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| 1 | From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world显示文摘Hepatocellular carcinoma(HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma. | Dimitrios Dimitroulis Christos Damaskos Serena Valsami Spyridon Davakis Nikolaos Garmpis Eleftherios Spartalis Antonios Athanasiou Demetrios Moris Stratigoula Sakellariou Stylianos Kykalos Gerasimos Tsourouflis Anna Garmpi Ioanna Delladetsima Konstantinos Kontzoglou Gregory Kouraklis | 2017 | World Journal of Gastroenterology2017，23，29： | 44 |
| 2 | Mucins in neoplasms of pancreas,ampulla of Vater and biliary system显示文摘Tumors of the pancreas,the ampulla of Vater,and the extrahepatic and intrahepatic bile ducts have significant histological similarities due to the common embryonic origin of the pancreatobiliary system.This obviates the need for discovery of biomarkers with diagnostic and prognostic value for these tumors.Mucins,especially MUC-1,-2,-4 and-5AC,are important candidates for developing into such reliable biomarkers.Increased expression of MUC1 occurs in pancreatic ductal adenocarcinomas and is associated with increased degrees of dysplasia in pancreatic intraepithelial neoplasia(Pan IN).Positive expression of MUC2 in intraductal papillary mucinus neoplasms(IPMN) of the intestinal type indicates high potential progression to invasive carcinoma with de novo expression of MUC1,while absence of MUC2 expression in IPMNs of gastric type implies low potential to malignant evolution.De novo MUC4 expression correlates to the severity of dysplasia in Pan IN and is associated with a poor prognosis in patients with pancreatic ductal adenocarcinomas.In biliary intraepithelial neoplasia(Bil IN),increased expression of MUC1 is associated with higher degrees of dysplasia.Intrahepatic cholangiocarcinomas(ICC) are characterized by increased expression of all glycoforms of MUC1.Positive MUC2 expression in intraductal papillary neoplasm of the bile ducts(IPNB) of the intestinal type indicates high malignant potential with de novo expression of MUC1 in the invasive element.Absent MUC2 expression in any degree of Bil IN may prove useful in differentiating them from IPNB.De novo expression of MUC4 is associated with poor prognosis in patients with ICC or carcinoma of the extrahepatic bile ducts(EHBDC).High de novo expression of MUC5 AC is found in all degrees of Bil IN and all types of IPNB and ICC.The MUC5 AC is useful in the detection of neoplastic lesions of the bile duct at an early stage.Increased expression of mucin MUC1 in carcinoma of the ampulla of Vater associated with unfavorable behavior of the tumor,such as lymph node metastasis,infiltration of the pancreas and duodenum,advanced TNM classification and worse prognosis.Patients withintra-ampullary papillary-tubular neoplasm(IAPN) of the pancreatobiliary immunophenotype did not show MUC2,while those of the intestinal immunophenotype are MUC2 positive.The expression of MUC4 is associated with poor prognosis in patients with carcinoma of the ampulla of Vater favoring metastasis and making them resistant to apoptosis.Moreover,it appears that MUC4 positivity correlates with recurrence of the tumor.Expression of MUC5 AC is associated with the invasive potential of the tumor. | Dimitrios Moschovis Giorgos Bamias Ioanna Delladetsima | 2016 | World Journal of Gastrointestinal Oncology2016，8，10： | 4 |
| 3 | Hepatitis C in hemodialysis patients显示文摘Despite reduction of hepatitis C prevalence after recognition of the virus and testing of blood products, hemodialysis(HD) patients still comprise a high risk group. The natural history of hepatitis C virus(HCV) infection in dialysis is not fully understood while the clinical outcome differs from that of the general population. HD patients show a milder liver disease with lower aminotransferase and viral levels depicted bymilder histological features on liver biopsy. Furthermore, the 'silent' clinical course is consistent with a slower disease progression and a lower frequency of cirrhosis and hepatocellular carcinoma. Potential explanations for the 'beneficial' impact of uremia and hemodialysis on chronic HCV infection are impaired immunosurveillance leading to a less aggressive host response to the virus and intradialytic release of 'hepatoprotective' cytokines such as interferon(IFN)-α and hepatocyte growth factor. However, chronic hepatitis C is associated with a higher liver disease related cardiovascular and allcause mortality of HD patients. Therapy is indicated in selected patients groups including younger patients with low comorbidity burden and especially renal transplant candidates, preferably after performance of a liver biopsy. According to current recommendations, choice of treatment is IFN or pegylated interferon with a reported sustained viral response at 30%-40% and a withdrawal rate ranging from 17% to 30%. New data regarding combination therapy with low doses of ribavirin which provide higher standard variable rates and good safety results, offer another therapeutic option. The new protease inhibitors may be the future for HCV infected HD patients, though data are still lacking. | Smaragdi Marinaki John N Boletis Stratigoula Sakellariou Ioanna K Delladetsima | 2015 | World Journal of Hepatology2015，7，3： | 2 |
