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| 1 | DNA image cytometry test for primary screening of esophageal cancer: a population-based multi-center study in high-risk areas in China显示文摘Objective: To evaluate the feasibility of DNA image cytometry(DNA-ICM) as a primary screening method for esophageal squamous cell cancer(ESCC).Methods: A total of 5,382 local residents aged 40–69 years from three high-risk areas in China(Linzhou in Henan province, Feicheng in Shandong province and Cixian in Hebei province) from 2008 to 2011 were recruited in this population-based screening study. And 2,526 subjects declined to receive endoscopic biopsy examination with Lugol's iodine staining, while 9 and 815 subjects were excluded from liquid-based cytology and DNA-ICM test respectively due to slide quality. Finally, 2,856, 5,373 and 4,567 subjects were enrolled in the analysis for endoscopic biopsy examination, liquid-based cytology and DNA-ICM test, respectively. Sensitivity(SE), specificity(SP), negative predictive values(NPV) and positive predictive values(PPV) as well as their 95% confidence intervals(95% CI) for DNA-ICM, liquid-based cytology and the combination of the two methods were calculated. Receiver operating characteristic(ROC) curves were applied to determine the cutoff point of DNA-ICM for esophageal cancer.Results: DNA-ICM results were significantly correlative with esophageal cancer and precancer lesions(χ~2=18.016, P<0.001). The cutoff points were 5,802, 5,803 and 8,002 based on dissimilar pathological types of low grade intraepithelial neoplasia(LGIN), high grade intraepithelial neoplasia(HGIN), and ESCC, respectively, and 5,803 was chosen in this study considering the SE and SP. The SE, SP, PPV, NPV of DNA-ICM test(cutoff point 5,803) combined with liquid-based cytology [threshold atypical squamous cells of undetermined significance(ASCUS)] were separately 72.1%(95% CI: 70.3%-73.9%), 43.3%(95% CI: 41.3%-45.3%), 22.8%(95% CI: 21.1%-24.5%) and 87.0%(95% CI: 85.7%-88.3%) for LGIN, 85.7%(95% CI: 84.3%-87.1%), 41.3%(95% CI: 39.3%-43.3%), 4.6%(95% CI: 3.8%-5.4%) and 98.9%(95% CI: 98.5%-99.3%) for HGIN, and 96.0%(95% CI: 95.2%-96.8%), 40.8%(95% CI: 38.8%-42.8%), 1.7%(95% CI: 1.2%-2.2%) and 99.9%(95% CI: 99.8%-100.0%) for ESCC.Conclusions: It is possible to use DNA-ICM test as a primary screening method before endoscopic screening for esophageal cancer. | Meng Wang Changqing Hao Qing Ma Guohui Song Shanrui Ma Deli Zhao Lin Zhao Xinqing Li Wenqiang Wei | 2016 | Chinese Journal of Cancer Research2016，28，4： | 15 |
| 2 | Clinical practices s of Traditional Chinese Medicine for acute upper respiratory tract infection in children显示文摘OBJECTIVE:To develop Clinical practice s of Traditional Chinese Medicine(TCM) for acute upper respiratory tract infection(AURI) in children;TCM is usedalone or administered together with antibiotics.METHODS:Under the guidance of evidence-based medicine concept,in strict accordance with the rules of international s development,as well as on the basis of evidence of clinical research of TCM,the s solicited opinions from clinical experts and methodologists in TCM and Western Medicine.GRADE standard was applied to form experts' consensus.RESULTS:The s standardized classification of TCM patterns and TCM treatments in children with AURI,including prescription,Chinese patent medicine,non-drug treatment and prevention.CONCLUSION:Follows the principle of 'evidence based,consensus supplemented,and experience referred',these s were formulated,but the quality of evidence of included studies were relatively low.Further refinement of the s should be needed as deeper clinical studies as available in future. | Rong Ping Li Li Zhang Xilian Liu Quanhui Yan Huimin Xin Deli Xue Zheng Ren Xianqing Wu Zhenqi Ma Rong Zhang Junhua | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 7 |
| 3 | Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells显示文摘Our previous studies found that mitochondrial uncouplers CCCP and niclosamide inhibited artery constriction and the mechanism involved AMPK activation in vascular smooth muscle cells. BAM15 is a novel type of mitochondrial uncoupler. The aim of the present study is to identify the vasoactivity of BAM15 and characterize the BAM15-induced AMPK activation in vascular smooth muscle cells(A10 cells). BAM15 relaxed phenylephrine(PE)-induced constricted rat mesenteric arteries with intact and denuded endothelium. Pretreatment with BAM15 inhibited PEinduced constriction of rat mesenteric arteries with intact and denuded endothelium. BAM15, CCCP,and niclosamide had the comparable IC50 value of vasorelaxation in PE-induced constriction of rat mesenteric arteries. BAM15 was less cytotoxic in A10 cells compared with CCCP and niclosamide.BAM15 depolarized mitochondrial membrane potential, induced mitochondrial fission, increased mitochondrial ROS production, and increased mitochondrial oxygen consumption rate in A10 cells.BAM15 potently activated AMPK in A10 cells and the efficacy of BAM15 was stronger than that of CCCP, niclosamide, and AMPK positive activators metformin and