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| 1 | MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells显示文摘MicroRNAs 玩在 carcinogenesis 和肿瘤的重要角色进行。肺癌症是世界范围的癌症死亡的领先的原因。在这研究, miR-181a-5p 的功能在 non-small-cell 肺癌症(NSCLC ) 被调查。结果证明 miR-181a-5p 显著地在 NSCLC 纸巾和房间线被减少。有 miR-181a-5p 的 A549 房间 transfected 的增长和迁居模仿显著地被禁止。酶活动试金结果证明 Kras 的二个有约束力的地点能被 miR-181a-5p 直接指向。而且, Kras 由在 transcriptional 和翻译层次的 miR-181a-5p 是下面调整的。调停 SiRNA 的 Kras 下面规定能模仿 miR-181a-5p 的效果在 A549 模仿房间。我们的调查结果建议 miR-181a-5p 由部分指向 Kras 在肿瘤抑制起一个潜在的作用并且在 NSCLC 病人有潜在的治疗学的申请。 | Zhongliang Ma Xiang Qiu Detao Wang Yanli Li Bingjie Zhang Tianwei Yuan Jiali Wei Botao Zhao Xintai Zhao Jiatao LOU Yan Jin Youxin Jin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 2 | Characteristics of size distributions and sources of water-soluble ions in Lhasa during monsoon and non-monsoon seasons显示文摘To understand the physical and chemical characteristics, particle size distribution and sources of size-separated aerosols in Lhasa, which is located on the Tibetan Plateau(TP), six sizes of aerosol samples were collected in Lhasa in 2014. Ca^(2+), NH_4^+, NO_3^-,SO_4^(2-)and Cl-were the dominant ions. The ratio of cation equivalents(CE) to anion equivalents(AE) for each particle size segment indicated that the atmospheric aerosols in Lhasa were alkaline. SO_4^(2-)and NO_3^-could be neutralized by Ca^(2+), but could not be neutralized by NH_4^+, according to the [NH_4^+]/[NO_3^-+ SO_4^(2-)] and [Ca^(2+)]/[NO_3^-+ SO_4^(2-)] ratios. Mobile sources were dominant in PM_(0.95-1.5),PM_(1.5-3) and PM_(3-7.2), while stationary sources were dominant in the other three size fractions according to the [NO_3^-]/[SO_4^(2-)] ratios. The particle size distribution of all watersoluble ions during monsoon and non-monsoon periods was characterized by a bimodal distribution due to the different sources and formation mechanisms, and it was revealed that different ions had different sources in different seasons and different particle size segments by combining particle size distribution with correlation analysis. Source analysis of aerosols in Lhasa was performed using the Principal component analysis(PCA) for the first time, which revealed that combustion sources, motor vehicle exhaust, photochemical reaction sources and various types of dust were the main sources of Lhasa aerosols.Furthermore, Lhasa's air quality was also affected by long-distance transmission, expressed as pollutants from South Asia and West Asia, which were transmitted to Lhasa according to backward trajectory analysis. | Nannan Wei Zhiyou Xu Junwen Liu Guanghua Wang Wei Liu Deqing Zhuoga Detao Xiao Jian Yao | 2019 | Journal of Environmental Sciences2019，31，8： | 7 |
| 3 | Interface engineering of high efficiency perovskite solar cells based on ZnO nanorods using atomic layer deposition显示文摘尽管有无机器官的金属混血儿 perovskite 太阳能电池(PSC ) 的更加改进的效率,电子运输仍然是一个挑战性的问题。在这份报纸,我们报导 ZnO nanorods 的使用准备了由热水象在 perovskite 的电子运输层自己组装太阳能电池。perovskite 太阳能电池的效率被使钝化显著地提高经由艾尔 2 ZnO nanorods 上的 O 3 单层。由采用艾尔 2 O 3 单层, methylammonium 铅碘化物 PSC 的平均力量变换效率从 10.33% ~ 15.06% 被增加,并且获得的最高的效率是 16.08% 。我们建议用单层的原子层免职的缺点的钝化可能为 PSC 的所有类型的改进提供一条新小径…… | Shibin Li Peng Zhang Yafei Wang Hojjatollah Sarvari Detao Liu Jiang Wu Yajie Yang Zhiming Wang Zhi David Chen | 2017 | Nano Research2017，10，3： | 6 |
