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| 1 | 左氧氟沙星、加替沙星及莫西沙星对肺结核患者的早期及延长早期杀菌活性显示文摘目的:评估左氧氟沙星、加替沙星及莫西沙星等新氟喹诺酮类药物对肺结核患者的早期杀菌活性及延长早期杀菌活性。设计:随机开放临床试验。40例成年新诊断的涂阳肺结核患者(每组10例)分别每日单一接受异烟肼300mg,或左氧氟沙星1000mg,或加替沙星400mg,或莫西沙星400mg的7天治疗。治疗前2天及单药治疗7天期间,每日收集痰液进行定量培养。计量单药治疗开始的头2天(0-2天)及治疗后5天(2-7天)的菌量下降情况,以评估各药的早期及延长早期杀菌活性。对实验室工作人员关于病人治疗分组信息采用单盲法。结果:异烟肼的早期杀菌活性为0.67log10cfu/毫升/天,高于莫西沙星(0.33log10cfu/毫升/天)及加替沙星(0.35log10cfu/毫升/天)。与每日1000mg左氧氟沙星的早期杀菌活性(0.45log10cfu/毫升/天)相比,无统计学差异(P=0.14)。3种氟喹诺酮类药物的早期杀菌活性(0-2天)与延长早期杀菌活性(2-7天)相似。总体说来,氟喹诺酮类药物的延长早期杀菌活性高于异烟肼。结论:莫西沙星、加替沙星及高剂量左氧氟沙星,虽然略低于异烟肼,但均有良好的早期杀菌活性,并具有较高的延长早期杀菌活性。有理由对这些药物敏感的结核病人进行进一步的治疗研究。 | J. L. Johnson D. J. Hadad W. H. Boom C. L. Daley C. A. Peloquin K. D. Eisenach D. D. Jankus S. M. Debanne E. D. Charlebois E. Maciel M. Palaci R. Dietzet 马玙(译) 屠德华(校) 张立兴(审) | 2006 | 国际结核病与肺部疾病杂志2006，1，2： | 5 |
| 2 | Improved yields of the extracellular domain of the epidermal growth factor receptor produced using the baculovirus expression system by medium replacement following infection 显示文摘 | Tom RL Debanne MT Bedard C | 1995 | Appl Microbiol Biotechnol1995，44，12： | 1 |
| 3 | Mood and blood pressure responses in black female care givers显示文摘 | Picot ST Zansniewcki JA Debanne SM | 1999 | J Nurs Res1999，48，： | 1 |
| 4 | Angiotensin- receptor blockade and risk of cancer: meta-analysis of randomised controlled trials显示文摘 | SIPAHI I DEBANNE S M ROWLAND D Y | 2010 | Lancet Oncol2010，11，7： | 1 |
| 5 | Angiotensin-receptor blockade and risk of cancer:meta-analysis of randomized controlled trials显示文摘 | Sipahi I Debanne SM Rowland DY | | 0，，： | 1 |
| 6 | Rosuvastatin treatment reduces markers of monocyte activation in HIV-infected subjects on antiretroviral therapy 显示文摘 | Funderburq NT Jiang Y Debanne SM | 2014 | Clin Infect Dis2014，58，4： | 1 |
| 7 | Rosuvastatin reduces vascular inflammation and T-cell and monocyte activation in HIV-in- fected subjects on antiretroviral therapy显示文摘 | Funderburg NT Jiang Y Debanne SM | 2015 | J Acquir Immune Defic Syndr2015，68，4： | 1 |
| 8 | Association of Alzheimer's disease and smoking:the case for sibling controls显示文摘 | Debanne SM Rowland DY Riedel TM | 2000 | J Am Geriatr Soc2000，48，7： | 1 |
| 9 | The serodiagnosis of tuberculosis and other mycobacterial diseases by enzyme-linked immunosorbent assay显示文摘 | Daniel T M Debanne S M | 1987 | Am Rev Respir Dis1987，135，： | 1 |
| 10 | Pairedpulse facilitation and depression at unitary synapses in rat hippocampus: quantal fluctuation affects subsequent release显示文摘 | Debanne D Guerineau N C Gahwiler B H | 1996 | J Physiol1996，491，1： | 1 |
| 11 | Immunological and endocrine,conditions in an Alzheimer's disease casecontrol study显示文摘 | Lerner A Cole R Debanne S | 1995 | Neuroepidemiology1995，14，4： | 1 |
| 12 | Organotypic slice cultures: a technique has come of age 显示文摘 | Gahwiler BH Capogna M Debanne D | 1997 | Trends Neurosci1997，20，10： | 1 |
| 13 | Association of Alzheimer's disease and smoking: the case for sibling controls显示文摘 | Debanne SM Rowland DY Riedel TM | 2000 | J Am Geriatr Soc2000，48，7： | 1 |
| 14 | Elimination of asialofetuin and asialoomsomucoid by the intact rat quantitative aspects of the hepatic clearance mechanism显示文摘 | Regoeczi E Debanne MT Hatton MWC | 1978 | Biocim Biophys Acta1978，541，： | 1 |
| 15 | Interactions of apoli- poprotein E genotype and dietary fat intake of healthy older persons during mid-adult life 显示文摘 | Petot G J Traore F Debanne S M | 2003 | Metabolism2003，52，3： | 1 |
| 16 | Smoking and oestrogen- replacement therapy as protective factors for Alzheimer's disease 显示文摘 | Lerner A Koss E Debanne S | 1997 | Lancet1997，349，9049： | 1 |
| 17 | Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials显示文摘 | Sipahi I Debanne SM Rowland DY | 2010 | Lancet Oncol2010，11，7： | 1 |
| 18 | Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials显示文摘 | Sipahi I Debanne SM Rowland DY | 2010 | Lancet Oncol2010，11，7： | 1 |
| 19 | Effect of nicotine replace- ment therapy on agitation in smokers with schizophrenia: a double- blind, randomized, placebo-controlled study显示文摘 | Allen MH Debanne M Lazignac C | 2011 | American Journal of Psychiatry2011，168，4： | 1 |
| 20 | The serodiagnosis of tuberculosis and other mycobacterial diseases by enzyme-linked immunosorbent assay 显示文摘 | Daniel TM Debanne SM | 1987 | Am Rev Respir Dis1987，135，5： | 1 |
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