AICAR. In conclusion, BAM15 activates AMPK in vascular smooth muscle cells with higher potency than that of CCCP, niclosamide and the known AMPK activators metformin and AICAR. The present work indicates that BAM15 is a potent AMPK activator. | Yu Tai Lanjun Li Xuan Peng Junxue Zhu Xihai Mao Nan Qin Minghui Ma Rong Huo Yunlong Bai Deli Dong | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 4 | EQUIVALENT NORMAL CURVATURE APPROACH MILLING MODEL OF MACHINING FREEFORM SURFACES显示文摘A new milling methodology with the equivalent normal curvature milling model machining freeform surfaces is proposed based on the normal curvature theorems on differential geometry. Moreover,a specialized whirlwind milling tool and a 5-axis CNC horizontal milling machine are introduced.This new milling model can efficiently enlarge the material removal volume at the tip of the whirlwind milling tool and improve the producing capacity.The machining strategy of this model is to regulate the orientation of the whirlwind milling tool relatively to the principal directions of the workpiece surface at the point of contact,so as to create a full match with collision avoidance between the workpiece surface and the symmetric rotational surface of the milling tool.The practical results show that this new milling model is an effective method in machining complex three- dimensional surfaces.This model has a good improvement on finishing machining time and scallop height in machining the freeform surfaces over other milling processes.Some actual examples for manufacturing the freeform surfaces with this new model are given. | YI Xianzhong MA Weiguo QIHaiying YAN Zesheng GAO Deli | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 5 |
| 5 | Approaches to High-grade Sintered Magnesia from Natural Magnesite显示文摘It is hard to manufacture high purity,dense sintered-magnesia from natural magnesite in the prevailing process of calcining and sintering,for two reasons:a)impurity,and b)low sintering activity of coarse-grained magnesite.In this paper,95%MgO magnesite was used as the starting material and finally magnesia of high density(3.47 g/cm^3)and high purity(98%MgO)was obtained after the flotation purification and a three-step sintering process.An industrial scale of the beneficiation system of natural magnesite was introduced for magnesite purification.In lab experimental,the three-step sintering process was implemented by calcining,hydrating,re-calcining and sintering,which has proven the possibility of densified magnesia from natural magnesite. | GUO Zongqi BI Deli MA Ying SUN Zhenlin | 2020 | China's Refractories2020，29，3： | 3 |
| 6 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 7 | A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes显示文摘 | Nakagawa S Deli MA Kawaguchi H | 2008 | Neurochem Int2008，54，34： | 1 |
| 8 | Cloning and sequencing of matured fragment of human NGF gene 显示文摘 | Ma Wei Wu Ling Wang Deli | 2003 | Acad J XJTU2003，15，1： | 1 |
| 9 | A new blood-brain barrier mOdel using primary rat brain endothelial cells, pericytes and astrocytes 显示文摘 | Nakagawa S Deli MA Kawaguchi H | 2009 | Neurochem Int2009，54，34： | 1 |
| 10 | Cloning and sequencing of matured fragment of human NGF gene显示文摘 | Ma Wei Wu Ling Wang Deli | 2003 | Acad J X JTU2003，15，1： | 1 |
| 11 | Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmaeology显示文摘 | Deli MA Abraham CS Kataoka Y | 2005 | Cell Mol Neurobiol2005，25，： | 1 |
| 12 | Chronic adrenomedullin treatment improves blood-brain barrier function but has no effects on expression of tight junction proteins显示文摘 | Kis B Snipes JA Deli MA Abraham CS Yamashita H Ueta Y | 2003 | Acta Neurochir Suppl2003，86，： | 1 |
| 13 | Intracellulartransport of Toxoplasma gondii throu^i the blood-brain barrier显示文摘 | Lachenmaier SM Deli MA Meissner M | 2011 | J Neuroimmunol2011，232，12： | 1 |
| 14 | Adrenomedullin, an autocrine mediator of blood -brain barrier functions 显示文摘 | Kis B Abraham CS Deli MA | 2003 | Hyperten Res2003，，： | 1 |
| 15 | A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes显示文摘 | Nakagawa S Deli MA Kawaguchi H | 2009 | Neurochem Int2009，54，34： | 1 |
| 16 | A new blood-brain barrier model using primary rat brain endothelial ceils, pericytes and astrocytes 显示文摘 | NAKAGAWA S DELI MA KAWAGUCHI H | 2009 | Neurochem lnt2009，54，34： | 1 |
| 17 | Histamine induces selective albumin permeation through the blood brain barrier in vitro 显示文摘 | Deli MA Dehouck MP Cecchelli R | 1995 | Inflamm Res Suppl1995，44，1： | 1 |
| 18 | Response inhibition and set shifting in patients with frontal lobe epilepsy or temporal lobe epilepsy显示文摘 | McDonald CR Delis DC Norman MA | 2005 | Epilepsy Behav2005，7，3： | 1 |
| 19 | Pericytes from brain microvessels strengthen the barrier integrity in primary culture of rat brain endothelial cells显示文摘 | Nakagawa S Deli MA Nakao S | 2007 | Cell Mol Neurobiol2007，，6： | 1 |
| 20 | A new blood- brain barrier model using primary rat brain endothelial eells,perieytes and astroeytes显示文摘 | Nakagawa S Deli MA Kawaguehi H | 2009 | Neuroehem Int2009，54，34： | 1 |
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