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您的检索式：作者名="David P. Lane"
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| 1 | Anatomy of Mdm2 and Mdm4 in evolution显示文摘老鼠双分钟(Mdm ) 基因从古老的真核细胞的 placozoa Trichoplax adhaerens 跨越进化 timeframe,全部暗示一个重要、可能保存的细胞的角色人现代人的历史。到 DNA 损坏的 DNA 正直和反应的维护包含许多关键规章的小径,包括对瘤 suppressor 蛋白质 p53 的精确控制。在大多数脊椎动物,通过指向的 proteasomal 的 p53 的降级被 Mdm2 和 Mdm2 相关的蛋白质 Mdm4 的 heterodimers 首先调停(也作为 MdmX 知道) 。Mdm2 和 Mdm4 让 p53 有约束力的区域,酸的领域,锌手指,和 C 终端包围在整个进化被保存的领域。当无脊椎的种类的定序的染色体的分析识别了单个 Mdm 基因时,脊椎动物典型地有 Mdm2 和 Mdm4 基因,建议一个复制事件百万年以前发生在关于 550-440 的无颚的脊椎动物的出现以前。在在 T 的 Mdm 和 p53 之间的功能的关系。adhaerens,存在 10 亿年了的一个有机体,暗示这二蛋白质一起演变维持保存并且调整的功能。 | Ban Xiong Tan Hoe Peng Liew Joy S. Chua Farid J. Ghadessy Yaw Sing Tan David P. Lane Cynthia R. Coffill | 2017 | Journal of Molecular Cell Biology2017，9，1： | 3 |
| 2 | Expression of the bacteriophage T4 lysozyme gene in tall fescue confers resistance to gray leaf spot and brown patch diseases显示文摘 | Shujie Dong H. David Shew Lane P. Tredway Jianli Lu Elumalai Sivamani Eric S. Miller Rongda Qu | 2008 | Transgenic Research2008，，1： | 1 |
| 3 | Pancreatic Cancer Proteome: The Proteins That Underlie Invasion, Metastasis, and Immunologic Escape显示文摘 | Ru Chen Eugene C. Yi Samuel Donohoe Sheng Pan Jimmy Eng Kelly Cooke David A. Crispin Zhaoli Lane David R. Goodlett Mary P. Bronner Ruedi Aebersold Teresa A. Brentnall | 2005 | Gastroenterology2005，，4： | 1 |
| 4 | p53:updates on mechanisms,biology and therapy (Ⅱ)显示文摘In the second volume of this special issue, we focus on the activity and function of the mutant p53 proteins. The elegant work of Nakayama and Oshima (2019) uses mouse models of colorectal cancer to directly dem on strate the role that expression of the R273H protein has in promoting invasion. Using both animal studies and organotypic cultures, they are able to demonstrate that the gain-of-function (GOF) is driven by high-level nuclear expression of the protein and that this high-level expression requires escaping from Mdm2-depe ndent degradation and environ mental influe nee that are especially see n at the invadi ng front of the tumor. Their studies show that wildtype p53 can inhibit the GOF of the mutant protein providing clear support for the need for loss of the wild-type allele as the tumor progresses. This elegant in vivo work shows that the dominantnegative function of mutant p53 proteins has limited penetrance and helps to clarify this controversial area. | David P. Lane Chandra S. Verma | 2019 | Journal of Molecular Cell Biology2019，11，4： | 1 |
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