C J Belay T | 1992 | Poultry Sci1992，，： | 1 |
| 5 | The effect of heat distress environment, vitamin, and trace mineral supplementation on performance, blood constituents, and tissue mineral concentration in broiler chickens 显示文摘 | Deyhim F Stoecker B S Adeleye B G | 1995 | Nutrition Research1995，15，4： | 1 |
| 6 | Comparison of day five acclimation and fasting techniques to reduce broiler heat distress mortality 显示文摘 | McDONAL K BELAY T DEYHIM F | 1990 | Annu Rep Okla Agric Exp Stn1990，6，129： | 1 |
| 7 | Effects of isoflavone on mice bone显示文摘 | Deyhim Farzad Barbara J Stoecker Gerald H Brusewitz | 2003 | Nutrition Research2003，23，： | 1 |
| 8 | Dried plum reverses bone loss in an osteopenic rat model of osteoporosis 显示文摘 | DEYHIM F STOECKER B J BRUSEWITZ G H | 2005 | Menopause2005，12，6： | 1 |
| 9 | Comparison of day five acclimation and fasting techniques to reduce broiler heat distress mortality显示文摘 | Belay T Deyhim F | 1990 | Annu Rep Okla Agric Exp Stn1990，6，129： | 1 |
| 10 | Effect of heat stress and drinking water salt supplements on plasma electrolytes and aldosterone concentration in broiler chickens显示文摘 | DEYHIM F TEETER R G | 1995 | J Biometeoro11995，38，4： | 1 |
| 11 | Effect of heat stress and drinking water salt supp laments on plasma electrolytes and aldosterone concentration in broiler chickens显示文摘 | Deyhim F Teeterr G | 1995 | J Biometeorol1995，38，4： | 1 |
| 12 | An evaluationof dietary pantothenic acid needs of broilers througheight weeks posthatching 显示文摘 | DEYHIM F BELAY T TEETER R G | 1992 | Nutrition Research1992，12，12： | 1 |
| 13 | The effects of estrogen depletion andisoflavones on bone metabolism in rats显示文摘 | Deyhim F Stoecker J B Brusewitz G H | 2003 | Nutrition Research2003，23，： | 1 |
| 14 | An evalua- tion of dietary riboflavin supplementation on growth rate,feed efficiency, ration metabolizable energy con- tent, and glutathione reductase activity of broilers显示文摘 | DEYHIM F BELAY T TEETER R G | 1992 | Nutr Res1992，12，9： | 1 |
| 15 | Ipriflavone modulates IGF-1 but is unable to restore bone in rats显示文摘 | DEYHIM F SMITH BJ SOUNG DY | 2005 | Phytother Res2005，19，2： | 1 |
| 16 | Sodium and potassium chloride drinking water supplementation effects on acid-base balance and plasma corticosterone in broilers reared in thermoneutral and heat-distressed environments 显示文摘 | Deyhim F | 1991 | Poultry Science1991，70，12： | 1 |
| 17 | An evaluation of dietary riboflavin supplementation on growth rate, feed efficiency, ration metabolizable energy content, and glutathione reductase activity of broilers 显示文摘 | DEYHIM F BELAY T TEETER R G | 1992 | Nu- trition Research1992，12，9： | 1 |
| 18 | Comparison of day five acclimation and fasting techniques to reduce broiler heat distress mortality 显示文摘 | McDonald K Belay T Deyhim F | 1990 | Annu-Rep-Okla-Agric-Exp-Stn1990，129，： | 1 |
| 19 | Citrus juice modulates bone strength in male senescent rat model of osteoporosis显示文摘 | Deyhim F Garica K Lopez E | 2006 | NUTRITION2006，22，5： | 1 |
| 20 | Dried plum reverses bone loss in an osteopenic rat model of osteoporosis显示文摘 | Deyhim F Stoecker BJ Brusewitz GH | 2005 | Menopause2005，12，6： | 1 |
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