| 4 | Flexible optoelectronic devices based on metal halide perovskites显示文摘The unique physical and chemical properties of metal halide perovskites predestine the devices to achieve high performance in optoelectronic field.Among the numerous high qualities of perovskites,their different low-temperature synthesis methods and preparation processes make them impressive and popular materials for flexible optoelectronic devices.Mainstream perovskite devices,for instance,solar cells,photodetectors and light-emitting diodes,have been fabricated on flexible substrates and show outstanding flexibility as well as high performance.For soft wearable electronic systems,mechanical flexibility is the premier condition.Compared to common devices based on rigid substrates,flexible perovskite devices are more practical and see widespread applications in energy,detection,display,and other fields.This review summarizes the recent progress of flexible perovskite solar cells,photodetectors and light-emitting diodes.The design and fabrication of different high-performance flexible perovskite devices are introduced.Various low-dimensional perovskite materials and configurations for flexible perovskite devices are presented.In addition,the limitations and challenges for further application are also briefly discussed. | Hao Chen Hao Wang Jiang Wu Feng Wang Ting Zhang Yafei Wang Detao Liu Shibin Li Richard V.Penty Ian H.White | 2020 | Nano Research2020，13，8： | 2 |
| 5 | Natural rubber/nitrile butadiene rubber/hindered phenol composites with high-damping properties显示文摘New natural rubber(NR)/nitrile butadiene rubber(NBR)/hindered phenol(AO-80)composites with high-damping properties were prepared in this study.The morpholo-gical,structural,and mechanical properties were characterized by atomic force micro-scopy(AFM),polarized Fourier transform infrared spectrometer(FTIR),dynamic mechanical thermal analyzer(DMTA),and a tensile tester.Each composite consisted of two phases:the NR phase and the NBR/AO-80 phase.There was partial compat-ibility between the NR phase and the NBR/AO-80 phase,and the NR/NBR/AO-80(50/50/20)composite exhibited a co-continuous morphology.Strain-induced crystal-lization occurred in the NR phase at strains higher than 200%,and strain-induced orientation appeared in the NBR/AO-80 phase with the increase of strain from 100%to 500%.The composites had a special stress–strain behavior and mechanical properties because of the simultaneous strain-induced orientation and strain-induced crystalliza-tion.In the working temperature range of a seismic isolation bearing,the composites(especially the NR/NBR/AO-80(50/50/20)composite)presented a high loss factor,high area of loss peak(TA),and high hysteresis energy.Therefore,the NR/NBR/AO-80 rubber composites are expected to have important application as a high-perfor-mance damping material for rubber bearing. | Xiuying Zhao Jingna Yang Detao Zhao Yonglai Lu Wencai Wang Liqun Zhang Toshio Nishi | 2015 | International Journal of Smart and Nano Materials2015，6，4： | 2 |
