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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Computed tomography scans of paranasal sinuses before functional endoscopic sinus surgery显示文摘This review aims to familiarize the radiologist with the common types of sinus surgery including their indications and techniques.We also illustrate how surgeons interpret 3D sinus anatomy when evaluating computed tomography(CT)studies.Preoperative evaluation by CT is mandatory for all patients undergoing functional endoscopic sinus surgery(FESS).In the past decade in particular,CT of the paranasal sinuses has become a roadmap for FESS.The radiologist's goal is to report on five key points:the extent of sinus opacification,opacification of sinus drainage pathways,anatomical variants,critical variants,and condition of surrounding soft tissues of the neck,brain and orbits.We present a systematic approach to the use of coronal,axial,and sagittal images in CT evaluation before FESS. | Emma C Cashman Peter J MacMahon David Smyth | 2011 | World Journal of Radiology2011，3，8： | 10 |
| 3 | Percutaneous transluminal angioplasty and stenting in patients with proximal vertebral artery stenosis显示文摘 | George A. Antoniou David Murray George S. Georgiadis Stavros A. Antoniou Andrew Schiro Ferdinand Serracino-Inglott J. Vincent Smyth | 2012 | Journal of Vascular Surgery2012，，4： | 2 |
| 4 | Targeted Therapy for Gastric Cancer显示文摘 | Elizabeth Smyth David Cunningham | 2012 | Current Treatment Options in Oncology2012，，3： | 1 |
| 5 | CRABS CLAW and SPATULA,two Arabidopsis genes that control carpel development in parallel with AGAMOUS显示文摘 | Alvarez John Smyth David R | 1999 | Development1999，26，： | 1 |
| 6 | Treatment Outcomes of Resected Esophageal Cancer显示文摘 | Wayne Hofstetter Stephen G. Swisher Arlene M. Correa Kenneth Hess Joe B. Putnam Jaffer A. Ajani Marcelo Dolormente Rhodette Francisco Ritsuko R. Komaki Axbal Lara Faye Martin David C. Rice Arcenio J. Sarabia W. Roy Smythe Ara A. Vaporciyan Garrett L. Wals | 2002 | Annals of Surgery2002，，3： | 1 |
| 7 | Exacerbation of Oxazolone Colitis by Infection with the Helminth Hymenolepis diminuta显示文摘 | Arthur Wang Maria Fernando Gabriella Leung Van Phan David Smyth Derek M. McKay | 2010 | The American Journal of Pathology2010，，6： | 1 |
| 8 | A prospective evaluation of the utility of 2‐deoxy‐2‐[<sup>18</sup>F]fluoro‐ D ‐glucose positron emission tomography and computed tomography in staging locally advanced gastric cancer显示文摘 | Elizabeth Smyth Heiko Sch?der Vivian E. Strong Marinela Capanu David P. Kelsen Daniel G. Coit Manish A. Shah | 2012 | Cancer2012，，22： | 1 |
| 9 | Parkinson Disease: Research Update and Clinical Management显示文摘 | Thomas Fritsch Kathleen A. Smyth Maggie S. Wallendal Trevor Hyde Gary Leo David S. Geldmacher | 2012 | Southern Medical Journal2012，，12： | 1 |
| 10 | Plasma N-Terminal Pro-Brain Natriuretic Peptide and Adrenomedullin: New Neurohormonal Predictors of Left Ventricular Function and Prognosis After Myocardial Infarction显示文摘 | A. Mark Richards M. Gary Nicholls Tim G. Yandle Chris Frampton Eric A. Espiner John G. Turner Rona C. Buttimore John G. Lainchbury John M. Elliott Hamid Ikram Ian G. Crozier David W. Smyth | 1998 | Circulation1998，，19： | 1 |
| 11 | A prospective evaluation of the utility of 2‐deoxy‐2‐[18F]fluoro‐ D ‐glucose positron emission tomography and computed tomography in staging locally advanced gastric cancer显示文摘 | Elizabeth Smyth Heiko Sch?der Vivian E. Strong Marinela Capanu David P. Kelsen Daniel G. Coit Manish A. Shah | 2012 | Cancer2012，，22： | 1 |
| 12 | Determination of proanthocyanidins and catechin in beer and barley by highperformance liquid chromatography with dualelectrode electrochemical detedtion 显示文摘 | David M I Mcmurrough Malcom R Smyth | 1994 | Analyst1994，119，50： | 1 |
| 13 | Principles of Data Mining显示文摘 | David Hand Heikki Mannila Padhraic Smyth | 2001 | The MIT Press@2001，，： | 1 |
| 14 | Utility of PET, CT, and EUS to Identify Pathologic Responders in Esophageal Cancer显示文摘 | Stephen G. Swisher Mary Maish Jeremy J. Erasmus Arlene M. Correa Jaffer A. Ajani Robert Bresalier Ritsuko Komaki Homer Macapinlac Reginald F. Munden Joe B. Putnam David Rice W.Roy Smythe Ara A. Vaporciyan Garrett L. Walsh Tsung T. Wu Jack A. Roth | 2004 | The Annals of Thoracic Surgery2004，，4： | 1 |
| 15 | Determination of proanthocyanidins and catechin in beer and barley by high-performance liquid chromatography with dual-electrode electrochemical detedtion 显示文摘 | David M I Mcmurrough Malcom R Smyth | 1994 | Analyst1994，119，50： | 1 |
| 16 | Dispersed repeats in plant genomes显示文摘 | David R. Smyth | 1991 | Chromosoma1991，，6： | 1 |
| 17 | Comparative Influence of Forest Management and Habitat Structural Factors on the Abundances of Hollow-Nesting Bird Species in Subtropical Australian Eucalypt Forest显示文摘 | ANITA SMYTH RALPH Mac NALLY DAVID LAMB | | 0，，： | 1 |
| 18 | Cardiac Autotransplantation for Primary Cardiac Tumors显示文摘 | Michael J. Reardon S. Chris Malaisrie Jon-Cecil Walkes Ara A. Vaporciyan David C. Rice W. Roy Smythe Clement A. DeFelice Zbigniew J. Wojciechowski | 2006 | The Annals of Thoracic Surgery2006，，2： | 1 |
| 19 | Phase I Trial of Combretastatin A4 Phosphate (CA4P) in Combination with Bevacizumab in Patients with Advanced Cancer显示文摘 | Paul Nathan Martin Zweifel Anwar R. Padhani Dow-Mu Koh Matthew Ng David J. Collins Adrian Harris Craig Carden Jon Smythe Nita Fisher N. Jane Taylor J. James Stirling Shiao-Ping Lu Martin O. Leach Gordon J.S. Rustin Ian Judson | 2012 | Clinical Cancer Research2012，，： | 1 |
| 20 | A prospective evaluation of the utility of 2‐deoxy‐2‐[<sup>18</sup>F]fluoro‐ D ‐glucose positron emission tomography and computed tomography in staging locally advanced gastric cancer显示文摘 | Elizabeth Smyth Heiko Sch?der Vivian E. Strong Marinela Capanu David P. Kelsen Daniel G. Coit Manish A. Shah | 2012 | Cancer2012，，22： | 1 |
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