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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Comparison of the efficacy and safety of rosuvastatin versus atorvastatin , simvastatin , and pravastatin across doses (STELLAR * * STELLAR = Statin Therapies for Elevated Lipid Levels compared Across doses to Rosuvastatin. Trial)显示文摘 | Peter H Jones Michael H Davidson Evan A Stein Harold E Bays James M McKenney Elinor Miller Valerie A Cain James W Blasetto | 2003 | The American Journal of Cardiology2003，，2： | 2 |
| 3 | Agency Costs,Ownership Structure and Corporate Governance Mechanisms显示文摘 | Davidson W N | 2003 | Journal of Banking & Finance2003，27，： | 1 |
| 4 | RNA polymerase Ⅲ transcribes human microRNAs显示文摘 | Lanier W Davidson B L | 2006 | Nat Struct Mol Biol2006，13，12： | 1 |
| 5 | Improved Artificial Feeding System for Rearing the Whitefly Bemisia argentifolii ( Homoptera: Aleyrodidae ) 显示文摘 | DAVIDSON E W FAY M L BLACKMER J | 2000 | Florida Entomologist2000，83，4： | 1 |
| 6 | Taking industry seriously in information systems research 显示文摘 | CHIASSON M W DAVIDSON E | 2005 | MIS Quarterly2005，，： | 1 |
| 7 | A chirp scaling approach for processing squint mode SAR data 显示文摘 | Davidson G W Cumming I G Ito M R | 1996 | IEEE Trans on Aerospace and Electronic Systems1996，32，1： | 1 |
| 8 | Improvements to steady-state combustion modeling of Cyclotrimethylenetrinitramine显示文摘 | Davidson J E Beckstead M W | | 0，，03： | 1 |
| 9 | Agency Costs, Ownership Structure and Corporate Governance Mechanisms 显示文摘 | Singh M Davidson W N | 2003 | Journal of Banking & Finance2003，27，5： | 1 |
| 10 | A re-evaluation of the role of host defence peptides in mammalian immunity显示文摘 | Bowdish D M E Davidson D J Hancock R E W | 2005 | Current Protein and Peptide Science2005，6，1： | 1 |
| 11 | Skin Tears: Care and Management of the Older Aduh at Home显示文摘 | Holmes R F Davidson M W Thompson B J | 2013 | Home Healthc Nurse2013，31，2： | 1 |
| 12 | Advances in fluorescent protein technology显示文摘 | Shaner N C Patterson G H Davidson M W | 2007 | J Cell Sci2007，120，24： | 1 |
| 13 | Evidence of tick-borne organisms in mule deer (Odocoileus hemionus)from the westem United States 显示文摘 | Yabsley M J Davidson W R Stallknecht D E | 2005 | Vector Borne Zoonotic Dis2005，5，4： | 1 |
| 14 | Nutrient Ac- quisition and Population Growth of a Mixotrophic Alga in Axenic and Bacterized Cultures 显示文摘 | SANDERS R W CARON D A DAVIDSON J M | 2001 | Microbial Ecology2001，42，4： | 1 |
| 15 | Agency costs, owner- ship structure and corporate governance mechanisms 显示文摘 | Singh M Davidson Ⅲ W N | 2003 | Journal of Banking & Finance2003，27，5： | 1 |
| 16 | The BIOMASS mission : Mapping global forest biomass to better understand the terres- trial carbon cycle 显示文摘 | LE TOAN T QUEGAN S DAVIDSON M W J | 2011 | Remote Sensing of Environment2011，115，11： | 1 |
| 17 | A FRET-based indicator for imaging mitochondrial zinc ions 显示文摘 | SREENATH K ALLEN J R DAVIDSON M W | 2011 | Chemical Communications2011，47，11： | 1 |
| 18 | A Chirp Scaling Approach for Processing Squint Mode SAR Data显示文摘 | Davidson G W Cumming I G Ito M R | 1996 | IEEE Trans on AES1996，32，1： | 1 |
| 19 | Agency costs,ownership structure and corporate governance mechanisms显示文摘 | SINGH M DAVIDSON III W N | 2003 | Journal of Banking&Finance2003，27，5： | 1 |
| 20 | A Chirp Scaling Approach for Processing Squint Mode SAR Data显示文摘 | Davidson G W Cumming I G Ito M R | 1996 | IEEE Trans on AES1996，32，1： | 1 |
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