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| 1 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 2 | Management of acute promyelocytic leukemia:recommendations from an expert panel on behalf of the European Leukemia Net显示文摘 | MIGUEL A S DAVID G MARTIN S T | 2009 | Blood2009，113，： | 1 |
| 3 | A framework to study neary optinud solutions of linear programming models developed for agricultural land sue exploration 显示文摘 | David M Eligius M T Martin K | 2000 | Ecological Modeling2000，，131： | 1 |
| 4 | Characterization of the tomato Cf-4 gene for resistance to Cladosporium fulvum identifies sequence that determine recognitional specificity in Cf-4 and Cf-9 显示文摘 | DAVID A J MARTIN P | 1997 | The Pant Cell1997，9，12： | 1 |
| 5 | Dose rate and static/dynamic bias effects on CCDs显示文摘 | MARTIN E DAVID J P NUNS T | 2011 | IEEE Transcations on Nuclear Science2011，58，3： | 1 |
| 6 | Chlorination of indicator bacteria and viruses in primary sewage effluent 显示文摘 | Julia A T Martin R A and David N L | 2003 | Appl Envi- ron Microbio12003，69，4： | 1 |
| 7 | Effects of lowering body temperature via hyperhydration,with and without glycerol ingestion and practical precooling on cycling time trial performance in hot and humid conditions显示文摘 | Megan LR Ross Nikki A Jeacocke Paul B Laursen David T Martin | 2012 | Journal of the International Society of Sports Nutrition2012，，9： | 1 |
| 8 | Chlorination of Indicator Bacteria and Viruses in Primary Sewage Effluent显示文摘 | JULIA A T MARTIN R A DAVID N L | 2003 | Applied and Environmental Microbiology2003，69，4： | 1 |
| 9 | 显示文摘 | Mitchell David T Lee Sang Bok Martin Charles R | 2002 | J Am Chem Soc2002，124，11： | 1 |
| 10 | New Measures of Job Control, Cognitive Demand, and Production Responsibility显示文摘 | Jackson P R Wall T D Martin R David K | 1993 | Journal of Applied Psychology1993，，78： | 1 |
| 11 | A nanostructured honeycomb carbon anode显示文摘 | Li Naichao David T Mitchell Charles R Martin | 2003 | J Electrochem Soc2003，150，7： | 1 |
| 12 | A framework tostudy nearly optimal solutions of Linear programmingmodels developed for agricultural land use exploration显示文摘 | David M Eligius M T Martin K | | 0，，： | 1 |
| 13 | Nonlinear cyclic behavior of hy- brid fibre concrete structural walls 显示文摘 | Alessandro D Davide B Martin T | 2008 | Engineering Structures2008，30，2： | 1 |
| 14 | Rapid thermal synthesis of GaN nanocrystals and nanodisks显示文摘 | Zdeněk Sofer David Sedmidubsky ?těpán Huber Petr ?imek Filip ?aněk Ond?ej Jankovsky Eva Gregorová Roman Fiala Stanislava Matějková Martin Mikulics | 2013 | Journal of Nanoparticle Research2013，，1： | 1 |
| 15 | A framework to study nearly optimal solutions of linear programming models developed for agricultural land use exploration显示文摘 | David M Eligius M T Martin K | 2000 | Ecological Modeling2000，，131： | 1 |
| 16 | Insulin glargine plus oral antidiabetic agents in comparison with biphasic insulin in type 2 diabetes: a UK cost comparison显示文摘 | David O Carl T Martin K | 2011 | The British Journal of Diabetes & Vascular Disease2011，11，： | 1 |
| 17 | A framework to study nearly optimal solutions of linear programming models developed for agricultural land use exploration显示文摘 | Eligius M T Martin K | 2000 | Ecological Modeling2000，，131： | 1 |
| 18 | A framework to studynearl optimal solutions of linear programming models developed for agricultural land use exploration 显示文摘 | David M Eligius M T Martin K | 2000 | Eco-logical Modeling2000，，131： | 1 |
| 19 | An unexplained 10–40° shift in the location of some diverse neutral atom data at 1 AU显示文摘 | Michael R Collier Thomas E Moore David Simpson Aaron Roberts Adam Szabo Stephen Fuselier Peter Wurz Martin A Lee Bruce T Tsurutani | 2004 | Advances in Space Research2004，，1： | 1 |
| 20 | X-ray focusing with efficient high-NA multilayer Laue lenses显示文摘Multilayer Laue lenses are volume diffraction elements for the efficient focusing of X-rays.With a new manufacturing technique that we introduced,it is possible to fabricate lenses of sufficiently high numerical aperture(NA)to achieve focal spot sizes below 10 nm.The alternating layers of the materials that form the lens must span a broad range of thicknesses on the nanometer scale to achieve the necessary range of X-ray deflection angles required to achieve a high NA.This poses a challenge to both the accuracy of the deposition process and the control of the materials properties,which often vary with layer thickness.We introduced a new pair of materials—tungsten carbide and silicon carbide—to prepare layered structures with smooth and sharp interfaces and with no material phase transitions that hampered the manufacture of previous lenses.Using a pair of multilayer Laue lenses(MLLs)fabricated from this system,we achieved a two-dimensional focus of 8.4×6.8 nm2 at a photon energy of 16.3 keV with high diffraction efficiency and demonstrated scanning-based imaging of samples with a resolution well below 10 nm.The high NA also allowed projection holographic imaging with strong phase contrast over a large range of magnifications.An error analysis indicates the possibility of achieving 1 nm focusing. | Saša Bajt Mauro Prasciolu Holger Fleckenstein Martin Domaracký Henry N Chapman Andrew J Morgan Oleksandr Yefanov Marc Messerschmidt Yang Du Kevin T Murray Valerio Mariani Manuela Kuhn Steven Aplin Kanupriya Pande Pablo Villanueva-Perez Karolina Stachnik Joe PJ Chen Andrzej Andrejczuk Alke Meents Anja Burkhardt David Pennicard Xiaojing Huang Hanfei Yan Evgeny Nazaretski Yong S Chu Christian E Hamm | 2017 | Light(Science & Applications)2017，6，1： | 0 |
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