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您的检索式：作者名="David Z.Wang"
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| 1 | 中国非瓣膜性心房颤动患者华法林使用不足的相关因素分析显示文摘目的:评估中国首发缺血性卒中或短暂性脑缺血发作(TIA)的已知非瓣膜性心房颤动(NVAF)患者华法林的使用情况及使用不足的相关因素。方法:从中国国家卒中登记数据库(CNSR)中连续筛选首发缺血性卒中或TIA的NVAF患者,筛选已知心房颤动和新发心房颤动患者,评估华法林在适合抗凝治疗的已知心房颤动患者中的使用比例。采用多变量logistic回归模型评估华法林使用不足的相关因素。结果:在筛选出的11 080例首发缺血性卒中或TIA患者中,有996例(9.7%)患者存在NVAF且无抗凝治疗禁忌症,其中有592例既往已知存在心房颤动。在这些患者中,只有96例(16.2%)发病前服用了华法林,496例(83.8%)发病前未服用华法林。在服用华法林的患者中,只有1例患者入院时的国际标准化比值(INR)在治疗范围(2.0~3.0)内。依据CHADS2卒中风险评分,在卒中发生前的低危心房颤动患者中,有近20.2%的患者服用了华法林,而在中危及高危患者中,华法林的服用比例分别只有15.2%和16.4%。年老的和既往存在冠心病病史的患者服用华法林的可能性较小,而发病前服用抗血小板药物的患者更有可能服用华法林。结论:CNSR中首发缺血性卒中或TIA的NVAF患者中,适宜抗凝治疗的患者存在严重的华法林使用不足,即使接受抗凝治疗,达标率也极低。如果发病前给予合适的抗凝治疗并监测,许多由心房颤动导致的卒中和TIA就可避免。 | 王春娟 王春雪 王拥军 王伊龙 赵性泉 刘丽萍 David Z.Wang 李昊 杨中华 | 2012 | 中国新药杂志2012，21，11： | 10 |
| 2 | Metal chelation reduces skin epithelial inflammation and rescues epithelial cells from toxicity due to thermal injury in a rat model显示文摘Background:One of the most pervasive complications of burn injury is wound progression,characterized by continuous tissue destruction in untreated wounds,which leads to wound infection,inflammation,oxidative stress and excessive scar formation.We determined whether additional tissue destruction could be attenuated with Livionex formulation(LF)lotion,which contains a metal-chelating agent and reduces inflammation in burn wounds.Methods:We subjected male Sprague Dawley rats to a 2%total body surface area(TBSA)burn using a brass comb model and topically applied LF lotion(containing ethylenediaminetetraacetic acid and methyl sulfonyl methane)to the affected area every 8 hours over 3 days.Inflammatory cytokine levels,cell apoptosis and wound healing were compared in LF lotion-treated and untreated rats.Statistical analysis was performed using a one-way analysis of variance in conjunction with Tukey’s post-hoc test.Results:Serum inflammatory cytokines were not detectable after 3 days,suggesting that small burn wounds induce only an immediate,localized inflammatory response.Microscopy revealed that LF lotion improved burn site pathology.Deoxynucleotidyl transferase biotin-d-UTP nick-end labeling staining showed reduced cell death in the LF-treated samples.LF lotion prevented the spread of tissue damage,as seen by increased amounts of Ki-67-positive nuclei in the adjacent epidermis and hair follicles.Tumor necrosis factor-alpha,interleukin-6 and inducible nitric oxide synthase levels in LF-treated skin sections from burned rats were comparable to the levels observed in unburned control sections,indicating that LF lotion reduces inflammation in and around the burn site.Conclusions:These results establish LF lotion as a therapeutic agent for reducing inflammatory stress,cell death and tissue destruction when applied immediately after a burn injury.Further studies of LF lotion on large TBSA burns will determine its efficacy as an emergency treatment for reducing long-term morbidity and scarring. | Amina El Ayadi Cheng Z.Wang Min Zhang Michael Wetzel Anesh Prasai Celeste C.Finnerty Perenlei Enkhbaatar David N.Herndon Naseem H.Ansari | 2020 | Burns & Trauma2020，8，1： | 1 |
| 3 | 看美国卒中治疗改进措施,思考中国卒中医疗挑战显示文摘在美国,卒中医疗质量改进在所有的医疗卫生改进措施中起步最早。卒中是成人致残的第一大疾病,是成人死亡的第三大疾病,花费已超过5604L美元,常常是诊断相关组(diagnosisrelatedgrouD,DRG)入院的第5位原因。卒中医疗质量改进始于20世纪90年代末期。 | David Z.Wang | 2012 | 中国卒中杂志2012，7，8： | 0 |
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