| 6 | Carbon-supported layered double hydroxide nanodots for efficient oxygen evolution: Active site identification and activity enhancement显示文摘In this study,we developed a novel confinement-synthesis approach to layered double hydroxide nanodots(LDH-NDs)anchored on carbon nanoparticles,which formed a three-dimensional(3D)interconnected network within a porous carbon support derived from pyrolysis of metal-organic frameworks(C-MOF).The resultant LDH-NDs@C-MOF nonprecious metal catalysts were demonstrated to exhibit super-high catalytic performance for oxygen evolution reaction(OER)with excellent operation stability and low overpotential(-230 mV)at an exchange current density of 10 mA·cm^(-2).The observed overpotential for the LDH-NDs@C-MOF is much lower than that of large-sized LDH nanosheets(321 mV),pure carbonized MOF(411 mV),and even commercial RuO_(2)(281 mV).X-ray absorption measurements and density functional theory(DFT)calculations revealed partial charge transfer from Fe^(3+)through an O bridge to Ni^(2+)at the edge of LDH-NDs supported by C-MOF to produce the optimal binding energies for OER intermediates.This,coupled with a large number of exposed active sides and efficient charge and electrolyte/reactant/product transports associated with the porous 3D C-MOF support,significantly boosted the OER performance of the LDH-ND catalyst with respect to its nanosheet counterpart.Apart from the fact that this is the first active side identification for LDH-ND OER catalysts,this work provides a general strategy to enhance activities of nanosheet catalysts by converting them into edge-rich nanodots to be supported by 3D porous carbon architectures. | Shenlong Zhao Detao Zhang Shuai Jiang Yanglansen Cui Haijing Li Juncai Dong Zhirun Xie Da-Wei Wang Rose Amal Zhenhai Xia Liming Dai | 2021 | Nano Research2021，14，9： | 1 |
| 7 | miRNAs associated with the malignant transformation of non-small cell lung cancer显示文摘肺癌症是癌症相关的死亡的领先的原因在中国并且全球,与非小的房间肺癌症(NSCLC ) 为 80% 所有肺癌症的财务。尽管有在临床的策略的改进,在药品治疗以后的 5 年的幸存率仍然是很差的[1,2 ] 。KRAS 变化被发现是显著地在腺癌病人更经常[3 ] 。p53 抄写因素是批评肿瘤 suppressor,作为由它在所有人的癌症的一半上被变异在并且 p53 0 老鼠与 100% 外显率得癌症的观察证实了[4 ] 。而且,有 p53/LKB1 损失的 KRAS 变化的存在在现出症状之前的潜的鼠科的模型授与更坏的结果并且为到 selumetinib 和 docetaxel 的抵抗是预兆的[5 ] 。到对待人 NSCLC,因此,更好的目标的鉴定基于背景遗传型成为了最大的重要性的一个立即的目标,并且为新、更有效的策略的发展关键。 | Detao Wang Qian Zhang Youxin Jin | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 0 |
| 8 | miR-290 contributes to the low abundance of cyclin D1 protein in mouse embryonic stem cells显示文摘老鼠 miR-290 簇 miRNAs 在早胚胎和胚胎的细菌房间明确地被表示。这些 miRNAs 戏在 pluripotency 和自强的维护的关键角色。这里,我们证明 Cyclin D1 是 miR-290 簇 miRNAs 的直接目标基因。在在 pluripotent 和 non-pluripotent 房间,以及在区分 CGR8 房间的 Cyclin D1 蛋白质和 miR-290 簇 miRNAs 的表示之间的否定关系被观察。miR-290 簇 miRNAs 的抑制能在 G1 阶段逮捕房间并且在 CGR8 老鼠干细胞减慢房间增长。因为 miR-290 簇 miRNAs 是最主导的 stem-cell-specific miRNAs,我们的结果在老鼠为 Cyclin D1 的缺席揭示了一个重要原因胚胎的干细胞。 | Zizhen Gong Detao Wang Shaoliang Zhu Yuqing Xia Chunsun Fan Botao Zhao Youxin Jin | 2017 | Acta Biochimica et Biophysica Sinica2017，49，7： | 0 |
| 9 | Simple and sensitive microRNA labeling by terminal deoxynucleotidyl transferase显示文摘MicroRNAs (miRNAs ) 组成非翻译的、小 RNA 的一个极其重要的类,它 post-transcriptionally 经由多重机制之一调整基因表示。到侧面 miRNA 表示, microarrays 广泛地被用于 miRNAs 的高产量的察觉。这里,我们由 terminal-deoxynucleotidyl transferase (TdT ) 为 microarray 察觉描述了一个新奇 3 结束标记 miRNA 方法。TdT 能与 deoxycytidine triphosphate (dCTP ) 在 RNA 受体分子催化多核苷酸的形成。用这项活动, miRNA 被把荧光 dCTPs 加到它的 3 结束成功地标记。这个标记的方法很简单、敏感。标记 TdT 方法几乎不能象合成小 RNA 的 0.04 fmol 一样检测,并且生产从合成小 RNA 的 0.04 ~ 5 fmol 跨越一个线性动态范围的精确、精确的大小。在我们的 TdT 方法和即时聚合酶链反应分析之间的 miRNA 表示数据的高一致性显示了 TdT 方法的可靠性和精确性。一起拿,这些结果为 miRNA 的敏感、高产量的 microarray 分析强调标记 TdT 方法的巨大的潜在的应用程序表达式。 | Botao Zhao Zhizheng Gong Zhongliang Ma Detao Wang Youxin Jin | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 0 |
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