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| 1 | 新型可遗传编码的荧光探针实现在果蝇、斑马鱼和小鼠中快速特异地示踪多巴胺显示文摘文章简介多巴胺是神经系统中一种重要的单胺类神经递质,它介导了一系列重要的生理、病理过程。如何在自由活动的动物脑中特异、精准地示踪特定时间、区域的多巴胺释放是长期以来困扰神经科学家的技术难题。 | 孙芳妙 曾健智 井淼 Jingheng Zhou 冯杰思 Scott F.Owen 骆奕辰 Funing Li 王欢 Takashi Yamaguchi 雍自昊 Yijing Gao Wanling Peng Lizhao Wang Siyu Zhang Jiulin Du Dayu Lin Min Xu Anatol C.Kreitzer Guohong Cui 李毓龙 | 2019 | 科学新闻2019，0，2： | 1 |
| 2 | 可遗传编码的荧光探针用于在体快速特异地检测去甲肾上腺素显示文摘文章简介在人的神经系统中有数十亿个神经元,这些细胞主要通过神经递质的释放和感知完成相互之间的通讯。去甲肾上腺素(Norepinephrine,NE)是一种单胺类的神经递质,它作用于多种肾上腺素受体。在中枢神经系统和交感神经系统中都参与诸多必要的生理过程,如感觉信号的调节、注意力的调控、清醒与睡眠、学习与记忆等。 | 冯杰思 Changmei Zhang Julieta E.Lischinsky Miao Jing Jingheng Zhou Huan Wang Yajun Zhang Ao Dong Zhaofa Wu Hao Wu Weiyu Chen Peng Zhang Jing Zou S.Andrew Hires J.Julius Zhu Guohong Cui Dayu Lin Jiulin Du 李毓龙 | 2020 | 科学新闻2020，，2： | 0 |
| 3 | Phenome-wide association study and precision medicine of cardiovascular diseases in the post-COVID-19 era显示文摘SARS-CoV-2 infection causes injuries of not only the lungs but also the heart and endothelial cells in vasculature of multiple organs,and induces systemic inflammation and immune over-reactions,which makes COVID-19 a disease phenome that simultaneously affects multiple systems.Cardiovascular diseases(CVD)are intrinsic risk and causative factors for severe COVID-19 comorbidities and death.The wide-spread infection and reinfection of SARS-CoV-2 variants and the long-COVID may become a new common threat to human health and propose unprecedented impact on the risk factors,pathophysiology,and pharmacology of many diseases including CVD for a long time.COVID-19 has highlighted the urgent demand for precision medicine which needs new knowledge network to innovate disease taxonomy for more precise diagnosis,therapy,and prevention of disease.A deeper understanding of CVD in the setting of COVID-19 phenome requires a paradigm shift from the current phenotypic study that focuses on the virus or individual symptoms to phenomics of COVID-19 that addresses the inter-connectedness of clinical phenotypes,i.e.,clinical phenome.Here,we summarize the CVD manifestations in the full clinical spectrum of COVID-19,and the phenome-wide association study of CVD interrelated to COVID-19.We discuss the underlying biology for CVD in the COVID-19 phenome and the concept of precision medicine with new phenomic taxonomy that addresses the overall pathophysiological responses of the body to the SARS-CoV-2 infection.We also briefly discuss the unique taxonomy of disease as Zheng-hou patterns in traditional Chinese medicine,and their potential implications in precision medicine of CVD in the post-COVID-19 era. | Qian Cao Xin Du Xiao-yan Jiang Yuan Tian Chen-hao Gao Zi-yu Liu Ting Xu Xing-xing Tao Ming Lei Xiao-qiang Wang Lingyu Linda Ye Dayue Darrel Duan | 2023 | Acta Pharmacologica Sinica2023，44，12： | 0 |
| 4 | Attention emotion recognition via ECG signals显示文摘Background:Physiological signal-based research has been a hot topic in affective computing.Previous works mainly focus on some strong,short-lived emotions(e.g.,joy,anger),while the attention,which is a weak and long-lasting emotion,receives less attraction.In this paper,we present a study of attention recognition based on electrocardiogram(ECG)signals,which contain a wealth of information related to emotions.Methods:The ECG dataset is derived from 10 subjects and specialized for attention detection.To relieve the impact of noise of baseline wondering and power-line interference,we apply wavelet threshold denoising as preprocessing and extract rich features by pan-tompkins and wavelet decomposition algorithms.To improve the generalized ability,we tested the performance of a variety of combinations of different feature selection algorithms and classifiers.Results:Experiments show that the combination of generic algorithm and random forest achieve the highest correct classification rate(CCR)of 86.3%.Conclusion:This study indicates the feasibility and bright future of ECG-based attention research. | Aihua Mao Zihui Du Dayu Lu Jie Luo | 2022 | Quantitative Biology2022，10，3： | 0 |
| 5 | Long-cycling lithium-oxygen batteries enabled by tailoring Li nucleation and deposition via lithiophilic oxygen vacancy in Vo-TiO_(2)/Ti_(3)C_(2)Tx composite anodes显示文摘Uncontrollable Li dendrite growth and infinite volume fluctuation during durative plating and stripping process gravely hinder the application of metallic Li electrode in lithium-oxygen batteries.Herein,oxygen vacancy-rich TiO_(2)(Vo-TiO_(2))nanoparticles(NPs)uniformly dispersing on Ti_(3)C_(2)T_(x)(Vo-TiO_(2)/Ti_(3)C_(2) T_(x))with excellent lithiophilicity feature are presented as effective composite anodes,on which a dense and uniform Li growth behavior is observed.Based on electrochemical studies,mutiphysics simulation and theoretical calculation,it is found that Vo-TiO_(2) coupling with three dimensional(3 D)conductive Ti_(3)C_(2) T_(x) MXene forms highly ordered lithiophilic sites which succeed in guiding Li ions flux and adsorption,thus modulating the uniform Li nucleation and growth.As a result,this composite electrode is capable of preserving Li with high areal capacity of~10 mAh cm^(-2) without the presence of dendrites and large volume expansion.Consequently,the as-prepared Vo-TiO_(2)/Ti_(3)C_(2) T_(x)@Li anode shows outstanding performance including low voltage hysteresis(~19 mV)and superior durability(over 750 h).When assembling with the Vo-TiO_(2)/Ti_(3)C_(2) T_(x)@Li anodes,lithium-oxygen batteries also deliver enhanced cycling stability and improved rate performance.This work demonstrates the effectiveness of oxygen vacancies in guiding Li nucleating and plating behavior at initial stage and brings a promising strategy for promoting the development of advanced Li metal-based batteries. | Yu Yan Chaozhu Shu Ruixin Zheng Minglu Li Zhiqun Ran Miao He Longfei Ren Dayue Du Ying Zeng | 2022 | Journal of Energy Chemistry2022，31，2： | 0 |
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