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| 1 | MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma显示文摘Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. | Cameron M Smith David I Watson Michael Z Michael Damian J Hussey | 2010 | World Journal of Gastroenterology2010，16，5： | 23 |
| 2 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 3 | Eutrophication: Nitrate flux in the Mississippi River显示文摘 | Mcisaa C G David M B Gertner G Z et ai | 2001 | Nature2001，414，： | 1 |
| 4 | Eutrophication:nitrate flux in the Mississippi River显示文摘 | MCISAAC G F DAVID M B GERTNER G Z | 2001 | Nature2001，414，： | 1 |
| 5 | Signal suppression/enhancement in high-perform ance liquid chromatography tandem mass spectrometry显示文摘 | FABIO G ELEONORA M DAVIDE Z | 2010 | J Chromatogr A2010，1217，： | 1 |
| 6 | The choice of irrigation technolo- gies in california 显示文摘 | CASWELL M DAVID Z | 1985 | American Journal of Agricultural E- conomics1985，67，2： | 1 |
| 7 | Eutrophication: nitrate flux in the Mississippi Pdver显示文摘 | McIsaac G F David M B Gertner G Z | 2001 | Nature2001，414，6860： | 1 |
| 8 | Increasing bur- den of methieillin-resistant Staphylococcus aureus hospitaliza- tions at US Academic Medical Centers, 2003-2008显示文摘 | David M Z Medvdev S Hohmann S F | 2012 | Infect Control Hosp Epidemiol2012，33，8： | 1 |
| 9 | Inhibitory effects of pyridoxal phosphate,ascorbate and aminoguanidine on nonenzymatic glycosylation显示文摘 | KHATAMI M SULDAN Z DAVID I | | 0，，21： | 1 |
| 10 | Bi-directional PCA with assembled matrix distance metric for image recognition 显示文摘 | ZUO W M DAVID Z WANG K Q | 2006 | IEEE Transaction Systems Man and Cybernetics2006，36，4： | 1 |
| 11 | Friction stir spot welding of advanced high strength steels: A feasibility study显示文摘 | Feng Z Santella M L David S A | 2005 | Society of Automotive Engineem2005，，114： | 1 |
| 12 | Range-wide population genetic analysis of the endangered northern riffleshell mussel,Epioblasma torulosa rangiana(Bivalvia:Unionoida)显示文摘 | David T Z Robert W M | 2007 | Conserv Genet2007，，8： | 1 |
| 13 | Reduction of U(VI) in goethite (a-FeOOH) suspensions by a dissimilatory metal-reducing bacterium显示文摘 | James K F John M Z David W K | 2000 | Geochimica Cosmochimica Acta2000，64，18： | 1 |
| 14 | The Determination of Electrochemical Reactivity and Sustainability on Individual Hyper-Stoichiometric UOz+ Grains by Raman Microspectroscopy and Scanning Electrochemical Microscopy显示文摘 | He H M Ding Z F David W | 2009 | Electrhemistry Communications2009，11，8： | 1 |
| 15 | Grape-like leiomyomas of the uterus显示文摘 | David M P Homonnai T Z Deligdish L Loewenthal M | 1975 | Int Surg1975，60，： | 1 |
| 16 | Synchrotron FTIR microspectroscopy of single natural silk fibers显示文摘 | Sheng J L Qi Z M David P | 2011 | Biomacromolecules2011，12，9： | 1 |
| 17 | Behaviour of coal mineral matter in sintering and slagging of ash during the gasification process显示文摘 | RATALE H M DAVID F COLIN R W PETRUS C P LI Z S | 2011 | Fuel Process Technol2011，92，： | 1 |
| 18 | Role of Hertwig's epithelial root sheath cells in tooth root development 显示文摘 | Zeichnev -David M Oishi K Su Z | 2003 | Dev Dyn2003，228，4： | 1 |
| 19 | Laparoscopic surgery for subfertility associated with en- dometriosis 显示文摘 | Tal Z Jacobson James M N Duf fy David Barlow | 2011 | Human Reproduction Update2011，17，2： | 1 |
| 20 | A general synthesis of unsymmetrical tetra substituted ureas 显示文摘 | Alan R K David P M Yang B Z | 1997 | Journal of Organic Chemistry1997，62，： | 1 |
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