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| 1 | Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis显示文摘During sepsis,neutrophil activation induces endothelial cell(EC)dysfunction partly through neutrophil extracellular trap(NET)release.The triggering receptor expressed on myeloid cell-1(TREM-1)is an orphan immune receptor that amplifies the inflammatory response mediated by Toll-like receptor-4(TLR4)engagement.Although the key role of TLR4 signaling in NETosis is known,the role of TREM-1 in this process has not yet been investigated.Here,we report that TREM-1 potentiates NET release by human and murine neutrophils and is a component of the NET structure.In contrast,pharmacologic inhibition or genetic ablation of TREM-1 decreased NETosis in vitro and during experimental septic shock in vivo.Moreover,isolated NETs were able to activate ECs and impair vascular reactivity,and these deleterious effects were dampened by TREM-1 inhibition.TREM-1 may,therefore,constitute a new therapeutic target to prevent NETosis and associated endothelial dysfunction. | Amir Boufenzer Kevin Carrasco Lucie Jolly Benjamin Brustolin Elisa Di-Pillo Marc Derive Sébastien Gibot | 2021 | Cellular & Molecular Immunology2021，18，2： | 9 |
| 2 | Part 2: structure/property relationships-foaming, disper- sion, and wetting显示文摘 | Piispanen P S Persson M Claesson P Surface properties of surfaetants derived from natural products | 2004 | Journal of Surfaetants and Deter- gents2004，7，2： | 1 |
| 3 | Urine sTREM-1 assessment in diagnosing sepsis and sepsis-related acute kidney injury显示文摘 | Derive M Gibot S | 2011 | Crit Care2011，15，6： | 1 |
| 4 | Triggering receptor expressed on myeloid ceils - 1 as a new therapeutic target during inflammatory diseases 显示文摘 | Derive M Massin F Gibot S | 2010 | Self Nonself2010，1，3： | 1 |
| 5 | Triggering receptor expressed on myeloid cells-1 as a new therapeutic target during inflammatory diseases显示文摘 | Derive M Massin F Gibot S | 2010 | Self Nonself2010，1，3： | 1 |
| 6 | Urine sTREM-1 assessment in diagnosing sepsis and sepsis-related acute kidney injury 显示文摘 | Derive M Gibot S | 2011 | Crit Care2011，15，6： | 1 |
| 7 | Experimen- evaluation of anti-tumor Vinca rosea Linn 显示文摘 | Johnson I S Wright H F tal basis for clinical principles derived from Svoboda G H | 1959 | J Lab Clin Med1959，54，5： | 1 |
| 8 | Renocortical mRNA expression of vasoactive factors during spironolactone protective effect in chronic cyclosporine nephrotoxicity显示文摘 | Pérez-Rojas JM Derive S Blanco JA | 2005 | Am J Physiol Renal Physiol2005，289，5： | 1 |
| 9 | trin显示文摘 | Schmidt A Cottaz S Driguez H Schulz G Structure of cyclodextrin glycosyhransferase complexed with a derivative of its main product f3-cyclodex | 1998 | Biochern1998，37，： | 1 |
| 10 | Natural foods modulate nitric oxide production and oxidative status in epithelial lung cells 显示文摘 | Zaslaver M Offer S compounds derived from Kerem Z | 2005 | J Agric Food Chem2005，53，26： | 1 |
| 11 | Preparation of α - Hydroxy and ot - Alkoxy Esters 显示文摘 | Aller E Brown D S Cox G G Diastereoselectivity in the O - H insertion reactions of rhodium carbenoids derived from phenyldiazoacetates of chiral alcohols | 1995 | J Org Chem1995，60，： | 1 |
| 12 | aureus expressed on two different plant viruses 显示文摘 | Brennan F R Jones T D Longstaff M Immunoge nicity of peptides derived from a fibronectin bindingprotein of S | 1999 | Vaccine1999，17，1516： | 1 |
| 13 | Triggering receptor expressed on myeloid cells-1 as a new therapeutic target during inflammatory diseases 显示文摘 | Derive M Massin F Gibot S | 2010 | Self Nonself2010，1，3： | 1 |
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