| 4 | The liver in bmce- llosis显示文摘 | Akritidis N Tzivras M Delladetsima I | 2007 | Clin Gastroenterol Hepatol2007，5，9： | 1 |
| 5 | The liver in Brucellosis 显示文摘 | Akritidis N Tzivras M Delladetsima I Stefanaki S Moutsopoulos HM Pappas G | 2007 | Clin Gastroenterol Heptol2007，4，： | 1 |
| 6 | Differential diagnosis of acute HBsAg positive hepatitis using IgM anti-HBc by a rapid, fully automated microparticle enzyme immunoassay显示文摘 | Nicolaos C. Tassopoulos George V. Papaptheodoridis Yiannis Kalantzakis Evangelia Tzala Johanna K. Delladetsima Maria G. Koutelou Paraskevi Angelopoulou Angelos Hatzakis | 1997 | Journal of Hepatology1997，，1： | 1 |
| 7 | The liver in brucellosis显示文摘 | Akritidis N M Tzivras I Delladetsima | 2007 | Clin Gastroenterol Hepatol2007，5，9： | 1 |
| 8 | The liver in brucellosis显示文摘 | Akritidis N Tzivras M Delladetsima I | 2007 | Clin Gastroenterol Hepatol2007，5，9： | 1 |
| 9 | Fulminant hepatitis due to Epstein-Barr virus infection显示文摘 | Papatheodoridis GV Delladetsima JK Kavallierou L | 1995 | J Hepatol1995，23，3： | 1 |
| 10 | Liver biopsy is essential in anti - HCV renal transplant pationts irrespective of liver function tests and serology for HCV显示文摘 | Delladetsima J Psimonou E | 1995 | Transplant Proc1995，27，： | 1 |
| 11 | Hepatocellular carcinoma present ing with paraneoplastic neurologic syndrome i n a hepatitis B surface antigen-positive patient显示文摘 | Delladetsima I koufos C | 1998 | J Clin Gastroenterol1998，26，2： | 1 |
| 12 | The liver in brucellosis 显示文摘 | Akritidis N Tzivras M Delladetsima I | 2007 | Clin Gastroenterol Hepatol2007，5，9： | 1 |
| 13 | Hepatoid adenocarcinoma of the stomach with extensive neuroendocrine differentiation and a coexisting carcinoid tumour显示文摘 | Rassidakis GZ Delladetsima JK Letsos SP | 1998 | Histopathology1998，33，2： | 1 |
| 14 | Fibrosing cholestatic hepatitis in renal transplant recipients with hepatitis C virus infection显示文摘 | Delladetsima JK Boletis JN Makris F | 1999 | Liver Transpl Surg1999，5，4： | 1 |
| 15 | Significance of immune status, genotype and viral load in the severity of chronic hepatitis C in HIV infected haemophilia patients 显示文摘 | Delladetsima J Katsarou O Touloumi G | 2002 | Haemophilia2002，8，5： | 1 |
| 16 | Cholestatic syndromes in renal transplant recipients with HCV infection显示文摘 | Boletis JN Delladetsima JK Makris F | 2000 | Transpl Int2000，13，1： | 1 |
| 17 | The liver in brucellosis 显示文摘 | Akritidis N Tzivras M Delladetsima I | 2007 | Clin Gastroenterol Hepatol2007，5，9： | 1 |
| 18 | Hepatoid Adenocarcinoma of the Gallbladder显示文摘 | H. Gakiopoulou N. Givalos G. Liapis G. Agrogiannis E. Patsouris I. Delladetsima | 2007 | Digestive Diseases and Sciences2007，，12： | 1 |
| 19 | Early ileocolonoscopy with biopsy for the evaluation of persistent post-transplantation diarrhea显示文摘AIM: To investigate the signifi cance of ileocolonoscopy with histology in the evaluation of post-transplantation persistent diarrhea (PD). METHODS: We retrospectively reviewed all records of renal transplant patients with PD, over a 3-year period. All patients were referred for ileocolonoscopy with biopsy, following a negative initial diagnostic work up. Clinical and epidemiological data were compared between cases with infectious or drug-induced diarrhea. RESULTS: We identif ied 30 episodes of PD in 23 renaltransplant patients (1-3 cases per patient). There were 16 male patients and the mean age at the time of PD was 51.4 years. The average time from transplantation to a PD episode was 62.3 ± 53.2 mo (range 1-199 mo). Ileocolonoscopy detected mucosal abnormalities in 19 cases, whereas the intestinal mucosa appeared normal in 11 cases. Histological examination achieved a specific diagnosis in 19/30 cases (63.3%). In nine out of 11 cases (82%) with normal endoscopic appearance of the mucosa, histological examination of blinded biopsies provided a specif ic diagnosis. The etiology of PD was infectious in 11 cases (36.6%), drug-related in 10 (33.3%), of other causes in three (10%), and of unknown origin in six cases (20%). Infectious diarrhea occurred in significantly longer intervals from transplantation compared to drug-related PD (85.5 ± 47.6 mo vs 40.5 ± 44.8 mo, P < 0.05). Accordingly, PD due to drug-toxicity was rarely seen after the f irst year post-transplantation. Clinical improvement followed therapeutic intervention in 90% of cases. Modif ication of immunosuppressive regimen was avoided in 57% of patients. CONCLUSION: Early ileocolonoscopy with biopsies from both affected and normal mucosa is an important adjunctive tool for the etiological diagnosis of PD in renal transplant patients. | Giorgos Bamias John Boletis Theodoros Argyropoulos Chrysanthi Skalioti Spyros I Siakavellas Ioanna Delladetsima Irene Zouboulis-Vafiadis George L Daikos Spiros D Ladas | 2010 | World Journal of Gastroenterology2010，16，30： | 1 |
| 20 | The liver in brucello- sis显示文摘 | Akritidis N Tzivras M Delladetsima I | 2007 | Clin Gastroenterol Hepatol2007，5，9： | 1 |
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