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| 1 | Tumour suppressor PTEN enhanced enzyme activity of GPx, SOD and catalase by suppression of PI3K/AKT pathway in non-small cell lung cancer cell lines 显示文摘 | Akca H Demiray A Aslan M | 2013 | J Enzyme Inhib Med Chem2013，28，3： | 1 |
| 2 | Invasiveness and anchorage independent growth ability augmented by PTEN inactivation through the PI3K/AKT/NFkB pathway in hmg cancer cells 显示文摘 | Akca H Demiray A Tokgun O | 2011 | Lung Cancer2011，73，3： | 1 |
| 3 | Utility of serum DNA and pyrosequencing for the detection of EGFR mutations in non-small cell lung cancer显示文摘 | Akca H Demiray A Yaren A | 2013 | Cancer Genet2013，206，3： | 1 |
| 4 | Stabilization of large power systems using VSC-HVDC and model predictive control显示文摘 | Fuchs A Imhof M Demiray T | 2014 | IEEE Transactions on Power Delivery2014，29，1： | 1 |
| 5 | Comparison of adenoid and tonsil core cultures in chronic adenotonsillitis 显示文摘 | Kocatiirk S Demiray T Incesulu A | 2003 | Kulak Burun Bogaz Ihtis Derg2003，10，3： | 1 |
| 6 | Utility of serum DNA and pyrosequencing for the detection of EGFR mutations in non-small cell lung cancer显示文摘 | Akca H Demiray A Yaren A | 2013 | Cancer Genet2013，206，3： | 1 |
| 7 | Invasiveness and anchor- age independent growth ability augmented by PTEN inaclivation through the PI3K/AKT/NFkB pathway in lung cancer cells显示文摘 | Akca H Demiray A Tokgun O | 2011 | Lung Cancer2011，73，3： | 1 |
| 8 | Comparison of adenoid and tonsil core cultures in chronic adenotonsillitis显示文摘 | Kocaturk S Demiray T Incesulu A | 2003 | Kulak Burun Bogaz Ihtis Derg2003，10，3： | 1 |
| 9 | Invasiveness and an- chorage independent growth ability augmented by PTEN inactivation through the PI3K/AKT/NFkB pathway in lung cancer cells显示文摘 | Akca H Demiray A Tokgun O | 2011 | Lung Cancer2011，73，3： | 1 |
| 10 | Stabilization of large power systems using VSC-HVDC and model predictive control显示文摘 | Fuchs A Imhof M Demiray T | 2014 | IEEE Transactions on Power Delivery2014，29，1： | 1 |
| 11 | Chemical composition and antibacterial properties of stem and leaf extracts from Ginja cherry plant显示文摘 | Piccirillo C Demiray S Silva-Ferreira A C | 2013 | Industrial Crops and Products2013，，43： | 1 |
| 12 | Differential effects of nitrogen and sulfur deprivation on growth and biodiesel feedstock production of Chlamydomonas reinhardtii 显示文摘 | Cakmak T Angun P Demiray Y E Ozkan A D Elibol Z Tekinay T | 2012 | Biotechnology and Bioengineering2012，109，8： | 1 |
| 13 | Utility of serum DNA and pyrosequencing for the detection of EGFR mutations in non- small cell lung cancer显示文摘 | Akca H Demiray A Yaren A | 2013 | Cancer Genet2013，206，3： | 1 |
| 14 | Protective effect of insulin and glucose at different concentrations on penicillin-induced astrocyte death on the primer astroglial cell line显示文摘Astrocytes perform many functions in the brain and spinal cord.Glucose metabolism is important for astroglial cells and astrocytes are the only cells with insulin receptors in the brain.The common antibiotic penicillin is also a chemical agent that causes degenerative effect on neuronal cell.The aim of this study is to show the effect of insulin and glucose at different concentrations on the astrocyte death induced by penicillin on primer astroglial cell line.It is well known that intracranial penicillin treatment causes neuronal cell death and it is used for experimental epilepsy model commonly.Previous studies showed that insulin and glucose might protect neuronal cell in case of proper concentrations.But,the present study is about the effect of insulin and glucose against astrocyte death induced by penicillin.For this purpose,newborn rat brain was extracted and then mechanically dissociated to astroglial cell suspension and finally grown in culture medium.Clutters were maintained for 2 weeks prior to being used in these experiments.Different concentrations of insulin(0,1,3 nM)and glucose(0,3,30 mM)were used in media without penicillin and with 2 500μM penicillin.Penicillin decreased the viability of astroglial cell seriously.The highest cell viability appeared in medium with 3 nM insulin and 3 mM glucose but without penicillin.However,in medium with penicillin,the best cell survival was in medium with 1 nM insulin but without glucose. We concluded that insulin and glucose show protective effects on the damage induced by penicillin to primer astroglial cell line.Interestingly,cell survival depends on concentrations of insulin and glucose strongly.The results of this study will help to explain cerebrovascular pathologies parallel to insulin and glucose conditions of patient after intracranial injuries. | Mehmet Bülent zdemir Hakan Aka agdas Erdogan Onur Tokgün Aydin Demiray Fenki Semin Cem Becerir | 2012 | Neural Regeneration Research2012，7，24： | 0 |
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